TR200705749T1 - İşlem. - Google Patents

İşlem.

Info

Publication number
TR200705749T1
TR200705749T1 TR2007/05749T TR200705749T TR200705749T1 TR 200705749 T1 TR200705749 T1 TR 200705749T1 TR 2007/05749 T TR2007/05749 T TR 2007/05749T TR 200705749 T TR200705749 T TR 200705749T TR 200705749 T1 TR200705749 T1 TR 200705749T1
Authority
TR
Turkey
Prior art keywords
pantoprazole sodium
sodium
present
pantoprazole
mercapto
Prior art date
Application number
TR2007/05749T
Other languages
English (en)
Inventor
Srinivas L.Pathi
Rajendra Kankan Narayanrao
Original Assignee
Cipla Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd. filed Critical Cipla Ltd.
Publication of TR200705749T1 publication Critical patent/TR200705749T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bu buluş yüksek verimle ve saflıkla pantoprazol sodyum elde etmek üzere 2-kloro metil-3,4-dimetoksi piridin hidroklorür ile 2-merkapto-5-diflorometoksi benzimidazolun bir organik çözücü madde içinde, bir faz transfer katalizörü mevcudiyetinde reaksiyona sokularak ve ayrıca sulu sodyum hipohalit çözeltisi ile muameleye tabi tutularak pantoprazol sodyumun sentezi için yeni bir tek kaplık işlem açıklar. Bu buluş ayrıca pantoprazol sodyumun pantoprazol sodyum seskihidrata ve yanı sıra pantoprazol sodyum monohidrata dönüşümü için bir işlem açıklar.
TR2007/05749T 2004-12-16 2005-12-15 İşlem. TR200705749T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1350MU2004 2004-12-16

Publications (1)

Publication Number Publication Date
TR200705749T1 true TR200705749T1 (tr) 2007-12-24

Family

ID=35912924

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2007/05749T TR200705749T1 (tr) 2004-12-16 2005-12-15 İşlem.

Country Status (10)

Country Link
US (1) US8691995B2 (tr)
JP (1) JP5355893B2 (tr)
KR (1) KR101370844B1 (tr)
AU (1) AU2005315390B2 (tr)
CA (1) CA2591405A1 (tr)
DE (1) DE112005003147T5 (tr)
GB (1) GB2436262B (tr)
TR (1) TR200705749T1 (tr)
WO (1) WO2006064249A2 (tr)
ZA (1) ZA200706613B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004111029A2 (en) 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
CN102796078B (zh) * 2012-08-24 2014-10-29 杭州澳亚生物技术有限公司 一种泮托拉唑化合物、制备方法及其药物制剂
CN103012373B (zh) * 2013-01-16 2014-11-05 湖北济生医药有限公司 一种泮托拉唑钠化合物及其药物组合物
CN103214459B (zh) * 2013-03-22 2014-11-12 海南中化联合制药工业股份有限公司 泮托拉唑钠结晶化合物，其药物组合物及其制备方法
CN106467514A (zh) * 2016-09-12 2017-03-01 杭州中美华东制药有限公司 一种制备高稳定性泮托拉唑钠水合物的方法
CN111057044A (zh) * 2019-12-19 2020-04-24 北京民康百草医药科技有限公司 一种泮托拉唑钠倍半水合物单一晶型的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
DE4018642C2 (de) 1990-06-11 1993-11-25 Byk Gulden Lomberg Chem Fab Neue Salzform des 5-Difluormethoxy-2-[(3,4-dimethoxy-2-pyridyl) methylsulfinyl]-1H-benzimitazol-Natriumsalzes
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
AU1538397A (en) 1996-02-06 1997-08-28 Pdi-Research Laboratories, Inc. Synthesis of omeprazole-type pyridine derivatives and intermediates thereof
SK283805B6 (sk) * 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
ES2166269B1 (es) * 1999-07-14 2003-04-01 Sint Quimica Sa Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.
ES2185459B1 (es) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
CN100347167C (zh) 2001-02-02 2007-11-07 特瓦制药工业有限公司 取代的2－(2－吡啶基甲基)亚磺酰基－1h－苯并咪唑化合物的生产方法
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US6933389B2 (en) * 2002-09-02 2005-08-23 Dr. Reddy's Laboratories Limited Process for preparation of crystalline form-1 of pantoprazole sodium sesquihydrate
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US7507829B2 (en) * 2002-12-19 2009-03-24 Teva Pharmaceuticals Industries, Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
DE602004020730D1 (de) * 2003-01-15 2009-06-04 Cipla Ltd Pharmazeutisches verfahren und damit hergestellte verbindungen
ITMI20031813A1 (it) * 2003-09-23 2005-03-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di pantoprazolo e suoi sali.

Also Published As

Publication number Publication date
WO2006064249A3 (en) 2006-10-05
JP2008524190A (ja) 2008-07-10
US8691995B2 (en) 2014-04-08
GB0713385D0 (en) 2007-08-22
GB2436262A (en) 2007-09-19
CA2591405A1 (en) 2006-06-22
US20100016605A1 (en) 2010-01-21
GB2436262B (en) 2010-01-20
JP5355893B2 (ja) 2013-11-27
KR101370844B1 (ko) 2014-03-07
AU2005315390B2 (en) 2011-10-27
AU2005315390A1 (en) 2006-06-22
KR20070107001A (ko) 2007-11-06
WO2006064249A2 (en) 2006-06-22
DE112005003147T5 (de) 2008-01-17
ZA200706613B (en) 2009-03-25

Similar Documents

Publication Publication Date Title
TR200705749T1 (tr) İşlem.
Zhang et al. Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction
EA201001394A1 (ru) Способ получения дабигатрана
NZ599684A (en) Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NO20083909L (no) Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere
Liang et al. Inverse-electron-demand [4+ 2] cycloaddition of photogenerated aza-ortho-quinone methides with 1, 3, 5-triazinanes: access to perfluoroalkylated tetrahydroquinazolines
JP2021063097A5 (tr)
NO20072872L (no) Kjemisk prosess
JP2018528182A5 (tr)
NO20075384L (no) Tiadiazolsubstituerte kumarinderivater og deres anvendelse som leukotrienbiosynteseinhibitorer.
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
Khalafy et al. A convenient and mild synthesis of new 2-aryl-3-hydroxy-6, 7-dihydro-1H-indol-4 (5H)-ones via a one-pot, three-component reaction in water
Chorell et al. Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity
PE20100155A1 (es) Derivados de urea heterociclicos y metodos de uso de los mismos-332
WO2006114676A3 (en) A process for the preparation of rupatadine
Shan et al. Expanding the structural diversity of diarylureas as multi-target tyrosine kinase inhibitors
Smith et al. 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety
MXPA05003695A (es) Nuevo proceso para la sintesis de compuestos de 1,3-dihidro-2h-3-benzazepin-2-ona, y aplicacion en la sintesis de ivabradina y sales de adicion de la misma con un acido farmaceuticamente aceptable.
Jia et al. Radical cation salt induced tandem cyclization between anilines and N-vinyl amides: synthesis of 2-methyl-4-anilino-1, 2, 3, 4-tetrahydroquinoline derivatives
CN103193702B (zh) 含氮杂环化合物官能团化的方法
Kumar et al. A facile synthesis of naturally occurring 5-(3-indolyl) oxazoles
AU2013261735B2 (en) Methanethione compounds having antiviral activity
Wang et al. Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors
Cikotiene et al. The first example of the Fischer–Hepp type rearrangement in pyrimidines
DK1222160T3 (da) Fremgangsmåde til fremstilling af substituerede allylaminderivater og salte deraf