SU1660573A3 - Способ получени концентрата гема - Google Patents
Способ получени концентрата гема Download PDFInfo
- Publication number
- SU1660573A3 SU1660573A3 SU813359217A SU3359217A SU1660573A3 SU 1660573 A3 SU1660573 A3 SU 1660573A3 SU 813359217 A SU813359217 A SU 813359217A SU 3359217 A SU3359217 A SU 3359217A SU 1660573 A3 SU1660573 A3 SU 1660573A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- volume
- ethanol
- mixture
- content
- heme
- Prior art date
Links
- 239000012141 concentrate Substances 0.000 title claims abstract description 33
- 150000003278 haem Chemical class 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 189
- 239000000203 mixture Substances 0.000 claims abstract description 81
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract description 72
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 8
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 4
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 4
- 102000018146 globin Human genes 0.000 claims abstract description 4
- 108060003196 globin Proteins 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims abstract description 3
- 208000007502 anemia Diseases 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 239000012024 dehydrating agents Substances 0.000 claims abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 150000003841 chloride salts Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 abstract description 14
- 239000008280 blood Substances 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 7
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 57
- 239000007858 starting material Substances 0.000 description 42
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 20
- 239000000243 solution Substances 0.000 description 17
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 239000006228 supernatant Substances 0.000 description 14
- 238000003756 stirring Methods 0.000 description 13
- 238000001816 cooling Methods 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 11
- 239000004471 Glycine Substances 0.000 description 10
- 238000000605 extraction Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 239000005457 ice water Substances 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- UXHQLGLGLZKHTC-CUNXSJBXSA-N 4-[(3s,3ar)-3-cyclopentyl-7-(4-hydroxypiperidine-1-carbonyl)-3,3a,4,5-tetrahydropyrazolo[3,4-f]quinolin-2-yl]-2-chlorobenzonitrile Chemical compound C1CC(O)CCN1C(=O)C1=CC=C(C=2[C@@H]([C@H](C3CCCC3)N(N=2)C=2C=C(Cl)C(C#N)=CC=2)CC2)C2=N1 UXHQLGLGLZKHTC-CUNXSJBXSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/017—Hydrolysed proteins; Derivatives thereof from animals from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002591A SE440596B (sv) | 1980-04-03 | 1980-04-03 | Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1660573A3 true SU1660573A3 (ru) | 1991-06-30 |
Family
ID=20340685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU813359217A SU1660573A3 (ru) | 1980-04-03 | 1981-11-30 | Способ получени концентрата гема |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4431581A (enExample) |
| EP (1) | EP0056025B1 (enExample) |
| JP (1) | JPH0134204B2 (enExample) |
| DK (1) | DK154266C (enExample) |
| IE (1) | IE51040B1 (enExample) |
| IN (1) | IN152639B (enExample) |
| SE (1) | SE440596B (enExample) |
| SU (1) | SU1660573A3 (enExample) |
| WO (1) | WO1981002834A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2604190C2 (ru) * | 2012-03-09 | 2016-12-10 | Шанхай Дженон Байолоджикал Продакт Ко., Лтд | Способ получения малозольного порошка белка птичьей плазмы с использованием птичьей крови |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2548671B1 (fr) * | 1983-07-07 | 1986-05-02 | Merieux Inst | Procede de preparation de globine a partir d'hemoglobine et globine obtenue par ce procede |
