TR201910410T4 - Endometriyal patolojilerde kök hücre terapisi. - Google Patents

Endometriyal patolojilerde kök hücre terapisi. Download PDF

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Publication number
TR201910410T4
TR201910410T4 TR2019/10410T TR201910410T TR201910410T4 TR 201910410 T4 TR201910410 T4 TR 201910410T4 TR 2019/10410 T TR2019/10410 T TR 2019/10410T TR 201910410 T TR201910410 T TR 201910410T TR 201910410 T4 TR201910410 T4 TR 201910410T4
Authority
TR
Turkey
Prior art keywords
endometrial
subject
bmdsc
autologous
stem cells
Prior art date
Application number
TR2019/10410T
Other languages
English (en)
Turkish (tr)
Inventor
SIMÓN Carlos
SANTAMARIA Javier
Pellicer Antonio
Cervello Irene
Original Assignee
Igenomix S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igenomix S L filed Critical Igenomix S L
Publication of TR201910410T4 publication Critical patent/TR201910410T4/tr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
TR2019/10410T 2014-06-17 2015-06-05 Endometriyal patolojilerde kök hücre terapisi. TR201910410T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462013121P 2014-06-17 2014-06-17

Publications (1)

Publication Number Publication Date
TR201910410T4 true TR201910410T4 (tr) 2019-08-21

Family

ID=54329860

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/10410T TR201910410T4 (tr) 2014-06-17 2015-06-05 Endometriyal patolojilerde kök hücre terapisi.

Country Status (22)

Country Link
US (1) US11129851B2 (https=)
EP (3) EP4012023B1 (https=)
JP (2) JP6920062B2 (https=)
CN (2) CN107073040A (https=)
AU (1) AU2015275798B2 (https=)
BR (1) BR112016029558A2 (https=)
CA (1) CA2952559C (https=)
CY (2) CY1122615T1 (https=)
DK (2) DK3569697T3 (https=)
ES (3) ES2983444T3 (https=)
HR (3) HRP20240798T1 (https=)
HU (3) HUE044823T2 (https=)
LT (2) LT3569697T (https=)
MX (1) MX377300B (https=)
PL (3) PL3569697T3 (https=)
PT (2) PT3569697T (https=)
RS (3) RS63093B1 (https=)
RU (1) RU2725006C2 (https=)
SI (2) SI3158057T1 (https=)
SM (3) SMT201900400T1 (https=)
TR (1) TR201910410T4 (https=)
WO (1) WO2015193737A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
EP3467124A1 (en) 2012-06-06 2019-04-10 Fundació Institut de Recerca Biomèdica IRB (Barcelona) Method for the diagnosis, prognosis and treatment of lung cancer metastasis
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
KR101872965B1 (ko) 2012-10-12 2018-06-29 인바이오모션 에스.엘. C―maf를 이용하는 전립선암 전이의 진단, 예후 및 치료 방법
CA2903306A1 (en) 2013-03-15 2014-09-18 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the diagnosis, prognosis and treatment of metastatic cancer
US11129851B2 (en) 2014-06-17 2021-09-28 Igenomix S.L. Stem cell therapy in endometrial pathologies
JP7637323B2 (ja) * 2016-06-23 2025-02-28 ティソン バイオテック,インコーポレイテッド 副甲状腺ホルモン1型受容体を発現する細胞およびその使用
RU2699029C1 (ru) * 2018-12-10 2019-09-03 Частное образовательное учреждение дополнительного профессионального образования "Академия медицинского образования имени Федора Ивановича Иноземцева" (ЧОУ ДПО "Академия медицинского образования им. Ф.И. Иноземцева") Способ использования мезенхимальных стволовых клеток для улучшения состояния рубца на матке
RU2741621C1 (ru) * 2020-09-25 2021-01-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Способ лечения внутриматочных синехий
WO2023003130A1 (ko) 2021-07-23 2023-01-26 차의과학대학교 산학협력단 분리된 미토콘드리아를 유효성분으로 포함하는 아셔만 증후군 예방 또는 치료용 약학 조성물

