SU1397786A1 - Method of quantitative determination of 5-ethyl-5-isoamylbarbiturate of sodium - Google Patents
Method of quantitative determination of 5-ethyl-5-isoamylbarbiturate of sodium Download PDFInfo
- Publication number
- SU1397786A1 SU1397786A1 SU864162585A SU4162585A SU1397786A1 SU 1397786 A1 SU1397786 A1 SU 1397786A1 SU 864162585 A SU864162585 A SU 864162585A SU 4162585 A SU4162585 A SU 4162585A SU 1397786 A1 SU1397786 A1 SU 1397786A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sodium
- ethyl
- quantitative determination
- sensitivity
- isoamylbarbiturate
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 9
- 229910052708 sodium Inorganic materials 0.000 title claims description 7
- 239000011734 sodium Substances 0.000 title claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title claims description 5
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 title description 3
- 230000035945 sensitivity Effects 0.000 claims abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract 3
- 229940125717 barbiturate Drugs 0.000 claims description 2
- 238000005375 photometry Methods 0.000 claims 1
- -1 sulfonyl-2-chloro-1,4-naphthoquinone Chemical compound 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract description 3
- 230000000147 hypnotic effect Effects 0.000 abstract description 2
- MHQHHBYRYFICDV-UHFFFAOYSA-M sodium;pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].O=C1CC(=O)[N-]C(=O)N1 MHQHHBYRYFICDV-UHFFFAOYSA-M 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Изобретение касаетс аналитической химии, в частности определени 5-этш1-5-изоамш1барбитурата натри (АБН), примен емого в качестве снотворного средства в медицине. Дл по- вьипени чувствительности и упрощени процесса пробу обрабатывают другим реагентом-Ы-толуолсульфонил-2-хлор- 1,4-нафтохинонимином в среде диокса- на. Затем окрашенньш раствор фотомет- рируют. Чувствительность способа 0,019-0,35 мг/мл при меньшем в 4 раза времени (15 мин) анализа без нёобг ходимости предварительной очистки растворител . 2 табл. |СЛThe invention relates to analytical chemistry, in particular, the determination of 5-eth1-5-isoamosil sodium barbiturate (ABN), used as a hypnotic in medicine. In order to increase sensitivity and simplify the process, the sample is treated with another L-toluenesulfonyl-2-chloro-1,4-naphthoquinone imine reagent in dioxane medium. Then the colored solution is photometrized. The sensitivity of the method is 0.019–0.35 mg / ml with a 4 times less time (15 min) analysis without the need for preliminary purification of the solvent. 2 tab. | SL
Description
00 со 00 with
0000
э:uh:
Изобретение относитс к аналитической химии, а именно к способам количественного определани 5-этил- 5-изоамилбарблтурата натри (барбами ла), примен емого в медицинской практике в качестве снотворного средстваThe invention relates to analytical chemistry, and specifically to methods for the quantitative determination of 5-ethyl-5-isoamyl barburt sodium (barbamyl), used in medical practice as a hypnotic.
Цель изобретени - повышение чувствительности и упрощение способа.The purpose of the invention is to increase the sensitivity and simplify the method.
П р и м е.р. Количественное опре- деление 5-этил-5-изоамилбарбитурата натри в субстанции. Точную навеску анализируемого вещества в пределах 10,012-0,022 г раствор ют в воде в мерной колбе вместимостью 50 мл и до |вод т водой до метки. 2 мл получен- JHoro разведени помещают в мерную колбу вместимостью 25 мл, прибавл ют 5 мл 0,5%-ного диоксанового раствора Н-толуолсульфонш1-2-хлор-1,4-наф- тохинонимина и через 10 мин довод т диоксаном до метки. Параллельно провод т опыт со стандартным раствором 5-этип-5-изоамш1барбитурата натри (0,015 г в 50 мп) и раствором-фоном. PRI m er.r. Quantitative determination of 5-ethyl-5-isoamyl barbiturate sodium in a substance. The exact weight of the analyte within 10,012-0,022 g is dissolved in water in a 50 ml volumetric flask and made up to the mark with water. 2 ml of the obtained JHoro dilution is placed in a 25 ml volumetric flask, 5 ml of a 0.5% dioxane solution of H-toluenesulfonic 1-2-chloro-1,4-naphthoquinone imine are added and, after 10 min, the dioxane is added to the mark . In parallel, experiments were carried out with a standard solution of 5-ethyl-5-iso-sodium sodium barbiturate (0.015 g in 50 mp) and a background solution.
