TNSN89120A1 - Derives de l'acide penicillanique - Google Patents

Derives de l'acide penicillanique

Info

Publication number
TNSN89120A1
TNSN89120A1 TNTNSN89120A TNSN89120A TNSN89120A1 TN SN89120 A1 TNSN89120 A1 TN SN89120A1 TN TNSN89120 A TNTNSN89120 A TN TNSN89120A TN SN89120 A TNSN89120 A TN SN89120A TN SN89120 A1 TNSN89120 A1 TN SN89120A1
Authority
TN
Tunisia
Prior art keywords
group
heterocycle
hydrogen
alkyle
aryl
Prior art date
Application number
TNTNSN89120A
Other languages
English (en)
Inventor
Joseph Bartkovitz David
Dalton Keith Dannis
Mook Robert
Wei Chung-Chen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TNSN89120A1 publication Critical patent/TNSN89120A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LES COMPOSES DE FORMULE GENERALE, DANS LAQUELLE R EST UN HYDROGENE, UN GROUPE ESTER FACILEMENT HYDROLYSABLE OU UN GROUPE PROTECTEUR, R1 EST UN HYDROGENE ET R2 EST UN HYDROGENE OU UN GROUPE ACYLE, OU R1 ET R2, PRIS CONJOINTEMENT, SONT LE GROUPE, DANS LEQUEL N EST EGAL A 5, 6 OU 7, X EST UN GROUPE FLUORO, THIOACYANATO, AZIDO OU LE GROUPE R3ACO2-, R3A EST UN GROUPE ALKYLE EN C2 A C16, UN GROUP ARYLE, UN HETEROCYCLE, UN GROUPE - (CH2)m-ARYLE, -(CH2)m-HETEROCYCLE, HETEROCYCLE- ALCENYLE INFERIEUR OU ARYLE-ALCENYLE INFERIEUR, R3 EST UN GROUPE ALKYLE EN C1 A C16, UN GROUPE ARYLE, UN HETEROCYCLE, UN GROUPE -(CH2)m-ARYLE, - (CH2)m-HETEROCYCLE, HETEROCYCLE-ALCENYLE INFERIEUR OU ARYLE-ALCENYLE INFERIEUR, R4 ET R4' SONT CHACUN INDEPENDAMMENT UN HYDROGENE, UN GROUPE ALKYLE INFERIEUR, ALCENYLE INFERIEUR OU ALCYNYLE INFERIEUR, Ra EST UN HYDROGENE, UN HALOGENE, UN GROUPE AMINO, AMINO-ALKYLE INFERIEUR, CARBOXY, CARBAMOYLE, CARBOXY-ALKYLE INFERIEUR, CARBAMOYL-ALKYLE INFERIEUR OU CARBALCOXY INFERIEUR-ALKYLE INFERIEUR, m VAUT DE 1 A 4 ET P VAUT 3, 4 OU 5, A CONDITION QUE X SOIT AUTRE QU'UN FLUORO LORSQUE R EST UN GROUPE PROTECTEUR, UN HYDRATE, UN ESTER FACILEMENT HYDROLYSABLE OU UN SEL DE CES COMPOSES, OU UN HYDRATE DE L'ESTER OU DU SEL, LORSQUE R EST UN HYDROGENE, SONT UTILES COMME AGENTS ANTIBACTERIENS POUR LA PREVENTION ET LE TRAITEMENT DES INFECTIONS BACTERIENNES CHEZ LES MAMMIFERES, Y COMPRIS LES HOMMES
TNTNSN89120A 1988-10-31 1989-10-31 Derives de l'acide penicillanique TNSN89120A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26516188A 1988-10-31 1988-10-31
US41618689A 1989-10-02 1989-10-02

Publications (1)

Publication Number Publication Date
TNSN89120A1 true TNSN89120A1 (fr) 1991-02-04

Family

ID=26951020

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN89120A TNSN89120A1 (fr) 1988-10-31 1989-10-31 Derives de l'acide penicillanique

Country Status (16)

Country Link
EP (1) EP0367124A1 (fr)
JP (1) JPH02191283A (fr)
KR (1) KR900006345A (fr)
CN (1) CN1047504A (fr)
AU (1) AU4389289A (fr)
CA (1) CA2001642A1 (fr)
DK (1) DK538689A (fr)
FI (1) FI895162A0 (fr)
HU (1) HUT52102A (fr)
IL (1) IL92139A0 (fr)
MC (1) MC2069A1 (fr)
NO (1) NO894322L (fr)
OA (1) OA09142A (fr)
PT (1) PT92156A (fr)
TN (1) TNSN89120A1 (fr)
ZW (1) ZW13589A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69225821T2 (de) * 1991-03-13 1998-11-05 Otsuka Kagaku Kk Penamderivate und Verfahren zu deren Herstellung
SI2046802T1 (sl) * 2006-07-12 2014-03-31 Allecra Therapeutics Gmbh C/O Loeba Treuhand Gmbh 2-substituirani metil penamski derivati
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3466275A (en) * 1962-07-31 1969-09-09 Lilly Co Eli Modified penicillins and their preparation via penicillin sulfoxides
US3989685A (en) * 1972-06-29 1976-11-02 Shinogi & Co., Ltd. Process for making a 2'-halopenicillin
SE417968B (sv) * 1972-10-20 1981-04-27 Fujisawa Pharmaceutical Co Forfarande for framstellning av penamderivat
US4081443A (en) * 1976-01-29 1978-03-28 Shionogi & Co., Ltd. Penicillin oxides
GB1575415A (en) * 1976-12-31 1980-09-24 Connlab Holdings Ltd Process for preparing 2-acyloxymethyl-penams and 3-acloxycephams
US4322347A (en) * 1978-04-03 1982-03-30 Bristol-Myers Company 2-Carbamoyloxymethyl-penicillin derivatives
US4464237A (en) * 1982-08-09 1984-08-07 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing β-lactam derivatives
EP0206000A1 (fr) * 1985-06-01 1986-12-30 F. Hoffmann-La Roche Ag Acides (2,3)-alpha-méthylènepénam-3-carboxyliques et leurs dérivés
GB8709666D0 (en) * 1987-04-23 1987-05-28 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
ZW13589A1 (en) 1990-06-13
PT92156A (pt) 1990-05-31
NO894322L (no) 1990-05-02
JPH02191283A (ja) 1990-07-27
HUT52102A (en) 1990-06-28
IL92139A0 (en) 1990-07-12
CN1047504A (zh) 1990-12-05
EP0367124A1 (fr) 1990-05-09
OA09142A (fr) 1991-10-31
DK538689A (da) 1990-05-01
DK538689D0 (da) 1989-10-27
AU4389289A (en) 1990-05-03
CA2001642A1 (fr) 1990-04-30
FI895162A0 (fi) 1989-10-31
KR900006345A (ko) 1990-05-08
MC2069A1 (fr) 1990-10-03
NO894322D0 (no) 1989-10-30

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