TR199800415T1 - Farmasötik formülasyon. - Google Patents

Farmasötik formülasyon.

Info

Publication number
TR199800415T1
TR199800415T1 TR1998/00415T TR9800415T TR199800415T1 TR 199800415 T1 TR199800415 T1 TR 199800415T1 TR 1998/00415 T TR1998/00415 T TR 1998/00415T TR 9800415 T TR9800415 T TR 9800415T TR 199800415 T1 TR199800415 T1 TR 199800415T1
Authority
TR
Turkey
Prior art keywords
lasyon
farmas
tik
drsp
clavulanate
Prior art date
Application number
TR1998/00415T
Other languages
English (en)
Inventor
Joseph Burch Daniel
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21705455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR199800415(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR199800415T1 publication Critical patent/TR199800415T1/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

10:1 ila 20:1 oraninda amoksisilin ve klavulanat içeren formülasyonlar DRSP nin sebep olma ihtimali olan enfeksiyonlarin ampirik olarak tedavisinde kullanilirlar.
TR1998/00415T 1995-09-07 1996-09-05 Farmasötik formülasyon. TR199800415T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US335395P 1995-09-07 1995-09-07

Publications (1)

Publication Number Publication Date
TR199800415T1 true TR199800415T1 (tr) 1998-05-21

Family

ID=21705455

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00415T TR199800415T1 (tr) 1995-09-07 1996-09-05 Farmasötik formülasyon.

Country Status (28)

