SU1428178A3 - Композици защитной оболочки дл биологически активных веществ - Google Patents
Композици защитной оболочки дл биологически активных веществ Download PDFInfo
- Publication number
- SU1428178A3 SU1428178A3 SU823501204A SU3501204A SU1428178A3 SU 1428178 A3 SU1428178 A3 SU 1428178A3 SU 823501204 A SU823501204 A SU 823501204A SU 3501204 A SU3501204 A SU 3501204A SU 1428178 A3 SU1428178 A3 SU 1428178A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- vinyl
- styrene
- pyridine
- methyl
- copolymer
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 8
- 230000001681 protective effect Effects 0.000 title description 20
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 229930182817 methionine Natural products 0.000 claims description 32
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 31
- 229920001577 copolymer Polymers 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 18
- 229920002678 cellulose Polymers 0.000 claims description 16
- 239000001913 cellulose Substances 0.000 claims description 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 239000008280 blood Substances 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 239000011253 protective coating Substances 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 210000000090 ruminant stomach Anatomy 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 108700022128 Hypermethioninemia Proteins 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 abstract description 2
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 239000012798 spherical particle Substances 0.000 description 5
- 206010016717 Fistula Diseases 0.000 description 3
- 241000282849 Ruminantia Species 0.000 description 3
- 230000003890 fistula Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229920006163 vinyl copolymer Polymers 0.000 description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-N benzene-dicarboxylic acid Natural products OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 229960002380 dibutyl phthalate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8118954A FR2514261B1 (fr) | 1981-10-08 | 1981-10-08 | Nouvelle composition pour l'enrobage des aliments et des medicaments et granules ainsi enrobes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1428178A3 true SU1428178A3 (ru) | 1988-09-30 |
Family
ID=9262851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU823501204A SU1428178A3 (ru) | 1981-10-08 | 1982-10-06 | Композици защитной оболочки дл биологически активных веществ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4675175A (enExample) |
| EP (1) | EP0077264B1 (enExample) |
| JP (1) | JPS5872516A (enExample) |
| AT (1) | ATE33097T1 (enExample) |
| AU (1) | AU557929B2 (enExample) |
| BR (1) | BR8205913A (enExample) |
| DE (1) | DE3278263D1 (enExample) |
| ES (1) | ES516375A0 (enExample) |
| FR (1) | FR2514261B1 (enExample) |
| NZ (1) | NZ202095A (enExample) |
| SU (1) | SU1428178A3 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2125445C1 (ru) * | 1992-09-03 | 1999-01-27 | Жансен Фармасетика Н.В. | Гранула, способ ее получения и фармацевтическая композиция |
| RU2317065C1 (ru) * | 2006-12-05 | 2008-02-20 | Владимир Андрианович Алешкин | Способ определения целевой доставки в желудочно-кишечном тракте твердой лекарственной формы с защитным покрытием |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR8506634A (pt) * | 1984-12-20 | 1986-09-09 | Rhone Poulenc Sante | Composicoes para o revestimento de aditivos alimentares destinados aos ruminantes e granulados sob forma de microcapsulas assim revestidos |
| FR2575039B1 (fr) * | 1984-12-20 | 1990-01-19 | Aec Chim Organ Biolog | Compositions pour l'enrobage des additifs alimentaires destines aux ruminants et additifs alimentaires ainsi enrobes |
