TR201901472T4 - Kondroitin sülfat ve hiyalüronik asit türevlerini içeren farmasötik formülasyonlar. - Google Patents
Kondroitin sülfat ve hiyalüronik asit türevlerini içeren farmasötik formülasyonlar. Download PDFInfo
- Publication number
- TR201901472T4 TR201901472T4 TR2019/01472T TR201901472T TR201901472T4 TR 201901472 T4 TR201901472 T4 TR 201901472T4 TR 2019/01472 T TR2019/01472 T TR 2019/01472T TR 201901472 T TR201901472 T TR 201901472T TR 201901472 T4 TR201901472 T4 TR 201901472T4
- Authority
- TR
- Turkey
- Prior art keywords
- hyaluronic acid
- acid derivatives
- chondroitin sulfate
- pharmaceutical formulations
- formulations containing
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title abstract 2
- 229920001287 Chondroitin sulfate Polymers 0.000 title abstract 2
- 229940059329 chondroitin sulfate Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000000491 Tendinopathy Diseases 0.000 abstract 2
- 208000005615 Interstitial Cystitis Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000023835 Tendon disease Diseases 0.000 abstract 1
- 206010043255 Tendonitis Diseases 0.000 abstract 1
- 208000004760 Tenosynovitis Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 210000001179 synovial fluid Anatomy 0.000 abstract 1
- 201000004595 synovitis Diseases 0.000 abstract 1
- 201000004415 tendinitis Diseases 0.000 abstract 1
- 208000013515 tendinosis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mevcut buluş, osteoartrit, subkondral hasar, osteoporoz, sinovit, tenosinovitis, tendinit, tendinozisin tedavisinde ve bir eklem içi yıkama sıvısı olarak ve osteokondral ameliyatı takiben sinoviyal akışkanının bir viskoz ikamesi olarak kullanılacak olan spesifik yüksek molekül ağırlıklı hiyalüronik asit türevleri ve kondroitin sülfatın bir kombinasyonunu barındıran farmasötik formülasyonlar ile ilgilidir. Bu formülasyonlar aynı zamanda interstisyel sistitin tedavisine uygundur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000098A ITPD20120098A1 (it) | 2012-03-30 | 2012-03-30 | "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico" |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201901472T4 true TR201901472T4 (tr) | 2019-02-21 |
Family
ID=46000143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/01472T TR201901472T4 (tr) | 2012-03-30 | 2013-03-27 | Kondroitin sülfat ve hiyalüronik asit türevlerini içeren farmasötik formülasyonlar. |
Country Status (12)
Country | Link |
---|---|
US (2) | US9655918B2 (tr) |
EP (3) | EP3449927B1 (tr) |
CN (1) | CN104220078A (tr) |
CA (1) | CA2868078C (tr) |
EA (2) | EA029237B1 (tr) |
ES (2) | ES2887581T3 (tr) |
HR (1) | HRP20190131T1 (tr) |
IT (1) | ITPD20120098A1 (tr) |
PL (1) | PL2946782T3 (tr) |
SI (1) | SI2946782T1 (tr) |
TR (1) | TR201901472T4 (tr) |
WO (1) | WO2013144867A1 (tr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITPD20120098A1 (it) * | 2012-03-30 | 2013-10-01 | Fidia Farmaceutici | "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico" |
ITMI20132116A1 (it) | 2013-12-18 | 2015-06-19 | Apharm Srl | Associazione di glicosamminoglicani e ciclodestrine |
CN104940221A (zh) * | 2015-05-13 | 2015-09-30 | 北京大清生物技术有限公司 | 一种用于膀胱和尿道上皮损伤修复的组合物 |
EP3111941A1 (en) | 2015-06-30 | 2017-01-04 | Süleyman Patir | Compositions comprising chondroitin sulfate for prophylaxis or treatment of damaged articular cartilage |
EP3400950B1 (de) | 2017-05-12 | 2019-11-13 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (20 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
EP3400951B1 (de) * | 2017-05-12 | 2019-12-11 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
EP3691654A4 (en) | 2017-09-25 | 2021-11-24 | Surface Pharmaceuticals, Inc. | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF EYE SURFACE DISEASES |
MX2021008711A (es) | 2019-01-30 | 2021-08-19 | Bausch & Lomb | Red polimerica reticulada y uso de esta. |
IT201900024208A1 (it) * | 2019-12-17 | 2021-06-17 | Altergon Sa | Miscele iniettabili di acido ialuronico per uso in dermoestetica |
TR201922907A2 (tr) * | 2019-12-31 | 2021-07-26 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Osteoartri̇t tedavi̇si̇ i̇çi̇n yeni̇ bi̇r vi̇skoelasti̇k formülasyonu ve bunun üreti̇m yöntemi̇ |
CN111333879B (zh) * | 2020-04-16 | 2022-08-16 | 山东众山生物科技有限公司 | 一种交联透明质酸的硫酸软骨素类化合物及其应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1212892B (it) | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
EP0138572B1 (en) | 1983-10-11 | 1990-07-25 | FIDIA S.p.A. | Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
