ES2167768T3 - Derivados de n-bencenosulfonil-l-prolina como antagonistas del receptor b2 de la bradiquinina. - Google Patents

Derivados de n-bencenosulfonil-l-prolina como antagonistas del receptor b2 de la bradiquinina.

Info

Publication number
ES2167768T3
ES2167768T3 ES97935612T ES97935612T ES2167768T3 ES 2167768 T3 ES2167768 T3 ES 2167768T3 ES 97935612 T ES97935612 T ES 97935612T ES 97935612 T ES97935612 T ES 97935612T ES 2167768 T3 ES2167768 T3 ES 2167768T3
Authority
ES
Spain
Prior art keywords
group
pct
bencenosulfonil
bradiquinine
prolina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97935612T
Other languages
English (en)
Inventor
Pierre Dodey
Michel Bondoux
Patrick Houziaux
Martine Barth
Khan Ou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Industrie et Sante SAS
Original Assignee
Fournier Industrie et Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Application granted granted Critical
Publication of ES2167768T3 publication Critical patent/ES2167768T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS ELEGIDOS ENTRE EL CONJUNTO CONSTITUIDO POR (I) LOS COMPUESTOS DE FORMULA (I) EN LA QUE X 1 Y X 2 REPRESENTAN CADA UNO INDEPENDIENTEMENTE UN HALOGENO O UN GRUPO ALCOXILO DE C 1 - C SU B,3 , R 1 REPRESENTA H, CF 3 O UN GRUPO ALQUILO DE C1 C 3 , R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO OH, A REPRESENTA UN GRUPO (A), (B) O (C); B REPRESENTA UN ENLACE SIMPLE, -CO-, -CO - CH 2 -, -CO - CH 2 O-, -CO - CH = CH O -SO 2 -, M REPRESENTA 2 O 3 , N REPRES ENTA 0, 1, 2 O 3, R 3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO METILO, W REPRESENTA CH O N, ESTANDO EL GRUPO AMIDINA C ( =NR 2 ) NH 2 EN POSICION 2, 3 O 4 EN EL NUCLEO AROMATICO Y (II) SUS SALES DE ADICION. LA INVENCION SE REFIERE TAMBIEN A SU PROCEDIMIENTO DE PREPARACION Y A SU UTILIZACION TERAPEUTICA, PARTICULARMENTE RESPECTO A PATOLOGIAS EN LAS QUE SE UTILIZA LA BRADIQUININA.
ES97935612T 1996-07-24 1997-07-23 Derivados de n-bencenosulfonil-l-prolina como antagonistas del receptor b2 de la bradiquinina. Expired - Lifetime ES2167768T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609327A FR2751650B1 (fr) 1996-07-24 1996-07-24 Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique

Publications (1)

Publication Number Publication Date
ES2167768T3 true ES2167768T3 (es) 2002-05-16

Family

ID=9494439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97935612T Expired - Lifetime ES2167768T3 (es) 1996-07-24 1997-07-23 Derivados de n-bencenosulfonil-l-prolina como antagonistas del receptor b2 de la bradiquinina.

Country Status (14)

Country Link
US (1) US6071917A (es)
EP (1) EP0925295B1 (es)
JP (1) JP2000514818A (es)
AT (1) ATE206419T1 (es)
AU (1) AU3853697A (es)
CA (1) CA2261743A1 (es)
DE (1) DE69707141T2 (es)
DK (1) DK0925295T3 (es)
ES (1) ES2167768T3 (es)
FR (1) FR2751650B1 (es)
PL (1) PL186396B1 (es)
PT (1) PT925295E (es)
TR (1) TR199900096T2 (es)
WO (1) WO1998003503A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2765222B1 (fr) * 1997-06-27 1999-12-31 Fournier Ind & Sante Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
KR100579792B1 (ko) 1998-05-13 2006-05-12 동화약품공업주식회사 신규 2,5-피리딘디카복실산 유도체
FR2790260B1 (fr) * 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
CA2364178C (en) * 2000-12-05 2006-01-10 Yasuhiro Katsu N-benzenesulfonyl l-proline compounds as bradykinin antagonists
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
FR2840897B1 (fr) * 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
DE10304994A1 (de) * 2003-02-07 2004-09-02 Aventis Pharma Deutschland Gmbh Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose
AU2004226197B2 (en) 2003-03-25 2009-12-03 Laboratoires Fournier S.A. Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain
DE102005013967A1 (de) * 2004-11-05 2006-10-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
ES2218554T3 (es) * 1994-10-27 2004-11-16 Fujisawa Pharmaceutical Co., Ltd. Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina.
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
FR2743073B1 (fr) * 1995-12-29 1998-02-20 Fournier Ind & Sante Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
FR2751650A1 (fr) 1998-01-30
EP0925295B1 (fr) 2001-10-04
WO1998003503A1 (fr) 1998-01-29
PT925295E (pt) 2002-03-28
US6071917A (en) 2000-06-06
CA2261743A1 (en) 1998-01-29
FR2751650B1 (fr) 1998-10-09
DE69707141D1 (de) 2001-11-08
AU3853697A (en) 1998-02-10
JP2000514818A (ja) 2000-11-07
ATE206419T1 (de) 2001-10-15
TR199900096T2 (xx) 1999-03-22
DE69707141T2 (de) 2002-06-27
PL186396B1 (pl) 2004-01-30
DK0925295T3 (da) 2002-01-28
PL331347A1 (en) 1999-07-05
EP0925295A1 (fr) 1999-06-30

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