Country Link
US (3) US6726908B2 (tr)
EP (3) EP0862431B1 (tr)
JP (1) JP3501289B2 (tr)
KR (1) KR100495585B1 (tr)
CN (1) CN1289084C (tr)
AR (1) AR004510A1 (tr)
AT (1) ATE208618T1 (tr)
AU (1) AU711441B2 (tr)
BR (1) BR9610396A (tr)
CA (1) CA2231194C (tr)
CO (1) CO4750658A1 (tr)
CY (1) CY2359B1 (tr)
CZ (1) CZ299595B6 (tr)
DE (1) DE69617036T2 (tr)
DK (1) DK0862431T3 (tr)
ES (1) ES2165997T3 (tr)
HK (2) HK1015701A1 (tr)
HU (1) HUP9901437A3 (tr)
IL (1) IL123563A (tr)
NO (1) NO314831B1 (tr)
NZ (3) NZ337247A (tr)
PL (1) PL325411A1 (tr)
PT (1) PT862431E (tr)
SI (1) SI0862431T1 (tr)
TR (1) TR199800415T1 (tr)
TW (1) TW501926B (tr)
WO (1) WO1997009042A1 (tr)
ZA (1) ZA967546B (tr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109503A1 (en) * 1995-06-06 2003-06-12 Smithkline Beecham P.L.C. Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
KR100495585B1 (ko) * 1995-09-07 2005-09-09 스미스클라인비이참피이엘시이 제약 제제
GB9617780D0 (en) * 1996-08-24 1996-10-02 Smithkline Beecham Plc Method of treatment
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
PL197448B1 (pl) * 1999-04-13 2008-03-31 Beecham Pharm Pte Ltd Preparat farmaceutyczny o zmodyfikowanym uwalnianiu zawierający amoksycylinę i klawulanian potasowy oraz zastosowanie amoksycyliny i klawulanianu potasowego
GB2365337A (en) * 1999-04-13 2002-02-20 Beecham Pharma Amoxycillin and potassium clavulanate high dosage regimen
US6294199B1 (en) * 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
WO2001000177A1 (en) * 1999-06-29 2001-01-04 Micio Pharma Chemical Aktiengesellschaft Retard formulation of amoxicillin for oral administration
US6955821B2 (en) 2000-04-28 2005-10-18 Adams Laboratories, Inc. Sustained release formulations of guaifenesin and additional drug ingredients
US8012504B2 (en) 2000-04-28 2011-09-06 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
US7838032B2 (en) 2000-04-28 2010-11-23 Reckitt Benckiser Inc. Sustained release of guaifenesin
US7985420B2 (en) 2000-04-28 2011-07-26 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
WO2002030392A2 (en) 2000-10-12 2002-04-18 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
EP1492511B3 (fr) 2002-04-09 2012-05-02 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
KR100456833B1 (ko) * 2002-08-01 2004-11-10 주식회사 대웅 아목시실린 및 클라불라네이트를 함유하는 유핵정
US8614315B2 (en) 2009-12-25 2013-12-24 Mahmut Bilgic Cefdinir and cefixime formulations and uses thereof
TR200909787A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Üçüncü kuşak bir sefalosporin ve klavulanik asit içeren farmasötik formülasyonlar.
TR201000688A2 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar.
TR201000686A1 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@
TR201000687A1 (tr) 2010-01-29 2011-08-22 Bi̇lgi̇ç Mahmut Aktif madde olarak sefiksim ve klavulanik asit içeren efervesan formülasyonlar
WO2013057569A2 (en) 2011-10-19 2013-04-25 Micro Labs Limited Extended release pharmaceutical composition containing amoxicillin and clavulanic acid
KR20140117523A (ko) * 2012-01-10 2014-10-07 마이클 스펙터 아목시실린 및 클라불란산 칼륨의 소아용 경구 현탁 제형 및 이를 사용하기 위한 방법
WO2013173808A2 (en) * 2012-05-17 2013-11-21 Michael Spector Methods for use of lower dose compositions of amoxicillin and clavulanate potassium and devices for use
WO2013173803A2 (en) * 2012-05-17 2013-11-21 Michael Spector Formulations of amoxicillin and clavulanate potassium and methods for using same
EP3364955B1 (en) 2015-10-09 2022-04-20 RB Health (US) LLC Pharmaceutical formulation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
JO984B1 (en) 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
IL58461A0 (en) 1978-10-27 1980-01-31 Beecham Group Ltd Intramammary compositions comprising a clavulanic acid salt
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
EP0080862B1 (en) * 1981-12-02 1985-09-25 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
US4673637A (en) 1984-04-23 1987-06-16 Hyman Edward S Method for detecting bacteria in urine and for treating rheumatoid arthritis, essential hypertension and other diseases associated with bacteriuria
EP0281200B1 (en) 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmaceutical composition, pharmaceutical granulate and process for their preparation
US5114929A (en) * 1989-03-21 1992-05-19 Beecham Group P.L.C. Pharmaceutical formulation
GB8909793D0 (en) 1989-04-28 1989-06-14 Beecham Group Plc Pharmaceutical formulation
KR910009271B1 (ko) 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
US5814337A (en) 1992-10-07 1998-09-29 Beecham Group Plc Pharmaceutical formulation
GB9007945D0 (en) * 1990-04-07 1990-06-06 Beecham Group Plc Pharmaceutical formulation
GB9109862D0 (en) 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
GB9114950D0 (en) 1991-07-11 1991-08-28 Smithkline Beecham Plc Pharmaceutical formulation
JPH08505868A (ja) * 1993-01-22 1996-06-25 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー クラブラン酸のみまたは他のベータ−ラクタム抗生物質と混合されたクラブラン酸からなる薬剤処方
GB9311030D0 (en) 1993-05-28 1993-07-14 Smithkline Beecham Corp Pharmaceutical formulations
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby
GB9405856D0 (en) 1994-03-24 1994-05-11 Smithkline Beecham Plc Pharmaceutical formulation
GB9407386D0 (en) 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
GB9408117D0 (en) 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
ITMI941169A1 (it) 1994-06-06 1995-12-06 Smithkline Beecham Farma Formulazioni farmaceutiche
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
GB9416599D0 (en) 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
GB9416600D0 (en) 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
DZ1926A1 (fr) 1994-09-03 2002-02-17 Smithkline Beckman P L C Formulations pharmaceutiques.
DZ2028A1 (fr) 1995-05-03 2002-10-23 Smithkline Beecham Plc Médicaments destinés au traitement d'infections bactériennes en pédiatrie.
US5830073A (en) 1995-07-28 1998-11-03 Voss; Brian C. Bowling lane surfaces
KR100495585B1 (ko) * 1995-09-07 2005-09-09 스미스클라인비이참피이엘시이 제약 제제
EP0975342B1 (en) 1997-02-14 2003-06-25 Laboratoire GlaxoSmithKline S.A.S. Pharmaceutical formulations comprising amoxocyllin and clavulanate
SE9700885D0 (sv) 1997-03-12 1997-03-12 Astra Ab New pharmaceutical formulation
ID22340A (id) 1997-03-25 1999-09-30 Takeda Chemical Industries Ltd Komposisi farmasi lekat-mukosa saluran pencernaan
GB9815532D0 (en) 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
GB9818927D0 (en) 1998-08-28 1998-10-21 Smithkline Beecham Plc Pharmaceutical formulation
PL197448B1 (pl) * 1999-04-13 2008-03-31 Beecham Pharm Pte Ltd Preparat farmaceutyczny o zmodyfikowanym uwalnianiu zawierający amoksycylinę i klawulanian potasowy oraz zastosowanie amoksycyliny i klawulanianu potasowego

Also Published As

Publication number Publication date
BR9610396A (pt) 1999-07-06
AU6973396A (en) 1997-03-27
EP1093812A3 (en) 2001-06-06
AR004510A1 (es) 1998-12-16
DK0862431T3 (da) 2002-03-11
HUP9901437A3 (en) 2000-03-28
AU711441B2 (en) 1999-10-14
DE69617036T2 (de) 2002-07-11
EP0862431A1 (en) 1998-09-09
MX9801903A (es) 1998-05-31
WO1997009042A1 (en) 1997-03-13
JPH11512398A (ja) 1999-10-26
HUP9901437A2 (hu) 1999-09-28
CZ299595B6 (cs) 2008-09-17
JP3501289B2 (ja) 2004-03-02
NO981008D0 (no) 1998-03-06
ZA967546B (en) 1998-03-06
PT862431E (pt) 2002-04-29
EP0862431A4 (en) 1999-07-07
NZ337247A (en) 2001-05-25
CA2231194C (en) 2004-07-20
CN1289084C (zh) 2006-12-13
CZ68398A3 (cs) 1998-07-15
NO314831B1 (no) 2003-06-02
US20010038838A1 (en) 2001-11-08
ATE208618T1 (de) 2001-11-15
EP1147771A1 (en) 2001-10-24
NO981008L (no) 1998-05-06
DE69617036D1 (de) 2001-12-20
SI0862431T1 (en) 2002-06-30
KR19990044495A (ko) 1999-06-25
EP0862431B1 (en) 2001-11-14
HK1043042A1 (zh) 2002-09-06
NZ318282A (en) 2000-01-28
ES2165997T3 (es) 2002-04-01
CO4750658A1 (es) 1999-03-31
IL123563A (en) 2002-02-10
US6726908B2 (en) 2004-04-27
KR100495585B1 (ko) 2005-09-09
PL325411A1 (en) 1998-07-20
CA2231194A1 (en) 1997-03-13
EP1093812A2 (en) 2001-04-25
NZ337246A (en) 2000-07-28
US20050261267A1 (en) 2005-11-24
CN1200672A (zh) 1998-12-02
US20010043926A1 (en) 2001-11-22
CY2359B1 (en) 2004-06-04
HK1015701A1 (en) 1999-10-22
TW501926B (en) 2002-09-11

Similar Documents

Publication Publication Date Title
TR199800415T1 (tr) Farmasötik formülasyon.
MX9803648A (es) Composiciones y metodos para mejorar el desempeño de productos cosmeticos de uso prolongado.
NO971889D0 (no) Forbindelser og sammensetninger for levering av aktive midler
BG99261A (en) Steroid glycosides for the treatment of hyperchlesterolemia
MY121294A (en) Novel hexanoic acid derivatives.
BG103664A (en) Pharmaceutical forms containing ammoxycillin and clavulanate
LU91223I2 (fr) Ivabradine et ses dérivés pharmaceutiquement acceptables (procoralan)
FI971536A (fi) Keratinosyytti-kasvutekijän analogeja
ATE321534T1 (de) Verbesserte liposomale formulierung
FR2702148B1 (fr) Application d'anticonvulsivants dans le traitement du neuro-sida.
MX9400434A (es) Potenciamiento de temozolomida en celulas de tumores humanos.
ATE164159T1 (de) Substituierte triole
MY133125A (en) Novel dihydroxyhexanoic acid derivatives
AU1711197A (en) Method for treating sexual dysfunctions
BR9408023A (pt) Formulações de fenbendazol
AU8332791A (en) Oral pharmaceutical compositions containing melatonin
ATE183385T1 (de) Lyopilisierte, wirkstoffhaltige emulsion
PL314800A1 (en) Application of dimeticone in treating aphthae and oral cavity inflammations
MD960168A (ro) Metodă şi compuşi pentru tratamentul infecţiilor virale
ATE195055T1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
PL314799A1 (en) Application of dimeticone in treating constipations
MX9603087A (es) Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas.
BG101526A (en) Antiphlogistic composition for external application
TR200103126T2 (tr) Yapısal titremenin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri
MX9700626A (es) USO DE AZASPIRANOS EN LA REPARACIaN DE COMPOSICIONES PARA TRATAR INFECCIONES OPORTUNISTAS.