DE60000405T2 - 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression - Google Patents

1,4-disubstitutierte cyclohexanderivate zur behandlung von depression

Info

Publication number
DE60000405T2
DE60000405T2 DE60000405T DE60000405T DE60000405T2 DE 60000405 T2 DE60000405 T2 DE 60000405T2 DE 60000405 T DE60000405 T DE 60000405T DE 60000405 T DE60000405 T DE 60000405T DE 60000405 T2 DE60000405 T2 DE 60000405T2
Authority
DE
Germany
Prior art keywords
hydrogen
halogen
alkyl
treating depression
cyclohexane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60000405T
Other languages
English (en)
Other versions
DE60000405D1 (de
Inventor
Richard Eric Mewshaw
Bernhard Baudy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60000405D1 publication Critical patent/DE60000405D1/de
Publication of DE60000405T2 publication Critical patent/DE60000405T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60000405T 1999-01-07 2000-01-06 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression Expired - Fee Related DE60000405T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22655299A 1999-01-07 1999-01-07
PCT/US2000/000348 WO2000040579A1 (en) 1999-01-07 2000-01-06 New 1,4-disubstituted cyclohexane derivatives for the treatment of depression

Publications (2)

Publication Number Publication Date
DE60000405D1 DE60000405D1 (de) 2002-10-10
DE60000405T2 true DE60000405T2 (de) 2003-08-07

Family

ID=22849378

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000405T Expired - Fee Related DE60000405T2 (de) 1999-01-07 2000-01-06 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression

Country Status (11)

Country Link
EP (1) EP1140919B1 (de)
JP (1) JP2002534426A (de)
CN (1) CN1335844A (de)
AT (1) ATE223406T1 (de)
AU (1) AU2494400A (de)
CA (1) CA2355361A1 (de)
DE (1) DE60000405T2 (de)
DK (1) DK1140919T3 (de)
ES (1) ES2182775T3 (de)
PT (1) PT1140919E (de)
WO (1) WO2000040579A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12012003A3 (en) 2001-03-29 2004-10-05 Bristol Myers Squibb Co Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
CN100391974C (zh) * 2006-01-09 2008-06-04 浙江理工大学 一种重组胶原蛋白及其合成和表达纯化方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3907974A1 (de) * 1989-03-11 1990-09-13 Merck Patent Gmbh Indolderivate
US4975445A (en) * 1989-12-06 1990-12-04 Warner-Lambert Company Substituted cyclohexenes as central nervous system agents
US5322851A (en) * 1990-07-02 1994-06-21 H. Lundbeck A/S Indole derivatives
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
GB9300194D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
NZ305166A (en) * 1995-03-20 1998-12-23 Lilly Co Eli 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds

Also Published As

Publication number Publication date
AU2494400A (en) 2000-07-24
JP2002534426A (ja) 2002-10-15
WO2000040579A1 (en) 2000-07-13
CA2355361A1 (en) 2000-07-13
PT1140919E (pt) 2002-12-31
EP1140919B1 (de) 2002-09-04
DE60000405D1 (de) 2002-10-10
ES2182775T3 (es) 2003-03-16
ATE223406T1 (de) 2002-09-15
DK1140919T3 (da) 2002-12-30
EP1140919A1 (de) 2001-10-10
CN1335844A (zh) 2002-02-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee