TR199900096T2 - Bradykinin B2 antagonistleri olarak elverisli N-benzensulfonil-L-prolin türevleri. - Google Patents

Bradykinin B2 antagonistleri olarak elverisli N-benzensulfonil-L-prolin türevleri.

Info

Publication number
TR199900096T2
TR199900096T2 TR1999/00096T TR9900096T TR199900096T2 TR 199900096 T2 TR199900096 T2 TR 199900096T2 TR 1999/00096 T TR1999/00096 T TR 1999/00096T TR 9900096 T TR9900096 T TR 9900096T TR 199900096 T2 TR199900096 T2 TR 199900096T2
Authority
TR
Turkey
Prior art keywords
group
pct
bradykinin
benzenesulfonyl
antagonists
Prior art date
Application number
TR1999/00096T
Other languages
English (en)
Inventor
Dodey Pierre
Bondoux Michel
Houziaux Patrick
Barth Martine
Ou Khan
Original Assignee
Fournier Industrie Et Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Industrie Et Sante filed Critical Fournier Industrie Et Sante
Publication of TR199900096T2 publication Critical patent/TR199900096T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Formül (1).Yukaridaki formül (I) bilesiklerinden olusan gruptan seçilen bilesikler ve bunlarin ilave tuzlari; burada ayni veya farkli olan her X1 ve X2 halojen veya bir C1-3 alkoksi grubudur;R1 H, CF3 veya bir C1-3 alkil grubudur; R2 bir hidrojen atomu veya bir OH grubudur; A grup (a), (b) veya (c9 dir; B tek bir bag (Devami var.)
TR1999/00096T 1996-07-24 1997-07-23 Bradykinin B2 antagonistleri olarak elverisli N-benzensulfonil-L-prolin türevleri. TR199900096T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609327A FR2751650B1 (fr) 1996-07-24 1996-07-24 Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique

Publications (1)

Publication Number Publication Date
TR199900096T2 true TR199900096T2 (tr) 1999-03-22

Family

ID=9494439

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00096T TR199900096T2 (tr) 1996-07-24 1997-07-23 Bradykinin B2 antagonistleri olarak elverisli N-benzensulfonil-L-prolin türevleri.

Country Status (14)

Country Link
US (1) US6071917A (tr)
EP (1) EP0925295B1 (tr)
JP (1) JP2000514818A (tr)
AT (1) ATE206419T1 (tr)
AU (1) AU3853697A (tr)
CA (1) CA2261743A1 (tr)
DE (1) DE69707141T2 (tr)
DK (1) DK0925295T3 (tr)
ES (1) ES2167768T3 (tr)
FR (1) FR2751650B1 (tr)
PL (1) PL186396B1 (tr)
PT (1) PT925295E (tr)
TR (1) TR199900096T2 (tr)
WO (1) WO1998003503A1 (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2765222B1 (fr) * 1997-06-27 1999-12-31 Fournier Ind & Sante Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
KR100579792B1 (ko) * 1998-05-13 2006-05-12 동화약품공업주식회사 신규 2,5-피리딘디카복실산 유도체
FR2790260B1 (fr) * 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
CA2364178C (en) * 2000-12-05 2006-01-10 Yasuhiro Katsu N-benzenesulfonyl l-proline compounds as bradykinin antagonists
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
FR2840897B1 (fr) * 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
DE10304994A1 (de) * 2003-02-07 2004-09-02 Aventis Pharma Deutschland Gmbh Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose
EA008921B1 (ru) 2003-03-25 2007-08-31 Лаборатуар Фурнье С.А. Производные бензолсульфонамидов, способ их получения и их применение для лечения боли
DE102005013967A1 (de) * 2004-11-05 2006-10-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
CN1168667A (zh) * 1994-10-27 1997-12-24 藤沢药品工业株式会社 用作缓激肽拮抗剂的吡啶并嘧啶酮，喹啉和稠合的n-杂环化合物
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
FR2743073B1 (fr) * 1995-12-29 1998-02-20 Fournier Ind & Sante Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
PL186396B1 (pl) 2004-01-30
ATE206419T1 (de) 2001-10-15
PT925295E (pt) 2002-03-28
EP0925295A1 (fr) 1999-06-30
FR2751650A1 (fr) 1998-01-30
PL331347A1 (en) 1999-07-05
DE69707141D1 (de) 2001-11-08
WO1998003503A1 (fr) 1998-01-29
DE69707141T2 (de) 2002-06-27
FR2751650B1 (fr) 1998-10-09
ES2167768T3 (es) 2002-05-16
JP2000514818A (ja) 2000-11-07
CA2261743A1 (en) 1998-01-29
AU3853697A (en) 1998-02-10
DK0925295T3 (da) 2002-01-28
US6071917A (en) 2000-06-06
EP0925295B1 (fr) 2001-10-04

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