SU1678209A3 - Способ получени производных диазепинона или их физиологически переносимых солей - Google Patents

Способ получени производных диазепинона или их физиологически переносимых солей Download PDF

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Publication number
SU1678209A3
SU1678209A3 SU894614119A SU4614119A SU1678209A3 SU 1678209 A3 SU1678209 A3 SU 1678209A3 SU 894614119 A SU894614119 A SU 894614119A SU 4614119 A SU4614119 A SU 4614119A SU 1678209 A3 SU1678209 A3 SU 1678209A3
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USSR - Soviet Union
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hydrogen
image
radicals
lower alkyl
methyl
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SU894614119A
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English (en)
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Мим Герхард
Эберлейн Вольфганг
Энгель Вольфгард
Труммлитц Гюнтер
Майер Норберт
Де Ионге Андриаан
Доодс Хенри
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Др.Карл Томэ Гмбх (Фирма)
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Publication of SU1678209A3 publication Critical patent/SU1678209A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относитс  к гетероциклическим соединени м, в частности к получению производных диазепинона ф-лы О 0 C-CH2-N(Ri)-CH2-CH2 ,-0 Ґ СН3 где RI - СНз, этил; R2 - Н или Cf, X-CH или N, или их физиологически переносимых солей, обладающих селективным антимускарино- вым действием. Цель - разработка способа получени  более активных соединений. Получение ведут реакцией соответствующего N-хлорацетилпроизводного с 1-метил-2- 2-{метил- или этиламино) этил пирролидоном с последующим выделением целевого продукта в свободном виде или в виде физиологически переносимой соли. 3 табл. (Л TTBliMH

Description

Таблица 2

Claims (1)

  1. Формула изобретения
    Способ получения производных диазепинона общей формулы 20 где Ri - метил, этил;
    R2 - водород или хлор : X - группа СН или азот, или их физиологически переносимых солей, отличающийся тем, что соединение общей формулы
    0 П
    О=с-сн2-на1 где R'z имеет указанные значения,
    На I - галоид, подвергают взаимодействию с соединением общей формулы
    RrNHCH2CH2 -О сн3 где Ri имеет указанные значения, с последующим выделением целевого продукта в свободном виде или в виде физиологически переносимой соли.
    Таблица!
    I Соединение примера КТ5о/нМ’1 Кортекс Сердце Нижняя челюсть 1 50 9 80 4 70 10 100 2 8 3 20 Пирензепин 100 1500 200
    Таблица 2
    Соединение примера 1одЭД5о/моль кг’1 Сердце Кровяное давление Саливация 1 7,91 7,06 6,8 Пирензепин 5,60 6,94 6,22
    Таблица 3
    Соединение примера log ЭДбо/моль кг’1 Сердце Бронхии Мочевой пузырь 1 7,7 7,6 6,85 4 7,0 6,72 6,08 2 7,54 7,53 6,63 Пирензепин 5,85 6,57 5,36
SU894614119A 1988-06-15 1989-05-24 Способ получени производных диазепинона или их физиологически переносимых солей SU1678209A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3820346A DE3820346A1 (de) 1988-06-15 1988-06-15 Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
SU1678209A3 true SU1678209A3 (ru) 1991-09-15

Family

ID=6356594

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894614119A SU1678209A3 (ru) 1988-06-15 1989-05-24 Способ получени производных диазепинона или их физиологически переносимых солей

Country Status (16)