Оптическую плотность анализируемых растворов измер ют на фоне контрол при помощи спектрофотометра при 85 им в кюветах с толщиной сло 1 смThe optical density of the analyzed solutions was measured on the background of the control using a spectrophotometer at 85 them in cuvettes with a layer thickness of 1 cm
Расчет количественного содержани барбамила 5-этил-5-изоамш1барбитурат натри провод т по формулеThe calculation of the amount of barbamyl 5-ethyl-5-isoamosil barbiturite sodium is carried out according to the formula
D-50-25-CC,D-50-25-CC,
БГГр г Г GHBY yr
где D - оптическа плотность анализируемого раствора; Dp - оптическа плотность станwhere D is the optical density of the solution being analyzed; Dp is the optical density of the mill
дартного раствора;dart solution;
; С - концентраци стандартного спектрофотометрируемого раствора (0,00272 г в 100 мл); р - навеска , г; 1 - толщина сло , см. Результаты количественного опреде- лени 5-этил-5-изоамилбарбитурата натри приведены в табл. 1.; C is the concentration of a standard spectrophotometric solution (0.00272 g in 100 ml); p - weight, g; 1 — thickness of the layer, see. Results of the quantitative determination of 5-ethyl-5-isoamyl sodium barbitrate are given in Table. one.
Т а б л и ц а 1Table 1
100,4 100,2100.4 100.2
.75 ,9507.75, 9507
Продолжение табл.1Continuation of table 1
Сравнительна характеристика известного и предлагаемого способов приведена в табл. 2.Comparative characteristics of the known and proposed methods are given in table. 2
Таблица2Table 2
1-41-4
0,019-0,0350,019-0,035
Врем Time
проведени hold
анализа,analysis,
мин 60min 60
Предварительна очисткаPre-cleaning
раствори- Свеже- телей перегнанный пиридинsolvent- fresh distilled pyridine
1515
Не требуетс Not required
Как видно из табл. 2, данный способ по величине чувствительности превосходит известный в 50-100 раз. Кроме того, он значительно проще в выполнении, так как не требует предварительной перегонки растворителей, многократного зкстрагировани , высушивани экстракта, а врем проведени анализа сокращаетс в 4 раза.As can be seen from the table. 2, this method exceeds the known sensitivity by 50–100 times in magnitude. In addition, it is much easier to perform, since it does not require pre-distillation of solvents, multiple extractions, drying the extract, and the analysis time is reduced by 4 times.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU864162585A SU1397786A1 (en) | 1986-12-16 | 1986-12-16 | Method of quantitative determination of 5-ethyl-5-isoamylbarbiturate of sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU864162585A SU1397786A1 (en) | 1986-12-16 | 1986-12-16 | Method of quantitative determination of 5-ethyl-5-isoamylbarbiturate of sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1397786A1 true SU1397786A1 (en) | 1988-06-15 |
Family
ID=21273343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU864162585A SU1397786A1 (en) | 1986-12-16 | 1986-12-16 | Method of quantitative determination of 5-ethyl-5-isoamylbarbiturate of sodium |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1397786A1 (en) |
-
1986
- 1986-12-16 SU SU864162585A patent/SU1397786A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Государственна фармакопе СССР. Медицина, 1968, 10 изд. с. 133. Крамаренко В.Ф., Попова В.И. Фотометри в фармацевтическом анализе. Киев , 1972, с. 74-75. * |
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