TR201819447T4 - 18F-sakkarid-folatlar. - Google Patents

18F-sakkarid-folatlar. Download PDF

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Publication number
TR201819447T4
TR201819447T4 TR2018/19447T TR201819447T TR201819447T4 TR 201819447 T4 TR201819447 T4 TR 201819447T4 TR 2018/19447 T TR2018/19447 T TR 2018/19447T TR 201819447 T TR201819447 T TR 201819447T TR 201819447 T4 TR201819447 T4 TR 201819447T4
Authority
TR
Turkey
Prior art keywords
saccharide
folate
folates
prosthetic group
diseases
Prior art date
Application number
TR2018/19447T
Other languages
English (en)
Inventor
Schibli Roger
Moser Rudolf
Magdalena Müller Cristina
Mensah Ametamey Simon
Ramona Fischer Cindy
Groehn Viola
Original Assignee
Merck & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Cie filed Critical Merck & Cie
Publication of TR201819447T4 publication Critical patent/TR201819447T4/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)

Abstract

Bu buluş, 18F izotopunun bir prostetik grubu vasıtasıyla, daha spesifik olarak bir folatın veya onun bir türevinin glutamat kısmına kovalent şekilde bağlanan, tercihen piranosid veya furanosid esasında siklik monosakkarid veya oligosakkarid gibi bir sakkarid grubu içeren bir prostetik grubu vasıtasıyla bağlandığı yeni 18F-folat radyofarmasötiklerine, bunların hazırlanma yöntemine ve yanı sıra bunların kanser ile enflamatuvar ve otoimmün hastalıkların teşhisinde ve izlenmesinde ve bu hastalıkların tedavisinde kullanımına yöneliktir.
TR2018/19447T 2011-08-22 2012-08-21 18F-sakkarid-folatlar. TR201819447T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11178260 2011-08-22

Publications (1)

Publication Number Publication Date
TR201819447T4 true TR201819447T4 (tr) 2019-01-21

Family

ID=46704677

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/19447T TR201819447T4 (tr) 2011-08-22 2012-08-21 18F-sakkarid-folatlar.

Country Status (18)

Country Link
US (2) US10322195B2 (tr)
EP (1) EP2776382B1 (tr)
JP (1) JP6161209B2 (tr)
KR (1) KR101994327B1 (tr)
CN (1) CN103732563B (tr)
AU (2) AU2012298546A1 (tr)
CA (1) CA2839654C (tr)
DK (1) DK2776382T3 (tr)
EA (1) EA201400253A1 (tr)
ES (1) ES2703107T3 (tr)
HK (1) HK1194355A1 (tr)
IL (1) IL230760A (tr)
PL (1) PL2776382T3 (tr)
PT (1) PT2776382T (tr)
SG (2) SG2014001085A (tr)
TR (1) TR201819447T4 (tr)
WO (1) WO2013026842A1 (tr)
ZA (1) ZA201400175B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
TWI732825B (zh) * 2016-05-20 2021-07-11 日商王子控股股份有限公司 圖案形成用定向自組裝組成物、圖案形成用定向自組裝組成物用單體及圖案形成方法
CN109232690A (zh) * 2018-09-10 2019-01-18 南方医科大学南方医院 一种正电子显像剂标准品前体及其制备方法
EP3671511B1 (en) 2018-12-19 2022-07-06 Rohde & Schwarz GmbH & Co. KG Communication system and method
CN111748002B (zh) * 2019-03-14 2022-03-29 北京和益源生物技术有限公司 一种脱氧葡萄糖修饰的叶酸衍生物及其合成与应用
CN111714640B (zh) * 2019-03-14 2023-02-14 北京和益源生物技术有限公司 一种糖修饰的叶酸衍生物制备的纳米运载颗粒及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276280A (en) 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4628090A (en) 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
KR101048279B1 (ko) 2002-05-30 2011-07-13 더 스크립스 리서치 인스티튜트 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션
CA2592302C (en) 2004-12-23 2013-10-29 Purdue Research Foundation Positron emission tomography imaging method
KR20080000620A (ko) 2005-04-27 2008-01-02 지멘스 메디컬 솔루션즈 유에스에이, 인크. 분자 이미징 프로브를 합성하기 위한 클릭 화학 방법
EP1940841B9 (fr) * 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
EP2109466B1 (en) 2007-02-07 2014-11-12 Purdue Research Foundation Positron emission tomography imaging method
EA200901346A1 (ru) 2007-04-11 2010-04-30 Мерк Эпрова Аг F-меченые фолаты
CN102827166A (zh) * 2007-04-11 2012-12-19 默克和西伊公司 18f-标记的叶酸类
PL2146944T3 (pl) * 2007-04-11 2014-05-30 Merck & Cie Sposób otrzymywania folianów znakowanych fluorem-18
CN101809039B (zh) * 2007-09-28 2012-08-29 那诺蒂克株式会社 叶酸修饰的环糊精化合物、其制备方法、靶向性药物传递系统用的药物传递剂、药物组合物及造影剂
WO2010040854A1 (en) * 2008-10-10 2010-04-15 Merck Eprova Ag 18f-labelled folates as pet radiotracers
CN103732595B (zh) * 2011-08-17 2017-02-08 默克及其合伙人公司 叶酸的白蛋白‑结合实体缀合物

Also Published As

Publication number Publication date
CA2839654C (en) 2021-02-16
JP6161209B2 (ja) 2017-07-12
CN103732563B (zh) 2016-04-20
DK2776382T3 (en) 2019-01-14
PL2776382T3 (pl) 2019-05-31
IL230760A0 (en) 2014-03-31
JP2014531411A (ja) 2014-11-27
AU2017203512A1 (en) 2017-06-15
CA2839654A1 (en) 2013-02-28
US20190255200A1 (en) 2019-08-22
EP2776382B1 (en) 2018-09-19
IL230760A (en) 2017-08-31
PT2776382T (pt) 2018-12-24
AU2012298546A1 (en) 2014-02-20
US10973936B2 (en) 2021-04-13
CN103732563A (zh) 2014-04-16
US20140193337A1 (en) 2014-07-10
KR101994327B1 (ko) 2019-06-28
SG2014001085A (en) 2014-03-28
EP2776382A1 (en) 2014-09-17
KR20140054284A (ko) 2014-05-08
ZA201400175B (en) 2015-08-26
SG10201606981QA (en) 2016-10-28
WO2013026842A1 (en) 2013-02-28
US10322195B2 (en) 2019-06-18
EA201400253A1 (ru) 2014-08-29
AU2017203512B2 (en) 2019-02-28
ES2703107T3 (es) 2019-03-07
HK1194355A1 (zh) 2014-10-17

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