Country Link
US (1) US5002943A (ru)
EP (1) EP0346745A1 (ru)
JP (1) JPH0240381A (ru)
KR (1) KR900000365A (ru)
AU (1) AU612493B2 (ru)
DD (1) DD284016A5 (ru)
DE (1) DE3820346A1 (ru)
DK (1) DK291189A (ru)
FI (1) FI892897A (ru)
HU (1) HU201759B (ru)
IL (1) IL90590A0 (ru)
NO (1) NO168477C (ru)
PH (1) PH27213A (ru)
PT (1) PT90842A (ru)
SU (1) SU1678209A3 (ru)
ZA (1) ZA894461B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818299A1 (de) * 1988-05-30 1989-12-07 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE103918T1 (de) * 1989-06-28 1994-04-15 Boehringer Ingelheim Pharma 5,11-dihydro-6h-dipyrido(3,2-b:2',3'e>(1,4>diazepin-6-one und -thione und ihre verwendung bei der aids-vorbeugung oder behandlung.
US5179090A (en) * 1989-09-11 1993-01-12 Klaus Rudolf Condensed diazepinones and medicaments containing these compounds
US5418229A (en) * 1990-01-06 1995-05-23 Alker; David Muscarinic receptor antagonists
WO1996013488A1 (fr) * 1994-10-31 1996-05-09 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive de benzodiazepinone et composition medicinale constituee de celui-ci
IL131685A (en) * 1999-09-01 2007-03-08 Mordechai Erez Antiarrhythmic, antifbirillatory, and defibrillatory pharmaceutical compositions containing dibenzoazepines and dibenzodiazepines and same such novel compounds
RU2543320C2 (ru) * 2013-04-01 2015-02-27 Федеральное государственное бюджетное учреждение науки Институт физиологии Коми научного центра Уральского отделения Российской академии наук Применение 2-морфолино-5-фенил-6н-1,3,4-тиадизин, гидробромида в качестве средства, изменяющего суммарную мощность спектра вариабельности сердечного ритма и обладающего антибрадикардическими свойствами

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210648A (en) * 1977-05-31 1980-07-01 Boehringer Ingelheim Gmbh II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and salts thereof
US4311700A (en) * 1979-08-10 1982-01-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrimidobenzodiazepinones, their use and medicaments containing them
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
DE3262922D1 (en) * 1981-02-02 1985-05-15 Byk Gulden Lomberg Chem Fab Tricyclic pyrrols, process for their preparation, their use and compositions containing them
ATE71097T1 (de) * 1985-06-27 1992-01-15 Thomae Gmbh Dr K In 11-stellung substituierte 5,11-dihydro-6hpyrido-(2,3-b>(1,4>benzodiazepin-6-one, verfahren zur ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3626095A1 (de) * 1986-07-31 1988-02-11 Thomae Gmbh Dr K Neue substituierte pyrido(2,3-b)(1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT8721978A0 (it) * 1987-09-21 1987-09-21 Angeli Inst Spa Nuovi derivati ammidinici triciclici.
US4931436A (en) * 1988-08-09 1990-06-05 Dr. Karl Thomae Gmbh Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент GB № 1483325, кл. С 07 D 487/04, 1977. Патент US № 3660380, кл.260-23973, 1973. Патент DE №2644121, кл. С 07 D 471/04, 1978. За вка JP № 62-16952-, кл. С 07 D 471/04, 1987. *

Also Published As

Publication number Publication date
ZA894461B (en) 1991-02-27
DK291189A (da) 1989-12-16
FI892897A0 (fi) 1989-06-14
US5002943A (en) 1991-03-26
NO168477C (no) 1992-02-26
DD284016A5 (de) 1990-10-31
AU612493B2 (en) 1991-07-11
DK291189D0 (da) 1989-06-14
PT90842A (pt) 1989-12-29
NO892432L (no) 1989-12-18
JPH0240381A (ja) 1990-02-09
HU201759B (en) 1990-12-28
NO168477B (no) 1991-11-18
EP0346745A1 (de) 1989-12-20
FI892897A (fi) 1989-12-16
KR900000365A (ko) 1990-01-30
DE3820346A1 (de) 1989-12-21
AU3644689A (en) 1989-12-21
PH27213A (en) 1993-05-04
NO892432D0 (no) 1989-06-13
IL90590A0 (en) 1990-01-18
HUT50472A (en) 1990-02-28

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