TR199902775T2 - 20(S)-Kamptotesin glikokonjugeleri. - Google Patents
20(S)-Kamptotesin glikokonjugeleri.Info
- Publication number
- TR199902775T2 TR199902775T2 TR1999/02775T TR9902775T TR199902775T2 TR 199902775 T2 TR199902775 T2 TR 199902775T2 TR 1999/02775 T TR1999/02775 T TR 1999/02775T TR 9902775 T TR9902775 T TR 9902775T TR 199902775 T2 TR199902775 T2 TR 199902775T2
- Authority
- TR
- Turkey
- Prior art keywords
- camptothecin
- glycoconjugeleri
- glucoconjugate
- oncosis
- hydroxylated
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000021603 oncosis Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Electrically Operated Instructional Devices (AREA)
Abstract
Söz konusu bulus 20(S)-kamptotesin glikokonjugeleri ile ilgilidir. Burada 3-0-metilli -L-fukoz birimlerinin 20 hidroksilli kamptotesin türevine tiyoüresi degistirilmis peptit ara halkasi yoluyla baglanan glikokonjuge bilesimlerinin bulusa ait olan yöntem ile hazirlanmalari ve bu bilesimlerinde tedaviye yönelik ilaç olarak bilhassa da onkozlarla baglantili olarak kullanimlari incelenmistir.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19720043 | 1997-05-14 | ||
DE19737477 | 1997-08-28 | ||
DE19801037A DE19801037A1 (de) | 1997-05-14 | 1998-01-14 | Glycokonjugate von 20(S)-Camptothecin |
DE1998113137 DE19813137A1 (de) | 1998-03-25 | 1998-03-25 | Glycokonjugate von 20(S)-Camptothecin |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199902775T2 true TR199902775T2 (tr) | 2000-07-21 |
Family
ID=27438596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/02775T TR199902775T2 (tr) | 1997-05-14 | 1998-05-04 | 20(S)-Kamptotesin glikokonjugeleri. |
Country Status (19)
Country | Link |
---|---|
US (1) | US6506734B1 (tr) |
EP (1) | EP0981542B1 (tr) |
JP (1) | JP2001526661A (tr) |
CN (1) | CN1255926A (tr) |
AT (1) | ATE272648T1 (tr) |
AU (1) | AU744425B2 (tr) |
BG (1) | BG103872A (tr) |
BR (1) | BR9809637A (tr) |
CA (1) | CA2291436A1 (tr) |
HU (1) | HUP0003174A3 (tr) |
ID (1) | ID23424A (tr) |
IL (1) | IL132534A0 (tr) |
NO (1) | NO995481D0 (tr) |
NZ (1) | NZ500990A (tr) |
PL (1) | PL336697A1 (tr) |
SK (1) | SK154899A3 (tr) |
TR (1) | TR199902775T2 (tr) |
TW (1) | TW495512B (tr) |
WO (1) | WO1998051703A1 (tr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19909979A1 (de) * | 1999-03-06 | 2000-09-07 | Bayer Ag | Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin |
DE10005275A1 (de) * | 2000-02-07 | 2001-08-09 | Bayer Ag | Neuartige Glycokonjugate |
EP1219634A1 (en) * | 2000-12-27 | 2002-07-03 | Bayer Aktiengesellschaft | Cytostatic-glycoconjugates having specifically cleavable peptidic linking units |
US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
EP1238678A1 (en) | 2001-03-08 | 2002-09-11 | Bayer Aktiengesellschaft | Enzyme-activated cytostatic conjugates with integrin ligands |
US6933302B2 (en) | 2002-06-03 | 2005-08-23 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
US7766293B2 (en) * | 2006-04-25 | 2010-08-03 | Raffel Systems, Llc | Lighted cup holder for seating arrangements |
WO2014152718A1 (en) | 2013-03-15 | 2014-09-25 | Arizona Board Of Regents, For And On Behalf Of Arizona State University | Saccharide conjugates |
EP2968381A4 (en) * | 2013-03-15 | 2016-11-30 | Sidney Hecht | MEDICAMENT CONJUGATES-SUGAR BINDING SEQUENCE |
