TR201900264T4 - İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. - Google Patents
İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. Download PDFInfo
- Publication number
- TR201900264T4 TR201900264T4 TR2019/00264T TR201900264T TR201900264T4 TR 201900264 T4 TR201900264 T4 TR 201900264T4 TR 2019/00264 T TR2019/00264 T TR 2019/00264T TR 201900264 T TR201900264 T TR 201900264T TR 201900264 T4 TR201900264 T4 TR 201900264T4
- Authority
- TR
- Turkey
- Prior art keywords
- rna
- polyethylene glycol
- liposome
- immunogen
- delivery
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 5
- 230000002163 immunogen Effects 0.000 title abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 4
- 239000002202 Polyethylene glycol Substances 0.000 abstract 3
- 239000000232 Lipid Bilayer Substances 0.000 abstract 2
- 230000003053 immunization Effects 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000003827 glycol group Chemical group 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529878P | 2011-08-31 | 2011-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201900264T4 true TR201900264T4 (tr) | 2019-02-21 |
Family
ID=47003206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/00264T TR201900264T4 (tr) | 2011-08-31 | 2012-08-31 | İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20140255472A1 (https=) |
| EP (2) | EP3508220A1 (https=) |
| JP (1) | JP2014525461A (https=) |
| CN (1) | CN103974719A (https=) |
| AU (1) | AU2012301715B2 (https=) |
| BR (1) | BR112014004607A2 (https=) |
| CA (1) | CA2846043A1 (https=) |
| CY (1) | CY1121122T1 (https=) |
| DK (1) | DK2750707T3 (https=) |
| ES (1) | ES2705498T3 (https=) |
| HR (1) | HRP20190032T1 (https=) |
| HU (1) | HUE041800T2 (https=) |
| LT (1) | LT2750707T (https=) |
| MX (1) | MX366055B (https=) |
| PL (1) | PL2750707T3 (https=) |
| PT (1) | PT2750707T (https=) |
| RU (1) | RU2628705C2 (https=) |
| SG (2) | SG11201400250UA (https=) |
| SI (1) | SI2750707T1 (https=) |
| TR (1) | TR201900264T4 (https=) |
| WO (1) | WO2013033563A1 (https=) |
Families Citing this family (174)
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| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| RS63817B1 (sr) | 2010-07-06 | 2023-01-31 | Glaxosmithkline Biologicals Sa | Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RS63890B1 (sr) | 2010-08-31 | 2023-02-28 | Glaxosmithkline Biologicals Sa | Mali lipozomi za isporuku rnk koja kodira imunogen |
| PT3970742T (pt) | 2010-08-31 | 2022-06-27 | Glaxosmithkline Biologicals Sa | Lipossomas peguilados para entrega de arn codificador de imunogénio |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
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| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
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- 2012-08-31 CA CA 2846043 patent/CA2846043A1/en active Pending
- 2012-08-31 US US14/240,020 patent/US20140255472A1/en not_active Abandoned
- 2012-08-31 SG SG11201400250UA patent/SG11201400250UA/en unknown
- 2012-08-31 CN CN201280052386.XA patent/CN103974719A/zh active Pending
- 2012-08-31 SG SG10201602456WA patent/SG10201602456WA/en unknown
- 2012-08-31 MX MX2014002203A patent/MX366055B/es active IP Right Grant
- 2012-08-31 EP EP12769787.8A patent/EP2750707B1/en not_active Revoked
- 2012-08-31 SI SI201231501T patent/SI2750707T1/sl unknown
- 2012-08-31 WO PCT/US2012/053391 patent/WO2013033563A1/en not_active Ceased
- 2012-08-31 BR BR112014004607A patent/BR112014004607A2/pt not_active Application Discontinuation
- 2012-08-31 PT PT12769787T patent/PT2750707T/pt unknown
- 2012-08-31 RU RU2014112220A patent/RU2628705C2/ru active
- 2012-08-31 JP JP2014528651A patent/JP2014525461A/ja active Pending
- 2012-08-31 ES ES12769787T patent/ES2705498T3/es active Active
- 2012-08-31 HU HUE12769787A patent/HUE041800T2/hu unknown
- 2012-08-31 PL PL12769787T patent/PL2750707T3/pl unknown
- 2012-08-31 TR TR2019/00264T patent/TR201900264T4/tr unknown
- 2012-08-31 LT LTEP12769787.8T patent/LT2750707T/lt unknown
- 2012-08-31 DK DK12769787.8T patent/DK2750707T3/en active
- 2012-08-31 AU AU2012301715A patent/AU2012301715B2/en not_active Ceased
-
2019
- 2019-01-15 CY CY191100050T patent/CY1121122T1/el unknown
- 2019-12-16 US US16/714,877 patent/US20200113830A1/en not_active Abandoned
-
2023
- 2023-02-27 US US18/114,434 patent/US20240016736A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20240016736A1 (en) | 2024-01-18 |
| EP3508220A1 (en) | 2019-07-10 |
| CA2846043A1 (en) | 2013-03-07 |
| EP2750707A1 (en) | 2014-07-09 |
| SG10201602456WA (en) | 2016-04-28 |
| DK2750707T3 (en) | 2019-02-11 |
| SG11201400250UA (en) | 2014-03-28 |
| EP2750707B1 (en) | 2018-10-24 |
| RU2014112220A (ru) | 2015-10-10 |
| LT2750707T (lt) | 2019-01-10 |
| SI2750707T1 (sl) | 2019-02-28 |
| MX366055B (es) | 2019-06-26 |
| AU2012301715A1 (en) | 2014-03-13 |
| JP2014525461A (ja) | 2014-09-29 |
| WO2013033563A1 (en) | 2013-03-07 |
| CY1121122T1 (el) | 2019-12-11 |
| US20140255472A1 (en) | 2014-09-11 |
| AU2012301715B2 (en) | 2017-08-24 |
| ES2705498T3 (es) | 2019-03-25 |
| PT2750707T (pt) | 2019-01-23 |
| RU2628705C2 (ru) | 2017-08-21 |
| US20200113830A1 (en) | 2020-04-16 |
| PL2750707T3 (pl) | 2019-05-31 |
| CN103974719A (zh) | 2014-08-06 |
| MX2014002203A (es) | 2014-05-30 |
| BR112014004607A2 (pt) | 2017-03-21 |
| HUE041800T2 (hu) | 2019-05-28 |
| HRP20190032T1 (hr) | 2019-02-22 |
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