| FR2575040B1 (fr) * | 1984-12-20 | 1990-02-09 | Rhone Poulenc Sante | Nouvelles compositions pour l'enrobage des additifs alimentaires destines aux ruminants et additifs alimentaires ainsi enrobes |
| US5186937A (en) * | 1985-06-07 | 1993-02-16 | A.E.C. Societe De Chimie Organique Et Biologique | Composition for feeding ruminants |
| FR2582909B1 (fr) * | 1985-06-07 | 1991-05-10 | Aec Chim Organ Biolog | Produit pour l'alimentation des ruminants et sa preparation. |
| US4717567A (en) * | 1985-11-25 | 1988-01-05 | Eastman Kodak Company | Rumen-stable pellets |
| US4780315A (en) * | 1985-11-25 | 1988-10-25 | Eastman Kodak Company | Rumen-stable pellets |
| FR2603458B1 (fr) * | 1986-09-04 | 1990-11-02 | Rhone Poulenc Sante | Nouvelles compositions pour l'enrobage des additifs alimentaires destines aux ruminants et additifs alimentaires ainsi enrobes |
| US5612059A (en) * | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
| CA1331713C (en) * | 1988-12-29 | 1994-08-30 | Hitoshi Iijima | Granular composition for ruminant |
| FR2648020B1 (fr) * | 1989-06-12 | 1992-03-13 | Rhone Poulenc Sante | Utilisation de compositions degradables par voie enzymatique pour l'enrobage d'additifs alimentaires destines aux ruminants |
| US5225218A (en) * | 1989-10-10 | 1993-07-06 | Rhone-Poulenc Nutrition Animale | Method of making cheese with milk obtained from animals fed with a feed supplemented with an amino acid |
| IT1246383B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per il mascheramento del sapore di farmaci |
| FR2663207B1 (fr) * | 1990-06-15 | 1993-04-30 | Rhone Poulenc Nutrition Animal | Procede d'enrobage par un polymere ph sensible de principes actifs. |
| ATE118345T1 (de) * | 1990-08-07 | 1995-03-15 | Pfizer | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
| CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
| CN1107288A (zh) * | 1993-03-04 | 1995-08-30 | 罗纳-普朗克动物营养素公司 | 提高生育期雌羊羊毛产量和质量的方法 |
| US5788687A (en) * | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| US20050106250A1 (en) | 2002-05-10 | 2005-05-19 | Hasseberg Hans A. | Protected active compound formulations of amino acids and process for their preparation |
| EP1694303A1 (en) * | 2003-12-15 | 2006-08-30 | Council Of Scientific And Industrial Research | Taste masked pharmaceutical composition comprising ph sensitive polymer |
| WO2005055987A1 (en) * | 2003-12-15 | 2005-06-23 | Council Of Scientific & Industrial Research | TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER |
| CN100491423C (zh) * | 2003-12-15 | 2009-05-27 | 科学与工业研究委员会 | pH敏感性聚合物及其制备方法 |
| AU2004325469B2 (en) * | 2004-12-10 | 2009-02-05 | Council Of Scientific And Industrial Research | Pharmaceutical composition for improving palatability of drugs and process for preparation thereof |
| JPWO2008053810A1 (ja) * | 2006-10-30 | 2010-02-25 | 三井化学株式会社 | pH応答性ゲルおよびその製造方法、ならびにpH応答性バルブ |
| EP3375453A1 (de) | 2017-03-13 | 2018-09-19 | Basf Se | Verwendung einer pansengeschützen alpha-amylase |
| CN108102938B (zh) * | 2017-12-19 | 2021-02-19 | 北京化工大学 | 一种基于药物缓、控释的载药微球防控生物乙醇发酵染菌的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL262837A (enExample) * | 1960-03-28 | |||
| US3562806A (en) * | 1968-09-10 | 1971-02-09 | Eastman Kodak Co | Rumen stable medicament and/or nutrient compositions |
| US3978204A (en) * | 1969-02-04 | 1976-08-31 | L'oreal | Cosmetic composition containing microencapsulated solvents for nail enamel |
| GB1357737A (en) * | 1970-10-09 | 1974-06-26 | Arpic Sa | Sustained release pharmaceutical compositions |
| EG10802A (en) * | 1971-02-19 | 1976-10-31 | Bayer Ag | A process for embeding veterinary substances and their protection against the influence of the gastric juice of the rumen |
| US4196187A (en) * | 1977-09-02 | 1980-04-01 | Eastman Kodak Company | Rumen-stable pellets |