CN103333172B (zh) * | 2013-06-28 | 2015-09-30 | 兰州大学 | 喜树碱缩氨基硫脲类化合物及其制备方法和用途 |
CN105566338B (zh) * | 2014-10-08 | 2017-11-21 | 兰州大学 | 一种喜树碱类化合物及其制备方法和用途 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JP2524803B2 (ja) | 1988-03-29 | 1996-08-14 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体およびその製造法 |
NZ235329A (en) * | 1989-09-15 | 1992-01-29 | Res Triangle Inst | 20(s or rs)-camptothecin derivatives and pharmaceutical compositions |
US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
DE4106101A1 (de) * | 1991-02-27 | 1992-09-03 | Bayer Ag | Fucose-markierte cytostatika |
JP3126799B2 (ja) | 1992-03-31 | 2001-01-22 | 第一製薬株式会社 | 光学活性カンプトテシン誘導体及びその製法 |
DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
JP2610792B2 (ja) * | 1993-02-26 | 1997-05-14 | 株式会社ディ・ディ・エス研究所 | 多糖誘導体および薬物担体 |
US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
US5496830A (en) | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
DE19512484A1 (de) * | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
PT934329E (pt) | 1996-09-30 | 2002-05-31 | Bayer Ag | Glicoconjugados de derivados de camptotecina modificados (ligacao 20-o) |
DE19640969A1 (de) * | 1996-10-04 | 1998-04-16 | Bayer Ag | 20-0-verknüpfte Glycokonjugate von Camptothecin |
-
1998
- 1998-04-05 ID IDW991361A patent/ID23424A/id unknown
- 1998-05-04 HU HU0003174A patent/HUP0003174A3/hu unknown
- 1998-05-04 CN CN98805102A patent/CN1255926A/zh active Pending
- 1998-05-04 NZ NZ500990A patent/NZ500990A/xx unknown
- 1998-05-04 EP EP98925527A patent/EP0981542B1/de not_active Expired - Lifetime
- 1998-05-04 JP JP54875198A patent/JP2001526661A/ja active Pending
- 1998-05-04 SK SK1548-99A patent/SK154899A3/sk unknown
- 1998-05-04 TR TR1999/02775T patent/TR199902775T2/tr unknown
- 1998-05-04 WO PCT/EP1998/002620 patent/WO1998051703A1/de not_active Application Discontinuation
- 1998-05-04 PL PL98336697A patent/PL336697A1/xx unknown
- 1998-05-04 AT AT98925527T patent/ATE272648T1/de not_active IP Right Cessation
- 1998-05-04 BR BR9809637-0A patent/BR9809637A/pt not_active IP Right Cessation
- 1998-05-04 AU AU77615/98A patent/AU744425B2/en not_active Ceased
- 1998-05-04 CA CA002291436A patent/CA2291436A1/en not_active Abandoned
- 1998-05-04 US US09/403,872 patent/US6506734B1/en not_active Expired - Fee Related
- 1998-05-14 IL IL13253498A patent/IL132534A0/xx unknown
- 1998-05-14 TW TW087107434A patent/TW495512B/zh active
-
1999
- 1999-11-09 NO NO995481A patent/NO995481D0/no not_active Application Discontinuation
- 1999-11-10 BG BG103872A patent/BG103872A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NZ500990A (en) | 2000-09-29 |
CA2291436A1 (en) | 1998-11-19 |
HUP0003174A2 (hu) | 2001-05-28 |
EP0981542A1 (de) | 2000-03-01 |
AU7761598A (en) | 1998-12-08 |
PL336697A1 (en) | 2000-07-03 |
JP2001526661A (ja) | 2001-12-18 |
ID23424A (id) | 2000-04-20 |
BG103872A (en) | 2000-07-31 |
BR9809637A (pt) | 2000-07-11 |
IL132534A0 (en) | 2001-03-19 |
CN1255926A (zh) | 2000-06-07 |
AU744425B2 (en) | 2002-02-21 |
US6506734B1 (en) | 2003-01-14 |
ATE272648T1 (de) | 2004-08-15 |
WO1998051703A1 (de) | 1998-11-19 |
NO995481L (no) | 1999-11-09 |
EP0981542B1 (de) | 2004-08-04 |
SK154899A3 (en) | 2000-08-14 |
HUP0003174A3 (en) | 2003-03-28 |
NO995481D0 (no) | 1999-11-09 |
TW495512B (en) | 2002-07-21 |
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