| FI68970C (fi) * | 1983-08-10 | 1985-12-10 | Medica Pharma Co Ltd | Foerfarande foer framstaellning av en ny medicinskt anvaendbarhemin-foerening |
| US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
| FR2714380B1 (fr) * | 1993-12-24 | 1996-05-24 | Bioxytech | Utilisation de dérivés 2-mercapto-imidazole substitués en position 4 (ou 5) comme agents antioxydants, leur procédé de préparation et leurs applications en pharmacie, cosmétique ou alimentaire. |
| WO1998028302A1 (de) * | 1996-12-20 | 1998-07-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur gewinnung von hämin aus schlachtblut |
| US6845820B1 (en) * | 2000-10-19 | 2005-01-25 | Weatherford/Lamb, Inc. | Completion apparatus and methods for use in hydrocarbon wells |
| US6749872B2 (en) * | 2002-02-01 | 2004-06-15 | The Lauridsen Group Incorporated | Heme supplement and method of using same |
| CN103536670A (zh) * | 2013-10-17 | 2014-01-29 | 新疆天海绿洲农业科技股份有限公司 | 一种改善营养性贫血的组合物及其制备方法 |
| CN103610828B (zh) * | 2013-12-10 | 2015-10-28 | 王怀兰 | 治疗女性贫血中药组合物及制备方法 |
| KR20180079846A (ko) | 2017-01-03 | 2018-07-11 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 생물학적 방법 |
| KR101894575B1 (ko) | 2017-01-03 | 2018-09-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법 |
| WO2023101604A2 (en) * | 2021-11-30 | 2023-06-08 | National University Of Singapore | Heme, compositions and method of synthesis thereof |
| WO2025171162A1 (en) * | 2024-02-06 | 2025-08-14 | Colorado Biolabs, Inc. | Process for production of heme iron |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU492555B1 (en) * | 1974-01-08 | 1976-07-08 | Commonwealth Scientific And Industrial Research Organization | Separation of protein from blood |
| AU7715575A (en) * | 1974-01-08 | 1976-07-08 | Commw Scient Ind Res Org | Separation of protein from blood |
| SE389596B (sv) * | 1974-06-14 | 1976-11-15 | P G S Lindroos | Saett att ur en vaetska innehallande blodsubstanser separera jaernfoereningar fran globin |
| SE7513987L (sv) * | 1975-12-11 | 1977-06-12 | Paul Goran Sigvard Lindroos | Sett att behandla vetskor innehallande blodsubstanser |
| US4098780A (en) * | 1975-06-04 | 1978-07-04 | Paul Goran Sigvard Lindroos | Method of treating liquids containing blood substances |
| CA1126653A (en) * | 1978-12-22 | 1982-06-29 | Jan H. Luijerink | Process of preparing blood cell protein and heme from hemoglobin |
-
1980
- 1980-04-03 SE SE8002591A patent/SE440596B/sv not_active IP Right Cessation
-
1981
- 1981-03-24 IE IE644/81A patent/IE51040B1/en unknown
- 1981-04-01 WO PCT/FI1981/000026 patent/WO1981002834A1/en not_active Ceased
- 1981-04-01 US US06/324,395 patent/US4431581A/en not_active Expired - Fee Related
- 1981-04-01 EP EP81900824A patent/EP0056025B1/en not_active Expired
- 1981-04-01 JP JP56501036A patent/JPH0134204B2/ja not_active Expired
- 1981-04-02 IN IN371/CAL/81A patent/IN152639B/en unknown
- 1981-11-30 SU SU813359217A patent/SU1660573A3/ru active
- 1981-11-30 DK DK530181A patent/DK154266C/da not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Патент DE №2656157, кл. С07 G 7/00, 1977. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2604190C2 (ru) * | 2012-03-09 | 2016-12-10 | Шанхай Дженон Байолоджикал Продакт Ко., Лтд | Способ получения малозольного порошка белка птичьей плазмы с использованием птичьей крови |
Also Published As
| Publication number | Publication date |
|---|---|
| DK154266B (da) | 1988-10-31 |
| SE440596B (sv) | 1985-08-12 |
| US4431581A (en) | 1984-02-14 |
| IE51040B1 (en) | 1986-09-17 |
| EP0056025B1 (en) | 1985-10-09 |
| IN152639B (enExample) | 1984-02-25 |
| DK154266C (da) | 1989-03-28 |
| WO1981002834A1 (en) | 1981-10-15 |
| DK530181A (da) | 1981-11-30 |
| IE810644L (en) | 1981-10-03 |
| JPH0134204B2 (enExample) | 1989-07-18 |
| JPS57500431A (enExample) | 1982-03-11 |
| SE8002591L (sv) | 1981-10-04 |
| EP0056025A1 (en) | 1982-07-21 |
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