TR200003199T2 - Karbapenem türevleri, bunların kullanımı ve ara birleşiği - Google Patents

Karbapenem türevleri, bunların kullanımı ve ara birleşiği

Info

Publication number
TR200003199T2
TR200003199T2 TR2000/03199T TR200003199T TR200003199T2 TR 200003199 T2 TR200003199 T2 TR 200003199T2 TR 2000/03199 T TR2000/03199 T TR 2000/03199T TR 200003199 T TR200003199 T TR 200003199T TR 200003199 T2 TR200003199 T2 TR 200003199T2
Authority
TR
Turkey
Prior art keywords
carbapenem
intermediate compound
combination
infectious diseases
carbapenem derivatives
Prior art date
Application number
TR2000/03199T
Other languages
English (en)
Inventor
Matsui Hiroshi
Takashima Hajime
Original Assignee
Kyoto Pharmaceutical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10122499A external-priority patent/JP2000344772A/ja
Priority claimed from JP10203730A external-priority patent/JP2000344773A/ja
Application filed by Kyoto Pharmaceutical Industries, Ltd. filed Critical Kyoto Pharmaceutical Industries, Ltd.
Publication of TR200003199T2 publication Critical patent/TR200003199T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Formül (I)'in bir karbapenem birlesigidir, ki burada R1 canli vücut içinde hidrolize edilebilir bir modifiye edici olmaktadir, R2 ve R3 ayni veya farklidir ve her biri asagi alkil olmaktadir, formül (I) ve R, tarifnamede tanimlandigi gibidir. Bulusun karbapenem birlesigi (I) oral kullanim ile sindirim yollarinda üstün olarak sogurulmaktadir ve genis bir araliktaki bakteri türlerine karsi yeterli antibakteriyel özellik göstermektedir. Dolayisiyla birlesik, korunma ve bulasici hastaliklarin tedavisi için (özel olarak bakteriyel bulasici hastaliklar)asiri biçimde kullanisli olmaktadir.
TR2000/03199T 1998-05-01 1999-04-28 Karbapenem türevleri, bunların kullanımı ve ara birleşiği TR200003199T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10122499A JP2000344772A (ja) 1998-05-01 1998-05-01 カルバペネム誘導体、その用途およびその中間体化合物
JP10203730A JP2000344773A (ja) 1998-07-17 1998-07-17 カルバペネム誘導体、およびその用途並びにその中間体化合物

Publications (1)

Publication Number Publication Date
TR200003199T2 true TR200003199T2 (tr) 2001-03-21

Family

ID=26459604

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03199T TR200003199T2 (tr) 1998-05-01 1999-04-28 Karbapenem türevleri, bunların kullanımı ve ara birleşiği

Country Status (24)

Country Link
US (1) US6410525B1 (tr)
EP (1) EP1078927B1 (tr)
KR (1) KR100589030B1 (tr)
CN (1) CN1163494C (tr)
AR (1) AR018335A1 (tr)
AT (1) ATE337321T1 (tr)
AU (1) AU760386B2 (tr)
BG (1) BG105004A (tr)
BR (1) BR9910098A (tr)
CA (1) CA2330641A1 (tr)
CO (1) CO5011051A1 (tr)
CZ (1) CZ292623B6 (tr)
DE (1) DE69932927D1 (tr)
HU (1) HUP0101735A3 (tr)
ID (1) ID27081A (tr)
NO (1) NO20005480L (tr)
NZ (1) NZ508493A (tr)
PL (1) PL343728A1 (tr)
RU (1) RU2222540C2 (tr)
SK (1) SK16382000A3 (tr)
TR (1) TR200003199T2 (tr)
TW (1) TW528750B (tr)
WO (1) WO1999057121A1 (tr)
YU (1) YU66700A (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620433A (zh) * 2000-07-19 2005-05-25 霍夫曼-拉罗奇有限公司 作为内皮肽转化酶抑制剂的吡咯烷衍生物
NZ530170A (en) * 2001-05-21 2005-09-30 Kyoto Pharma Ind Carbapenem compound
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JP4377231B2 (ja) 2001-11-05 2009-12-02 大日本住友製薬株式会社 新規なカルバペネム化合物
EP1612211A4 (en) 2003-04-08 2008-07-02 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUNDS
EP1785426A4 (en) * 2004-09-03 2008-02-20 Dainippon Sumitomo Pharma Co NEW CARBAPENEM DERIVATIVE
EP1864985A4 (en) * 2005-03-25 2010-01-06 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUND
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
CN101376656A (zh) * 2007-08-30 2009-03-04 山东轩竹医药科技有限公司 培南衍生物
BR112015023621A8 (pt) 2013-03-15 2018-01-23 Kala Pharmaceuticals Inc derivados de meropenem e suas utilizações
JP7437847B2 (ja) * 2018-10-01 2024-02-26 アリクサ ファーマシューティカルズ、インコーポレイテッド レレバクタムの誘導体およびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
JPS61275279A (ja) 1984-12-25 1986-12-05 Sankyo Co Ltd カルバペネム化合物
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
EP0597821A1 (en) 1988-04-01 1994-05-18 Sankyo Company Limited 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
US5242914A (en) 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
AU644008B2 (en) 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
US5712267A (en) 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
ATE223411T1 (de) 1995-12-21 2002-09-15 Sankyo Co 1-methylcarbapenem-derivate

Also Published As

Publication number Publication date
HUP0101735A2 (hu) 2001-12-28
ATE337321T1 (de) 2006-09-15
BG105004A (en) 2001-08-31
WO1999057121A1 (fr) 1999-11-11
CA2330641A1 (en) 1999-11-11
HUP0101735A3 (en) 2002-02-28
CN1307578A (zh) 2001-08-08
SK16382000A3 (sk) 2001-05-10
EP1078927B1 (en) 2006-08-23
AR018335A1 (es) 2001-11-14
EP1078927A1 (en) 2001-02-28
CO5011051A1 (es) 2001-02-28
PL343728A1 (en) 2001-09-10
NO20005480D0 (no) 2000-10-31
US6410525B1 (en) 2002-06-25
KR100589030B1 (ko) 2006-06-13
EP1078927A4 (en) 2003-01-08
TW528750B (en) 2003-04-21
RU2222540C2 (ru) 2004-01-27
CZ20003954A3 (cs) 2001-04-11
KR20010043196A (ko) 2001-05-25
YU66700A (sh) 2003-01-31
CN1163494C (zh) 2004-08-25
ID27081A (id) 2001-02-22
NO20005480L (no) 2000-12-20
BR9910098A (pt) 2000-12-26
AU760386B2 (en) 2003-05-15
CZ292623B6 (cs) 2003-11-12
NZ508493A (en) 2002-06-28
AU3627299A (en) 1999-11-23
DE69932927D1 (de) 2006-10-05

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