SU578890A3 - Способ получени производных цефалоспорина или их солей - Google Patents
Способ получени производных цефалоспорина или их солейInfo
- Publication number
- SU578890A3 SU578890A3 SU7602335246A SU2335246A SU578890A3 SU 578890 A3 SU578890 A3 SU 578890A3 SU 7602335246 A SU7602335246 A SU 7602335246A SU 2335246 A SU2335246 A SU 2335246A SU 578890 A3 SU578890 A3 SU 578890A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- acetamido
- oxo
- thia
- salts
- aza
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title description 7
- 238000000034 method Methods 0.000 title description 3
- 229930186147 Cephalosporin Natural products 0.000 title description 2
- 229940124587 cephalosporin Drugs 0.000 title description 2
- 150000001780 cephalosporins Chemical class 0.000 title description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- -1 organic acid salt Chemical class 0.000 description 8
- 241000534944 Thia Species 0.000 description 7
- 239000000047 product Substances 0.000 description 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- YNKRJGZPPAUPLQ-UHFFFAOYSA-N 2-methylsulfonyl-1h-imidazole Chemical compound CS(=O)(=O)C1=NC=CN1 YNKRJGZPPAUPLQ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001417516 Haemulidae Species 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000007998 bicine buffer Substances 0.000 description 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7415226A FR2269348A1 (en) | 1974-05-02 | 1974-05-02 | 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU578890A3 true SU578890A3 (ru) | 1977-10-30 |
Family
ID=9138377
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762335245A SU593668A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
| SU7602335246A SU578890A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762335245A SU593668A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR207604A1 (enrdf_load_stackoverflow) |
| AT (1) | AT336791B (enrdf_load_stackoverflow) |
| BE (1) | BE828631A (enrdf_load_stackoverflow) |
| CH (1) | CH601318A5 (enrdf_load_stackoverflow) |
| CS (1) | CS188226B2 (enrdf_load_stackoverflow) |
| ES (1) | ES441745A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2269348A1 (enrdf_load_stackoverflow) |
| SU (2) | SU593668A3 (enrdf_load_stackoverflow) |
| ZA (1) | ZA752798B (enrdf_load_stackoverflow) |
-
1974
- 1974-05-02 FR FR7415226A patent/FR2269348A1/fr active Granted
-
1975
- 1975-01-01 AR AR261526A patent/AR207604A1/es active
- 1975-04-30 CS CS753027A patent/CS188226B2/cs unknown
- 1975-04-30 ZA ZA00752798A patent/ZA752798B/xx unknown
- 1975-04-30 BE BE155993A patent/BE828631A/xx unknown
- 1975-05-01 CH CH993677A patent/CH601318A5/xx not_active IP Right Cessation
- 1975-05-02 AT AT337575A patent/AT336791B/de not_active IP Right Cessation
- 1975-10-13 ES ES75441745A patent/ES441745A1/es not_active Expired
-
1976
- 1976-03-25 SU SU762335245A patent/SU593668A3/ru active
- 1976-03-25 SU SU7602335246A patent/SU578890A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| AT336791B (de) | 1977-05-25 |
| FR2269348B1 (enrdf_load_stackoverflow) | 1977-11-10 |
| FR2269348A1 (en) | 1975-11-28 |
| AR207604A1 (es) | 1976-10-15 |
| CH601318A5 (enrdf_load_stackoverflow) | 1978-07-14 |
| SU593668A3 (ru) | 1978-02-15 |
| ZA752798B (en) | 1976-04-28 |
| ATA337575A (de) | 1976-09-15 |
| CS188226B2 (en) | 1979-02-28 |
| ES441745A1 (es) | 1977-03-16 |
| BE828631A (fr) | 1975-10-30 |
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