| US4177255A (en) * | 1977-09-02 | 1979-12-04 | Eastman Kodak Company | Rumen-stable pellets |
| FR2401619A1 (fr) * | 1977-09-02 | 1979-03-30 | Eastman Kodak Co | Procede pour preparer des granules indegradables dans la panse des ruminants |
| US4181709A (en) * | 1977-09-02 | 1980-01-01 | Eastman Kodak Company | Rumen-stable pellets |
-
1981
- 1981-10-08 FR FR8118954A patent/FR2514261B1/fr not_active Expired
-
1982
- 1982-10-06 DE DE8282401838T patent/DE3278263D1/de not_active Expired
- 1982-10-06 NZ NZ202095A patent/NZ202095A/en unknown
- 1982-10-06 JP JP57176021A patent/JPS5872516A/ja active Granted
- 1982-10-06 AT AT82401838T patent/ATE33097T1/de not_active IP Right Cessation
- 1982-10-06 SU SU823501204A patent/SU1428178A3/ru active
- 1982-10-06 AU AU89165/82A patent/AU557929B2/en not_active Ceased
- 1982-10-06 EP EP82401838A patent/EP0077264B1/fr not_active Expired
- 1982-10-07 BR BR8205913A patent/BR8205913A/pt unknown
- 1982-10-08 ES ES516375A patent/ES516375A0/es active Granted
-
1984
- 1984-08-07 US US06/638,539 patent/US4675175A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Авторское свидетельство СССР 181902, кл. А 23 К 1/18, 1965. Патент FR № 2401620, кл. А 23 К 1/18, 1979. k . * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2125445C1 (ru) * | 1992-09-03 | 1999-01-27 | Жансен Фармасетика Н.В. | Гранула, способ ее получения и фармацевтическая композиция |
| RU2317065C1 (ru) * | 2006-12-05 | 2008-02-20 | Владимир Андрианович Алешкин | Способ определения целевой доставки в желудочно-кишечном тракте твердой лекарственной формы с защитным покрытием |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ202095A (en) | 1986-05-09 |
| JPH057376B2 (enExample) | 1993-01-28 |
| FR2514261B1 (fr) | 1986-08-22 |
| JPS5872516A (ja) | 1983-04-30 |
| ES8402720A1 (es) | 1984-02-16 |
| ATE33097T1 (de) | 1988-04-15 |
| ES516375A0 (es) | 1984-02-16 |
| AU8916582A (en) | 1983-04-14 |
| US4675175A (en) | 1987-06-23 |
| AU557929B2 (en) | 1987-01-15 |
| EP0077264A1 (fr) | 1983-04-20 |
| DE3278263D1 (en) | 1988-04-28 |
| EP0077264B1 (fr) | 1988-03-23 |
| FR2514261A1 (fr) | 1983-04-15 |
| BR8205913A (pt) | 1983-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU1428178A3 (ru) | Композици защитной оболочки дл биологически активных веществ | |
| US4837004A (en) | Rumen-stable pellets | |
| US4876097A (en) | Compositions for coating feeding stuff additives intended for ruminants and feeding stuff additives thus coated | |
| CA1293194C (en) | Medicine based on fenofibrate, and a method of preparing it | |
| JP2662253B2 (ja) | 生物活性剤の制御された放出のための逆相形態を有するポリマーブレンド | |
| US5186937A (en) | Composition for feeding ruminants | |
| US5098718A (en) | Enzymatically degradable coating compositions for feed additives intended for ruminants | |
| US4877621A (en) | Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated | |
| EP0246310B1 (en) | Rumen-stable pellets | |
| US5087455A (en) | Hollow granular medicine and its preparation | |
| KR100192154B1 (ko) | Ph-민감성 중합체로 활성 성분을 코우팅하는 방법 | |
| CA1240267A (en) | Rumen-stable pellets | |
| US5225238A (en) | Method for coating active principles with a ph-sensitive polymer | |
| US4153682A (en) | Compositions for controlled availability of medically useful organophosphorus compounds | |
| CA1283497C (en) | Polymer-treated ion exchange resins | |
| RU1816212C (ru) | Способ нанесени покрыти на действующее начало | |
| JP2848882B2 (ja) | 高吸水性樹脂の製造法 | |
| SU1605911A3 (ru) | Корм дл жвачных животных | |
| AU627444B2 (en) | Rumen-stable pellets | |
| CS251786B2 (en) | Method of pharmaceutical preparations production with depot effect | |
| EP0557064A1 (en) | Modified release formulation | |
| SU789069A1 (ru) | Способ получени гранулированных комбикормов дл рыб |