SU1253439A3 - Способ определени @ -глутамилтранспептидазы - Google Patents
Способ определени @ -глутамилтранспептидазы Download PDFInfo
- Publication number
- SU1253439A3 SU1253439A3 SU1974541A SU1974541A SU1253439A3 SU 1253439 A3 SU1253439 A3 SU 1253439A3 SU 1974541 A SU1974541 A SU 1974541A SU 1974541 A SU1974541 A SU 1974541A SU 1253439 A3 SU1253439 A3 SU 1253439A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- glutamyl
- determination
- anilide
- mmol
- sulfo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 14
- 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 title 1
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 title 1
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 6
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 210000002966 serum Anatomy 0.000 claims description 9
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 4
- 108010008488 Glycylglycine Proteins 0.000 claims description 2
- 229940043257 glycylglycine Drugs 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 7
- 102000004190 Enzymes Human genes 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 230000003287 optical effect Effects 0.000 abstract description 5
- 108090000279 Peptidyltransferases Proteins 0.000 abstract description 3
- 208000019423 liver disease Diseases 0.000 abstract description 2
- BKKWZCSSYWYNDS-JEDNCBNOSA-N 2-aminoacetic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCC(O)=O.NCCCC[C@H](N)C(O)=O BKKWZCSSYWYNDS-JEDNCBNOSA-N 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000000758 substrate Substances 0.000 description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 3
- QIWKCQDJZPRXNS-VIFPVBQESA-N (2s)-2-[(2-carboxybenzoyl)amino]pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)C1=CC=CC=C1C(O)=O QIWKCQDJZPRXNS-VIFPVBQESA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000424 optical density measurement Methods 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 1
- KZZWQCKYLNIOBT-UHFFFAOYSA-N 5-amino-2-nitrobenzoic acid Chemical compound NC1=CC=C([N+]([O-])=O)C(C(O)=O)=C1 KZZWQCKYLNIOBT-UHFFFAOYSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine hydrate Chemical compound O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722259512 DE2259512C3 (de) | 1972-12-05 | gamma-Glutamyl-4-nitranilid-3carbonsäure, deren Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung | |
| DE19732333798 DE2333798C3 (de) | 1973-07-03 | gamma-Glutamyl-4-nitranilid-3sulfonsäure, deren Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1253439A3 true SU1253439A3 (ru) | 1986-08-23 |
Family
ID=25764185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1974541A SU1253439A3 (ru) | 1972-12-05 | 1973-12-04 | Способ определени @ -глутамилтранспептидазы |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US3979447A (enExample) |
| JP (1) | JPS547781B2 (enExample) |
| AR (1) | AR199011A1 (enExample) |
| AT (1) | AT331994B (enExample) |
| BE (1) | BE808035A (enExample) |
| CA (1) | CA1000721A (enExample) |
| CH (1) | CH605670A5 (enExample) |
| DD (1) | DD109377A5 (enExample) |
| DK (1) | DK151232C (enExample) |
| FI (1) | FI59790C (enExample) |
| FR (1) | FR2208886B1 (enExample) |
| GB (1) | GB1397008A (enExample) |
| HU (1) | HU168735B (enExample) |
| IL (1) | IL43735A (enExample) |
| IT (1) | IT1012529B (enExample) |
| NL (1) | NL166463C (enExample) |
| SE (2) | SE404791B (enExample) |
| SU (1) | SU1253439A3 (enExample) |
| YU (1) | YU39232B (enExample) |
| ZA (1) | ZA739238B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS584560B2 (ja) * | 1976-06-01 | 1983-01-26 | 三共株式会社 | 鉄錯塩を用いた酵素活性測定法 |
| JPS52148030A (en) * | 1976-06-01 | 1977-12-08 | Sankyo Co Ltd | Gamma-l-glutamylanilides |
| US4167449A (en) * | 1976-07-29 | 1979-09-11 | American Hospital Supply Corporation | Composition and method for determining transferase and protease activity |
