TR201616998A1 - Di̇meti̇l fumarat i̇çeren geci̇kti̇ri̇lmi̇ş salim sağlayan dozaj formlari - Google Patents
Di̇meti̇l fumarat i̇çeren geci̇kti̇ri̇lmi̇ş salim sağlayan dozaj formlari Download PDFInfo
- Publication number
- TR201616998A1 TR201616998A1 TR2016/16998A TR201616998A TR201616998A1 TR 201616998 A1 TR201616998 A1 TR 201616998A1 TR 2016/16998 A TR2016/16998 A TR 2016/16998A TR 201616998 A TR201616998 A TR 201616998A TR 201616998 A1 TR201616998 A1 TR 201616998A1
- Authority
- TR
- Turkey
- Prior art keywords
- pharmaceutical composition
- delayed release
- composition according
- release pharmaceutical
- weight
- Prior art date
Links
- 230000003111 delayed effect Effects 0.000 title claims abstract 16
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 title claims abstract 9
- 229960004419 dimethyl fumarate Drugs 0.000 title claims abstract 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 18
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims 12
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 10
- 239000008185 minitablet Substances 0.000 claims 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 6
- 239000000454 talc Substances 0.000 claims 6
- 229910052623 talc Inorganic materials 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
- 229960002622 triacetin Drugs 0.000 claims 5
- 238000009505 enteric coating Methods 0.000 claims 4
- 239000002702 enteric coating Substances 0.000 claims 4
- 239000007888 film coating Substances 0.000 claims 4
- 238000009501 film coating Methods 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 239000010410 layer Substances 0.000 claims 4
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 3
- 239000004408 titanium dioxide Substances 0.000 claims 3
- 239000001069 triethyl citrate Substances 0.000 claims 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 3
- 235000013769 triethyl citrate Nutrition 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- -1 glidants Substances 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 238000007873 sieving Methods 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229920001206 natural gum Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bu buluş, dimetil fumaratı ve en az bir farmasötik olarak kabul edilebilir eksipiyanı içeren geciktirilmiş salım sağlayan farmasötik bileşim ile ilgilidir.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/16998A TR201616998A1 (tr) | 2016-11-23 | 2016-11-23 | Di̇meti̇l fumarat i̇çeren geci̇kti̇ri̇lmi̇ş salim sağlayan dozaj formlari |
| EP19152301.8A EP3513811A1 (en) | 2016-11-23 | 2017-11-22 | Delayed release dosage forms comprising dimethyl fumarate |
| PCT/EP2017/080120 WO2018095996A1 (en) | 2016-11-23 | 2017-11-22 | Delayed release dosage forms comprising dimethyl fumarate |
| EP17203118.9A EP3326653A1 (en) | 2016-11-23 | 2017-11-22 | Delayed release dosage forms comprising dimethyl fumarate |
| EA201991265A EA201991265A1 (ru) | 2016-11-23 | 2017-11-22 | Лекарственные формы с отсроченным высвобождением, содержащие диметилфумарат |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/16998A TR201616998A1 (tr) | 2016-11-23 | 2016-11-23 | Di̇meti̇l fumarat i̇çeren geci̇kti̇ri̇lmi̇ş salim sağlayan dozaj formlari |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201616998A1 true TR201616998A1 (tr) | 2018-06-21 |
Family
ID=60450512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2016/16998A TR201616998A1 (tr) | 2016-11-23 | 2016-11-23 | Di̇meti̇l fumarat i̇çeren geci̇kti̇ri̇lmi̇ş salim sağlayan dozaj formlari |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP3326653A1 (tr) |
| EA (1) | EA201991265A1 (tr) |
| TR (1) | TR201616998A1 (tr) |
| WO (1) | WO2018095996A1 (tr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113004699A (zh) * | 2019-12-20 | 2021-06-22 | 洛阳尖端技术研究院 | 一种硅橡胶及其制品 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201818293A2 (tr) * | 2018-11-30 | 2020-06-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Di̇meti̇l fumarat i̇çeren geci̇kmeli̇ salim sağlayan kapsül |
| MX2023014395A (es) * | 2021-06-04 | 2023-12-15 | Zim Laboratories Ltd | Composiciones de liberacion retardada de dimetilfumarato. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| WO2013076216A1 (en) * | 2011-11-24 | 2013-05-30 | Synthon Bv | Controlled release particles comprising dimethyl fumarate |
| CN114146080A (zh) | 2012-02-07 | 2022-03-08 | 比奥根玛公司 | 含有富马酸二甲酯的药物组合物 |
| US9410659B2 (en) * | 2014-02-10 | 2016-08-09 | The Boeing Company | Automated mobile boom system for crawling robots |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| WO2016113754A2 (en) * | 2015-01-14 | 2016-07-21 | Leiutis Pharmaceuticals Pvt, Ltd. | Novel oral dosage forms of dimethyl fumarate |
| EP3270911A4 (en) * | 2015-03-17 | 2018-08-29 | Hetero Labs Limited | Pharmaceutical compositions of dimethyl fumarate |
| WO2017145036A1 (en) * | 2016-02-25 | 2017-08-31 | Aurobindo Pharma Ltd | Pharmaceutical compositions comprising dimethyl fumarate |
-
2016
- 2016-11-23 TR TR2016/16998A patent/TR201616998A1/tr unknown
-
2017
- 2017-11-22 WO PCT/EP2017/080120 patent/WO2018095996A1/en active Application Filing
- 2017-11-22 EP EP17203118.9A patent/EP3326653A1/en not_active Withdrawn
- 2017-11-22 EA EA201991265A patent/EA201991265A1/ru unknown
- 2017-11-22 EP EP19152301.8A patent/EP3513811A1/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113004699A (zh) * | 2019-12-20 | 2021-06-22 | 洛阳尖端技术研究院 | 一种硅橡胶及其制品 |
| CN113004699B (zh) * | 2019-12-20 | 2022-11-29 | 洛阳尖端技术研究院 | 一种硅橡胶及其制品 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3513811A1 (en) | 2019-07-24 |
| EP3326653A1 (en) | 2018-05-30 |
| WO2018095996A1 (en) | 2018-05-31 |
| EA201991265A1 (ru) | 2019-10-31 |
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