US6051560A (en) | 1986-06-26 | 2000-04-18 | Nestle S.A. | Chrondroitin sulfate/sodium hyaluronate composition |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
IT1263393B (it) | 1993-07-30 | 1996-08-05 | Fidia Advanced Biopolymers Srl | Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare |
ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
IT1291291B1 (it) * | 1997-04-30 | 1999-01-07 | Chemedica Sa | Uso di acido ialuronico e relativi sali per la preparazione di una soluzione acquosa utile come liquido di lavaggio intra-articolare |
US6872819B1 (en) * | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
DE10053053A1 (de) * | 2000-10-19 | 2002-05-16 | Knoell Hans Forschung Ev | Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden |
MXPA01011542A (es) * | 2001-11-13 | 2003-05-22 | Alcon Inc | Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel. |
GB0130603D0 (en) * | 2001-12-20 | 2002-02-06 | Renaissance Healthcare Europ L | Improvements in or relating to ophthalmic solutions |
NZ540045A (en) * | 2002-10-16 | 2008-04-30 | Frank D Marcum | Treatment for traumatic synovitis and damaged articular cartilage with chondroitin sulfate, N-acetyl D-glucosamine and hyaluronan |
US7504387B2 (en) * | 2002-10-16 | 2009-03-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis |
ITPD20050056A1 (it) * | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
ITMI20061030A1 (it) * | 2006-05-26 | 2007-11-27 | Altergon Sa | Nuova composizione comprendente glicosamminoglicani a viscosita' controllata e uso di tale composizione nella terapuia della cistite cronica |
ITPD20060219A1 (it) * | 2006-05-31 | 2007-12-01 | Fidia Farmaceutici | Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi |
CN100594029C (zh) * | 2006-07-24 | 2010-03-17 | 凌沛学 | 一种关节腔内注射用药物组合物 |
US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
IT1393945B1 (it) * | 2009-04-21 | 2012-05-17 | Fidia Farmaceutici | Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche |
IT1395392B1 (it) | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
FR2954165B1 (fr) * | 2009-12-18 | 2012-01-13 | Jean-Noel Thorel | Compositions injectables a usage intra-articulaire associant un agent de viscosupplementation et un milieu de croissance des fibroblastes |
ITPD20120098A1 (it) * | 2012-03-30 | 2013-10-01 | Fidia Farmaceutici | "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico" |
-
2012
- 2012-03-30 IT IT000098A patent/ITPD20120098A1/it unknown
-
2013
- 2013-03-27 ES ES18200663T patent/ES2887581T3/es active Active
- 2013-03-27 CN CN201380018447.5A patent/CN104220078A/zh active Pending
- 2013-03-27 EP EP18200663.5A patent/EP3449927B1/en active Active
- 2013-03-27 US US14/389,301 patent/US9655918B2/en active Active
- 2013-03-27 SI SI201331339T patent/SI2946782T1/sl unknown
- 2013-03-27 CA CA2868078A patent/CA2868078C/en active Active
- 2013-03-27 EP EP13722549.6A patent/EP2830636A1/en not_active Withdrawn
- 2013-03-27 PL PL15171519T patent/PL2946782T3/pl unknown
- 2013-03-27 WO PCT/IB2013/052443 patent/WO2013144867A1/en active Application Filing
- 2013-03-27 ES ES15171519T patent/ES2709799T3/es active Active
- 2013-03-27 EP EP15171519.0A patent/EP2946782B1/en active Active
- 2013-03-27 TR TR2019/01472T patent/TR201901472T4/tr unknown
- 2013-03-27 EA EA201401074A patent/EA029237B1/ru not_active IP Right Cessation
- 2013-03-27 EA EA201792023A patent/EA201792023A3/ru unknown
-
2017
- 2017-04-17 US US15/489,299 patent/US10821131B2/en active Active
-
2019
- 2019-01-21 HR HRP20190131TT patent/HRP20190131T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013144867A1 (en) | 2013-10-03 |
US20150072954A1 (en) | 2015-03-12 |
EP3449927A1 (en) | 2019-03-06 |
ES2887581T3 (es) | 2021-12-23 |
EP2946782A2 (en) | 2015-11-25 |
ITPD20120098A1 (it) | 2013-10-01 |
ES2709799T3 (es) | 2019-04-17 |
EA029237B1 (ru) | 2018-02-28 |
SI2946782T1 (sl) | 2019-03-29 |
HRP20190131T1 (hr) | 2019-03-22 |
US10821131B2 (en) | 2020-11-03 |
EP2946782A3 (en) | 2016-02-24 |
EA201792023A3 (ru) | 2018-04-30 |
EA201792023A2 (ru) | 2018-01-31 |
EP3449927B1 (en) | 2021-06-23 |
CA2868078C (en) | 2020-04-14 |
EP2830636A1 (en) | 2015-02-04 |
CN104220078A (zh) | 2014-12-17 |
US20170216344A1 (en) | 2017-08-03 |
EA201401074A1 (ru) | 2015-01-30 |
CA2868078A1 (en) | 2013-10-03 |
US9655918B2 (en) | 2017-05-23 |
EP2946782B1 (en) | 2018-11-07 |
PL2946782T3 (pl) | 2019-04-30 |
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