SU468422A3 - The method of producing pyrimidine derivatives - Google Patents
The method of producing pyrimidine derivativesInfo
- Publication number
- SU468422A3 SU468422A3 SU1939807A SU1939807A SU468422A3 SU 468422 A3 SU468422 A3 SU 468422A3 SU 1939807 A SU1939807 A SU 1939807A SU 1939807 A SU1939807 A SU 1939807A SU 468422 A3 SU468422 A3 SU 468422A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pyrimidine derivatives
- producing
- producing pyrimidine
- general formula
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ПИРИМИДИНА(54) METHOD FOR PRODUCING PYRIMIDINE DERIVATIVES
1. .. . one. .. .
Предлагаетс способ получени новых производных пирим1адина, которые про вл ют биологическую активность и обладают лучшими свойствами по сравнению с их ближайшими аналогами.A method is proposed for producing new pyrimidine derivatives that exhibit biological activity and have better properties than their closest analogues.
В органической химии известна реакци ашширювани 2,6-аминопроизводных пиримидина галогенангидридами карбоновых кислот.In organic chemistry, the reaction of the cross-linking of 2,6-amino derivatives of pyrimidine with carboxylic acid halides is known.
Предлагаетс основанный на известной реакции способ получени новых производных пиримидина обшей формулы 1A method for the preparation of new pyrimidine derivatives of the general formula 1 based on the known reaction is proposed.
или их солей, заключающийс в том, что пириметамин формулыor their salts, the pyrimethamine of formula
обрабатывают соединением общей формулы 2treated with a compound of General formula 2
гС-Вз GS-Bz
15 О15 o
MWiMWi
где R и R - каждый означает дипропила-. цетил, трипропилацетил, 2-этил-2-бутилацетил , 2-метил-2-фенилацетил, причем 1where R and R - each means dipropila-. cetyl, tripropyl acetyl, 2-ethyl-2-butylacetyl, 2-methyl-2-phenylacetyl, and 1
может также быть атомом водорода или | 2-метил-2-фенилацетилом,Jmay also be a hydrogen atom or | 2-methyl-2-phenylacetyl, J
где R означает 2-,3- или 4-гептил или 4-(4-пропш1) гептил;where R is 2-, 3- or 4-heptyl or 4- (4-prop1) heptyl;
Rg - атом хлора или -O-C-R -группа , в которой R имеет указанные значе. ни ;Rg is a chlorine atom or a —O — C — R group in which R has the indicated meanings. neither;
с образованием моно- или дизамещенного производного общей формулы 1 в выСоставитель Г.Архипова Редактор О.Куанецова Техред И.Карандашова Корректор ИЛозн ковска with the formation of a mono- or disubstituted derivative of general formula 1 as a compiler of G. Arkhipov Editor O. Kuanetsova Tehred I. Karandashova Proofreader
Заказ оШ1Изд. J |)П Тираж 29ПодписвоеOrder OUT J |) P Circulation 29Subscription
ЦНИИПИ Государственного комитета (Зовета Министров СССР по делам изобретений и открытий Москва, 113035, Раушска наб., 4TSNIIPI State Committee (of the USSR Council of Ministers for Inventions and Discoveries Moscow, 113035, Raushsk nab., 4
Предпри тие «Патеит, Москва, Г-59, Бережковска наб., 24Enterprise “Pateit, Moscow, G-59, Berezhkovsk nab. 24
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3437872A GB1384150A (en) | 1972-07-21 | 1972-07-21 | Pyrimidine derivatives and process for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU468422A3 true SU468422A3 (en) | 1975-04-25 |
