TR200101250A2 - 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses - Google Patents

4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Info

Publication number
TR200101250A2
TR200101250A2 TR2001/01250A TR200101250A TR200101250A2 TR 200101250 A2 TR200101250 A2 TR 200101250A2 TR 2001/01250 A TR2001/01250 A TR 2001/01250A TR 200101250 A TR200101250 A TR 200101250A TR 200101250 A2 TR200101250 A2 TR 200101250A2
Authority
TR
Turkey
Prior art keywords
hydroxybutylidene
salts
amino
preparation
acid
Prior art date
Application number
TR2001/01250A
Other languages
English (en)
Turkish (tr)
Inventor
Dabak Kad�R
A. �Zarslan Evren
�Ahbaz F�L�Z
Aslan Tuncer
Original Assignee
E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. filed Critical E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.
Priority to TR2001/01250A priority Critical patent/TR200101250A2/xx
Priority to PCT/TR2002/000018 priority patent/WO2002090367A1/en
Priority to US10/473,600 priority patent/US7009071B2/en
Priority to CA002445428A priority patent/CA2445428C/en
Priority to DE60208018T priority patent/DE60208018T2/de
Priority to AT02736468T priority patent/ATE312836T1/de
Priority to ES02736468T priority patent/ES2254691T3/es
Priority to JP2002587445A priority patent/JP3911287B2/ja
Priority to EP02736468A priority patent/EP1390373B9/en
Publication of TR200101250A2 publication Critical patent/TR200101250A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
TR2001/01250A 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses TR200101250A2 (tr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
PCT/TR2002/000018 WO2002090367A1 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
US10/473,600 US7009071B2 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
CA002445428A CA2445428C (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
DE60208018T DE60208018T2 (de) 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure
AT02736468T ATE312836T1 (de) 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure
ES02736468T ES2254691T3 (es) 2001-05-10 2002-05-08 Procedimiento para la preparacion de acido 4-amino-1-hidroxibutilideno-1,1-biofosfonico.
JP2002587445A JP3911287B2 (ja) 2001-05-10 2002-05-08 ４−アミノ−１−ヒドロキシブチリデン−１，１−ビホスホン酸（４−Ａｍｉｎｏ−１−ｈｙｄｒｏｘｂｕｔｙｌｉｄｅｎ−１，１−ｂｉｐｈｏｓｐｈｏｎｉｃａｃｉｄ）の調整方法
EP02736468A EP1390373B9 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Publications (1)

Publication Number Publication Date
TR200101250A2 true TR200101250A2 (tr) 2003-04-21

Family

ID=21623110

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Country Status (9)

Country Link
US (1) US7009071B2 (https=)
EP (1) EP1390373B9 (https=)
JP (1) JP3911287B2 (https=)
AT (1) ATE312836T1 (https=)
CA (1) CA2445428C (https=)
DE (1) DE60208018T2 (https=)
ES (1) ES2254691T3 (https=)
TR (1) TR200101250A2 (https=)
WO (1) WO2002090367A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
KR100897837B1 (ko) * 2001-12-24 2009-05-15 테바 파마슈티컬 인더스트리즈 리미티드 분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
KR100681282B1 (ko) 2002-05-17 2007-02-12 테바 파마슈티컬 인더스트리즈 리미티드 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
JP4642762B2 (ja) 2003-08-21 2011-03-02 サン・ファーマシューティカル・インダストリーズ・リミテッド ビスホスホン酸化合物の製造方法
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
EP1798236A1 (en) * 2005-12-13 2007-06-20 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof
ES2323728T3 (es) 2005-12-27 2009-07-23 Ipca Laboratories Limited Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2642321A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
US20090137808A1 (en) * 2006-03-21 2009-05-28 Albemarle Corporation Process for manufacturing bisphosphonic acids
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
US8026388B2 (en) 2008-07-11 2011-09-27 Synthon Bv Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
TW198039B (https=) * 1988-11-28 1993-01-11 Ciba Geigy Ag
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
EP1169326B1 (en) * 1999-02-17 2004-07-14 Teva Pharmaceutical Industries Ltd. Process for preparing alendronic acid

Also Published As

Publication number Publication date
JP3911287B2 (ja) 2007-05-09
ES2254691T3 (es) 2006-06-16
CA2445428A1 (en) 2002-11-14
DE60208018D1 (de) 2006-01-19
US20040152916A1 (en) 2004-08-05
US7009071B2 (en) 2006-03-07
DE60208018T2 (de) 2006-07-13
CA2445428C (en) 2006-05-02
JP2004528382A (ja) 2004-09-16
EP1390373B9 (en) 2006-08-16
EP1390373A1 (en) 2004-02-25
ATE312836T1 (de) 2005-12-15
EP1390373B1 (en) 2005-12-14
WO2002090367A1 (en) 2002-11-14

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