TR200101156T2 - Küçük parçacık boyuna sahip izotretinoin elde etmek için işlem ve izotretinoin bileşimleri. - Google Patents

Küçük parçacık boyuna sahip izotretinoin elde etmek için işlem ve izotretinoin bileşimleri.

Info

Publication number
TR200101156T2
TR200101156T2 TR2001/01156T TR200101156T TR200101156T2 TR 200101156 T2 TR200101156 T2 TR 200101156T2 TR 2001/01156 T TR2001/01156 T TR 2001/01156T TR 200101156 T TR200101156 T TR 200101156T TR 200101156 T2 TR200101156 T2 TR 200101156T2
Authority
TR
Turkey
Prior art keywords
isotretinoin
compositions
particle size
small particle
compounds
Prior art date
Application number
TR2001/01156T
Other languages
English (en)
Inventor
Ahmed Hashim
Martin Infeld Howard
Navnit Shah Hargovindas
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101156T2 publication Critical patent/TR200101156T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Mikronize izotretinoin bilesimleri elde etmek için bir islem anlatilmaktadir. Bu islem izotretinoin yagli bir vasita içinde süspansiyon halindeyken mikronize edilerek gerçeklestirilir. Mikronize izotretinoin bilesikleri ile bilesikleri içeren birim doz formlari da anlatilmaktadir. Bu bilesimlerden bazilari besin etkisi açisindan bilinen bilesimlerden üstündür.
TR2001/01156T 1998-10-30 1999-10-29 Küçük parçacık boyuna sahip izotretinoin elde etmek için işlem ve izotretinoin bileşimleri. TR200101156T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10633198P 1998-10-30 1998-10-30

Publications (1)

Publication Number Publication Date
TR200101156T2 true TR200101156T2 (tr) 2001-08-21

Family

ID=22310843

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01156T TR200101156T2 (tr) 1998-10-30 1999-10-29 Küçük parçacık boyuna sahip izotretinoin elde etmek için işlem ve izotretinoin bileşimleri.

Country Status (13)

Country Link
EP (1) EP1131068A1 (tr)
JP (1) JP2002528492A (tr)
KR (1) KR20010073226A (tr)
CN (1) CN1324235A (tr)
AR (1) AR020999A1 (tr)
AU (1) AU1044400A (tr)
BR (1) BR9914932A (tr)
CA (1) CA2347098A1 (tr)
NO (1) NO20012014L (tr)
PE (1) PE20001227A1 (tr)
TR (1) TR200101156T2 (tr)
WO (1) WO2000025772A1 (tr)
ZA (1) ZA200102731B (tr)

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US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
DE19932157A1 (de) * 1999-07-13 2001-01-18 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln
FR2807662A1 (fr) * 2000-04-12 2001-10-19 Cll Pharma Procede pour stabiliser la granulometrie d'un principe actif verulent disperse dans un liquide et ses applications
IN192188B (tr) * 2000-06-16 2004-03-13 Ranbaxy Lab Ltd
DE60104206T2 (de) 2000-09-22 2005-09-22 Galephar M/F Halbfeste arzneizubereitung enthaltend isotretinoin
EP1455730A4 (en) * 2001-12-06 2006-01-18 Ranbaxy Lab Ltd NANOTEHOUS ISOTRETINOINE COMPOSITIONS
EP1527774A1 (en) * 2003-11-03 2005-05-04 Basilea Pharmaceutica AG New formulation for retinoid-containing soft gelatin capsules
SE0303135D0 (sv) * 2003-11-25 2003-11-25 Lipocore Holding Ab Controlled food effect composition
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
AU2008215659B2 (en) * 2007-02-16 2012-11-01 Aska Pharmaceutical Co., Ltd. Pharmaceutical composition comprising microparticle oily suspension
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2010109259A1 (es) * 2009-03-26 2010-09-30 Grufarcol Ltda Métoda para preparar formulaciones de gel blando de isotretinoína líquida y la formulaciones obtenidas
US10022348B2 (en) 2009-05-20 2018-07-17 Sun Pharmaceutical Industries Limited Topical solution of isotretinoin
SG2014011969A (en) 2009-05-20 2014-09-26 Ranbaxy Lab Ltd Liquid dosage forms of isotretinoin
SG2014012173A (en) 2009-05-20 2014-07-30 Ranbaxy Lab Ltd Topical retinoid solutions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9078925B2 (en) 2012-06-18 2015-07-14 Galephar Pharmaceutical Research, Inc. Pharmaceutical semi-solid composition of isotretinoin
JP6018845B2 (ja) * 2012-09-03 2016-11-02 三生医薬株式会社 超微粉末含有カプセル剤の製造方法
WO2015181802A2 (en) * 2014-05-29 2015-12-03 Sun Pharmaceutical Industries Limited Oral pharmaceutical composition of isotretinoin
RU2016150868A (ru) * 2014-06-02 2018-07-17 Сан Фармасьютикал Индастриз Лимитед Пероральная фармацевтическая композиция изотретиноина
RU2017106013A (ru) * 2014-07-31 2018-08-28 Сан Фармасьютикал Индастриз Лимитед Фармацевтическая композиция изотретиноина для перорального приема
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
US9750711B2 (en) * 2014-10-01 2017-09-05 Sun Pharmaceutical Industries Limited Low dose oral pharmaceutical composition of isotretinoin
MA40781A (fr) * 2014-10-01 2017-08-08 Sun Pharmaceutical Ind Ltd Composition pharmaceutique d'isotrétinoïne à faible dosage destinée à la voie orale
JP2018520114A (ja) * 2015-05-25 2018-07-26 サン ファーマシューティカル インダストリーズ リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． イソトレチノインの１日１回経口医薬組成物
US10517846B2 (en) 2016-05-26 2019-12-31 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions for treating acne
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
WO2024006748A1 (en) 2022-07-01 2024-01-04 Acrotech Biopharma Inc. Pharmaceutical compositions comprising isotretinoin and processes for preparation and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557615C2 (de) * 1975-12-20 1985-08-14 Bayer Ag, 5090 Leverkusen Neue Niclosamid-Suspensionsformulierungen
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
CA1282326C (en) * 1984-12-14 1991-04-02 Paul J. Jarosz Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient

Also Published As

Publication number Publication date
ZA200102731B (en) 2002-07-03
WO2000025772A1 (en) 2000-05-11
AR020999A1 (es) 2002-06-05
CA2347098A1 (en) 2000-05-11
NO20012014D0 (no) 2001-04-24
CN1324235A (zh) 2001-11-28
KR20010073226A (ko) 2001-07-31
EP1131068A1 (en) 2001-09-12
NO20012014L (no) 2001-04-24
BR9914932A (pt) 2001-07-10
JP2002528492A (ja) 2002-09-03
PE20001227A1 (es) 2000-11-06
AU1044400A (en) 2000-05-22

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