| JPS53147034A (en) * | 1977-05-30 | 1978-12-21 | Wako Pure Chem Ind Ltd | Gamma-glutamyl-p-aminoanilide derivatives and process for their preparation |
| CA1087075A (en) * | 1977-08-05 | 1980-10-07 | Robert J. Gargiulo | Composition and method for determining transferase and protease activity |
| JPS5569549A (en) * | 1978-11-16 | 1980-05-26 | Nitto Boseki Co Ltd | Novel substrate for determination of enzyme activity |
| US4425427A (en) | 1980-03-13 | 1984-01-10 | Vitafin N.V. | Simultaneous, kinetic, spectrophotometric analysis of blood serum for multiple components |
| US4511651A (en) * | 1982-07-30 | 1985-04-16 | American Monitor Corporation | Reagent composition and assay for the determination of γ-glutamyltransferase activity |
| US4567138A (en) * | 1982-08-30 | 1986-01-28 | Beckman Instruments, Inc. | Method for determining γ-glutamyltransferase activity and kits containing a novel substrate solution for use therein |
| US4751178A (en) * | 1985-09-26 | 1988-06-14 | Eastman Kodak Company | Substrates, compositions, elements and methods for the determination of gamma-glutamyltransferase |
| US4851572A (en) * | 1987-07-03 | 1989-07-25 | Wako Pure Chemical Industries, Ltd. | γ-L-glutamyl-4-nitroanilide derivatives and process for determining γ-GTP activity using the same |
| FR2644697B1 (fr) * | 1989-03-24 | 1992-05-15 | Poudres & Explosifs Ste Nale | Composes anesthesiques a duree d'action controlee et compositions pharmaceutiques les contenant |
| US5474906A (en) * | 1993-03-26 | 1995-12-12 | Eiken Kagaku Kabushiki Kaisha | Reagent for determining γ-glutamyl transpeptidase activity |
| CN103980309B (zh) | 2008-10-03 | 2016-04-06 | 味之素株式会社 | CaSR激动剂 |
| WO2011108724A1 (ja) | 2010-03-04 | 2011-09-09 | 味の素株式会社 | 糖尿病又は肥満症の予防又は治療剤 |
| PT2546231T (pt) | 2010-03-04 | 2019-02-06 | Ea Pharma Co Ltd | Derivado de alquilamina |
| CN113045446A (zh) * | 2021-03-29 | 2021-06-29 | 合肥金锦生物科技有限公司 | 一种转肽酶生化检验试剂底物的制备方法 |
| CN117430521B (zh) * | 2023-09-05 | 2025-08-08 | 安徽立诺威智能科技有限公司 | 一种L-γ-谷氨酰基-3-羧基-4-硝基苯胺铵盐的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2951090A (en) * | 1958-04-17 | 1960-08-30 | Ogilvie Flour Mills Co Ltd | Preparation of dl-glutamine |
| AT293368B (de) * | 1969-10-13 | 1971-10-11 | Rotta Research Lab | Verfahren zur Herstellung von N-Benzoyl-L-(D- oder DL)-glutaminsäure-l-amiden |
| US3803223A (en) * | 1970-07-20 | 1974-04-09 | Searle & Co | 3-amino-n-substituted succinamic acids and intermediates thereto |
-
1973
- 1973-10-29 AT AT910973A patent/AT331994B/de not_active IP Right Cessation
- 1973-11-13 IT IT31264/73A patent/IT1012529B/it active
- 1973-11-15 NL NL7315657.A patent/NL166463C/xx not_active IP Right Cessation
- 1973-11-26 CA CA186,729A patent/CA1000721A/en not_active Expired
- 1973-11-27 US US05/419,455 patent/US3979447A/en not_active Expired - Lifetime
- 1973-11-28 FI FI3670/73A patent/FI59790C/fi active
- 1973-11-28 DK DK642273A patent/DK151232C/da not_active IP Right Cessation
- 1973-11-29 FR FR7342515A patent/FR2208886B1/fr not_active Expired
- 1973-11-30 BE BE138358A patent/BE808035A/xx not_active IP Right Cessation
- 1973-11-30 CH CH1687073A patent/CH605670A5/xx not_active IP Right Cessation
- 1973-12-03 GB GB5599173A patent/GB1397008A/en not_active Expired
- 1973-12-03 IL IL43735A patent/IL43735A/en unknown
- 1973-12-04 SE SE7316353A patent/SE404791B/xx unknown
- 1973-12-04 YU YU3132/73A patent/YU39232B/xx unknown
- 1973-12-04 SU SU1974541A patent/SU1253439A3/ru active
- 1973-12-04 HU HUBO1472A patent/HU168735B/hu unknown
- 1973-12-05 DD DD175142A patent/DD109377A5/xx unknown
- 1973-12-05 JP JP13601673A patent/JPS547781B2/ja not_active Expired
- 1973-12-05 AR AR251367A patent/AR199011A1/es active
- 1973-12-05 ZA ZA739238A patent/ZA739238B/xx unknown
-
1976
- 1976-09-13 SE SE7610106A patent/SE420322B/xx not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Clln. Glum. Acta, 31, 1971, 175-179. * |
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