Family
ID=10364909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1939807A SU468422A3 (en) | 1972-07-21 | 1973-07-20 | The method of producing pyrimidine derivatives |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4980082A (en) |
| AR (1) | AR197241A1 (en) |
| AT (1) | AT326671B (en) |
| AU (1) | AU470607B2 (en) |
| BE (1) | BE802451A (en) |
| CA (1) | CA986518A (en) |
| CH (1) | CH579552A5 (en) |
| DE (1) | DE2336678A1 (en) |
| DK (1) | DK131626C (en) |
| ES (1) | ES417142A1 (en) |
| FR (1) | FR2193604B1 (en) |
| GB (1) | GB1384150A (en) |
| HU (1) | HU167313B (en) |
| IE (1) | IE38033B1 (en) |
| NL (1) | NL7309988A (en) |
| NO (1) | NO137691C (en) |
| OA (1) | OA04539A (en) |
| SE (1) | SE399556B (en) |
| SU (1) | SU468422A3 (en) |
| YU (1) | YU180673A (en) |
| ZA (1) | ZA734406B (en) |
-
1972
- 1972-07-21 GB GB3437872A patent/GB1384150A/en not_active Expired
-
1973
- 1973-06-28 ZA ZA734406A patent/ZA734406B/en unknown
- 1973-06-29 AR AR248838A patent/AR197241A1/en active
- 1973-06-29 IE IE1093/73A patent/IE38033B1/en unknown
- 1973-07-02 YU YU01806/73A patent/YU180673A/en unknown
- 1973-07-04 AU AU57699/73A patent/AU470607B2/en not_active Expired
- 1973-07-05 AT AT591673A patent/AT326671B/en not_active IP Right Cessation
- 1973-07-17 BE BE133575A patent/BE802451A/en unknown
- 1973-07-18 NL NL7309988A patent/NL7309988A/xx unknown
- 1973-07-19 SE SE7310102A patent/SE399556B/en unknown
- 1973-07-19 DE DE19732336678 patent/DE2336678A1/en active Pending
- 1973-07-20 OA OA54970A patent/OA04539A/en unknown
- 1973-07-20 DK DK404273A patent/DK131626C/en active
- 1973-07-20 FR FR7326645A patent/FR2193604B1/fr not_active Expired
- 1973-07-20 CH CH1066673A patent/CH579552A5/xx not_active IP Right Cessation
- 1973-07-20 HU HULA829A patent/HU167313B/hu unknown
- 1973-07-20 SU SU1939807A patent/SU468422A3/en active
- 1973-07-20 CA CA176990A patent/CA986518A/en not_active Expired
- 1973-07-20 NO NO2951/73A patent/NO137691C/en unknown
- 1973-07-21 ES ES417142A patent/ES417142A1/en not_active Expired
- 1973-07-21 JP JP48082371A patent/JPS4980082A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH579552A5 (en) | 1976-09-15 |
| DE2336678A1 (en) | 1974-01-31 |
| HU167313B (en) | 1975-09-27 |
| IE38033L (en) | 1974-01-21 |
| AU5769973A (en) | 1975-01-09 |
| AT326671B (en) | 1975-12-29 |
| OA04539A (en) | 1980-03-30 |
| IE38033B1 (en) | 1977-12-07 |
| SE399556B (en) | 1978-02-20 |
| CA986518A (en) | 1976-03-30 |
| BE802451A (en) | 1974-01-17 |
| FR2193604A1 (en) | 1974-02-22 |
| ATA591673A (en) | 1975-03-15 |
| NL7309988A (en) | 1974-01-23 |
| ES417142A1 (en) | 1976-03-01 |
| JPS4980082A (en) | 1974-08-02 |
| FR2193604B1 (en) | 1977-01-28 |
| ZA734406B (en) | 1974-06-26 |
| DK131626C (en) | 1976-01-19 |
| GB1384150A (en) | 1975-02-19 |
| AR197241A1 (en) | 1974-03-22 |
| YU180673A (en) | 1980-04-30 |
| AU470607B2 (en) | 1976-03-25 |
| NO137691B (en) | 1977-12-27 |
| NO137691C (en) | 1978-04-05 |
| DK131626B (en) | 1975-08-11 |
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