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE140868T1 (de) 1989-05-05 1996-08-15 North Sydney Area Health Serv Steigerung der fruchtbarkeit
US6979533B2 (en) 1992-06-12 2005-12-27 The Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation
CA2203718A1 (en) 1997-04-25 1998-10-25 University Of British Columbia Cadherin-11 as an indicator of viable pregnancy
IL127896A0 (en) 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
AU2001240096A1 (en) 2000-03-08 2001-09-17 Rebecca L. Dubowy Methods of diagnosing and monitoring endometrial glandular development
AU2001264900A1 (en) 2000-05-24 2001-12-03 Schering Aktiengesellschaft Pharmaceutical use of fibulin-1
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
AUPR673001A0 (en) 2001-07-31 2001-08-23 Prince Henry's Institute Of Medical Research Pregnancy-related enzyme activity
DE10139874A1 (de) 2001-08-10 2003-04-30 Schering Ag Humane Mater-Proteine
GB0201284D0 (en) 2002-01-21 2002-03-06 Isis Innovation Screening methods for contraceptive and fertility agents
US20030186300A1 (en) 2002-03-20 2003-10-02 Ali Akoum Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment of related conditions
EP1511863A4 (en) 2002-05-14 2006-12-27 Univ Leland Stanford Junior ENDOMETRIAL GENES FOR THE DETECTION OF ENDOMETRIAL DISORDERS
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
ES2273061T3 (es) 2002-08-02 2007-05-01 Schering Aktiengesellschaft Agentes moduladores de receptores de progesterona con actividad antigonadotropa elevada para el control de fertilidad femenina y para la terapia por reemplazo hormonal.
US20060292567A1 (en) 2002-12-21 2006-12-28 Universitat Leipzig Method and means for determining specific conditions or changes in the uterine epithelium and in the epithelium of other organs
US20060286555A1 (en) 2003-08-21 2006-12-21 Van Beuningen Marinus G J Microarray support for bioprobe synthesis
WO2005026324A2 (en) 2003-09-08 2005-03-24 The Board Of Regents Of The University Of Texas System Method and composition for enhancing in vitro embryo development by supplementing culture medium with prostaglandin or a prostaglandin analog
CN1863905A (zh) 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物
CA2550900A1 (en) 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
EP1765083A4 (en) 2004-05-28 2008-08-20 Serono Lab USE OF IL-17 TO TREAT FERTILITY DISORDERS
JP2009531705A (ja) * 2006-03-31 2009-09-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超短t2*緩和測定法を用いた細胞測定のためのシステムおよび方法
JP2007278750A (ja) 2006-04-04 2007-10-25 Ono Pharmaceut Co Ltd プロスタグランジン類及びその類縁体の定量方法
WO2008036374A2 (en) * 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
GB0703683D0 (en) * 2007-02-26 2007-04-04 Ark Therapeutics Ltd The treatment of complications in pregnancy
US9259233B2 (en) * 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
WO2009143633A1 (en) 2008-05-30 2009-12-03 Institut De Recherches Cliniques De Montreal Pcsk9 inhibitors and methods of use thereof
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
WO2013166281A1 (en) * 2012-05-02 2013-11-07 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
EP2348318A1 (en) 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
EP2768976B1 (en) 2011-10-21 2018-01-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for assessing endometrial receptivity of a patient after controlled ovarian hyperstimulation
US9423402B2 (en) 2011-11-30 2016-08-23 Singapore Health Services Pte. Ltd. GM1 ganglioside to annexin V microparticle polypeptide ratio for biological monitoring
MX356775B (es) 2012-06-27 2018-06-13 Hoffmann La Roche Medios y metodos que aplican sflt-1/plgf o relacion de endoglina/plgf para descartar el inicio de preeclampsia en un determinado periodo de tiempo.
RU2515475C1 (ru) 2012-11-15 2014-05-10 Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте
JP6684263B2 (ja) 2014-03-21 2020-04-22 アイジェノミクス エセ.エレ. 子癇前症の早期検出
US11129851B2 (en) 2014-06-17 2021-09-28 Igenomix S.L. Stem cell therapy in endometrial pathologies

Also Published As

Publication number Publication date
CN107073040A (zh) 2017-08-18
ES2736117T3 (es) 2019-12-26
AU2015275798A1 (en) 2017-02-02
US11129851B2 (en) 2021-09-28
SI3158057T1 (sl) 2019-10-30
HRP20220419T1 (hr) 2022-05-27
PT3158057T (pt) 2019-07-19
LT3158057T (lt) 2019-09-25
RS65719B1 (sr) 2024-08-30
HRP20240798T1 (hr) 2024-09-27
CY1125938T1 (el) 2024-02-16
PT3569697T (pt) 2022-05-02
EP3158057B1 (en) 2019-04-17
EP4012023B1 (en) 2024-05-15
CN116747241A (zh) 2023-09-15
EP3569697A1 (en) 2019-11-20
JP6920062B2 (ja) 2021-08-18
DK3158057T3 (da) 2019-07-29
BR112016029558A2 (pt) 2017-08-22
EP3158057A1 (en) 2017-04-26
WO2015193737A1 (en) 2015-12-23
JP2020138984A (ja) 2020-09-03
JP2017522288A (ja) 2017-08-10
RU2725006C2 (ru) 2020-06-29
HUE067463T2 (hu) 2024-10-28
CA2952559A1 (en) 2015-12-23
AU2015275798B2 (en) 2021-03-25
PL4012023T3 (pl) 2024-09-02
EP4012023C0 (en) 2024-05-15
CY1122615T1 (el) 2021-03-12
EP3569697B1 (en) 2022-01-05
EP4012023A1 (en) 2022-06-15
MX2016016756A (es) 2017-11-02
HUE044823T2 (hu) 2019-11-28
SI3569697T1 (sl) 2022-05-31
RS59210B1 (sr) 2019-10-31
RU2017101147A3 (https=) 2019-02-06
MX377300B (es) 2025-03-07
SMT202200155T1 (it) 2022-05-12
ES2983444T3 (es) 2024-10-23
ES2910306T3 (es) 2022-05-12
LT3569697T (lt) 2022-04-25
PL3569697T3 (pl) 2022-07-04
US20170128492A1 (en) 2017-05-11
EP3569697B8 (en) 2022-04-27
SMT202400270T1 (it) 2024-07-09
CA2952559C (en) 2023-01-24
RS63093B1 (sr) 2022-04-29
HRP20191240T1 (hr) 2019-11-01
DK3569697T3 (da) 2022-04-04
PL3158057T3 (pl) 2020-05-18
HUE058328T2 (hu) 2022-07-28
RU2017101147A (ru) 2018-07-17
SMT201900400T1 (it) 2019-09-09

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