SMT201600072B - Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide - Google Patents
Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammideInfo
- Publication number
- SMT201600072B SMT201600072B SM201600072T SM201600072T SMT201600072B SM T201600072 B SMT201600072 B SM T201600072B SM 201600072 T SM201600072 T SM 201600072T SM 201600072 T SM201600072 T SM 201600072T SM T201600072 B SMT201600072 B SM T201600072B
- Authority
- SM
- San Marino
- Prior art keywords
- carbossamide
- pirazine
- fluoro
- hydroxy
- sodium salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010221682 | 2010-09-30 | ||
| PCT/JP2011/072333 WO2012043700A1 (ja) | 2010-09-30 | 2011-09-29 | ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボキサミドのナトリウム塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600072B true SMT201600072B (it) | 2016-04-29 |
Family
ID=45893139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600072T SMT201600072B (it) | 2010-09-30 | 2016-03-14 | Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20130274472A1 (zh) |
| EP (1) | EP2623498B1 (zh) |
| JP (1) | JPWO2012043700A1 (zh) |
| CN (1) | CN103209966B (zh) |
| CY (1) | CY1117041T1 (zh) |
| DK (1) | DK2623498T3 (zh) |
| ES (1) | ES2554630T3 (zh) |
| HK (1) | HK1183015A1 (zh) |
| HR (1) | HRP20151263T1 (zh) |
| HU (1) | HUE026872T2 (zh) |
| MY (1) | MY161429A (zh) |
| PH (1) | PH12015501649B1 (zh) |
| PL (1) | PL2623498T3 (zh) |
| PT (1) | PT2623498E (zh) |
| RS (1) | RS54408B1 (zh) |
| SG (1) | SG189161A1 (zh) |
| SI (1) | SI2623498T1 (zh) |
| SM (1) | SMT201600072B (zh) |
| TW (1) | TWI552998B (zh) |
| WO (1) | WO2012043700A1 (zh) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| MX2012011022A (es) | 2010-03-24 | 2013-02-26 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas. |
| DK2623497T3 (en) * | 2010-09-30 | 2016-03-21 | Toyama Chemical Co Ltd | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide |
| EP2937348B1 (en) * | 2012-12-22 | 2021-09-08 | Kbp Biosciences Pte. Ltd. | Process for the preparation of a compound used as mineralocorticoid receptor antagonist |
| JP6487051B2 (ja) * | 2014-12-30 | 2019-03-20 | サムヤン バイオファーマシューティカルズ コーポレイションＳａｍｙａｎｇ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | ポリマーナノ粒子の凍結乾燥物、及びその製造方法 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| TW201808291A (zh) * | 2016-06-30 | 2018-03-16 | 富山化學工業股份有限公司 | 冷凍乾燥製劑之製造方法 |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US11679083B2 (en) * | 2017-12-28 | 2023-06-20 | Fujifilm Toyama Chemical Co., Ltd. | Method for producing freeze-dried formulation |
| KR20210094513A (ko) | 2018-11-19 | 2021-07-29 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 알코올-내성 약물 제형 |
| JP2022522270A (ja) | 2019-03-01 | 2022-04-15 | フラメル アイルランド リミテッド | 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物 |
| CN111249229B (zh) * | 2020-03-10 | 2023-05-02 | 北京阜康仁生物制药科技有限公司 | 一种稳定的法匹拉韦注射液及其制备方法 |
| TR202017792A2 (tr) * | 2020-11-06 | 2021-01-21 | Aroma Ilac Sanayi Ltd Sti | 6-floro-3-hidroksi-2-pirazinkarboksamid etken maddesi veya sodyum tuzunu içeren liyofilizasyon tekniğiyle üretilen yeni bir farmasötik kompozisyon |
| CN112574130B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药物共晶及其制备方法和应用 |
| CN112546234B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
| EP4265253A1 (en) | 2020-12-18 | 2023-10-25 | FUJIFILM Toyama Chemical Co., Ltd. | Pharmaceutical composition |
| JPWO2022131112A1 (zh) | 2020-12-18 | 2022-06-23 | ||
| WO2023033683A1 (ru) * | 2021-09-06 | 2023-03-09 | Общество С Ограниченной Ответственностью "Промомед Рус" | Противовирусная фармацевтическая композиция, содержащая фавипиравир и аминокислоту |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100435315B1 (ko) | 1998-01-07 | 2004-06-10 | 메이지 세이카 가부시키가이샤 | 결정학적으로 안정된 비정질 세파로스포린 조성물과 그제조 방법 |
| PT1112743E (pt) | 1998-08-20 | 2008-01-14 | Toyama Chemical Co Ltd | Derivados heterocíclicos azotados de carboxamidas ou os seus sais como agentes antivirais |
| CN1239511C (zh) | 2000-02-16 | 2006-02-01 | 富山化学工业株式会社 | 新的吡嗪衍生物或其盐、以及含有该衍生物或盐的药物组合物 |
| KR101479083B1 (ko) * | 2007-02-16 | 2015-01-07 | 토야마 케미칼 컴퍼니 리미티드 | 피라진 유도체를 함유하는 의약조성물 및 피라진 유도체를 조합하여 사용하는 방법 |
| JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
| JP2008231064A (ja) | 2007-03-23 | 2008-10-02 | Nippon Shokubai Co Ltd | カルバゾイルアルキル（メタ）アクリレートの製造方法 |
| BRPI0817305B1 (pt) * | 2007-09-27 | 2021-10-19 | Fujifilm Toyama Chemical Co., Ltd. | Sal de dicicloexilamina, e, processo para produzir um sal de dicicloexilamina |
| DK2407166T3 (da) | 2009-03-13 | 2013-10-07 | Toyama Chemical Co Ltd | Tablet og granuleret pulver indeholdende 6-fluor-3-hydroxy-2-pyrazin-carboxamid |
| DK2623497T3 (en) | 2010-09-30 | 2016-03-21 | Toyama Chemical Co Ltd | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide |
-
2011
- 2011-09-29 SI SI201130722T patent/SI2623498T1/sl unknown
- 2011-09-29 ES ES11829253.1T patent/ES2554630T3/es active Active
- 2011-09-29 WO PCT/JP2011/072333 patent/WO2012043700A1/ja active Application Filing
- 2011-09-29 PT PT118292531T patent/PT2623498E/pt unknown
- 2011-09-29 PL PL11829253T patent/PL2623498T3/pl unknown
- 2011-09-29 DK DK11829253.1T patent/DK2623498T3/en active
- 2011-09-29 SG SG2013023437A patent/SG189161A1/en unknown
- 2011-09-29 JP JP2012536536A patent/JPWO2012043700A1/ja active Pending
- 2011-09-29 EP EP11829253.1A patent/EP2623498B1/en active Active
- 2011-09-29 HU HUE11829253A patent/HUE026872T2/en unknown
- 2011-09-29 RS RS20150767A patent/RS54408B1/en unknown
- 2011-09-29 TW TW100135298A patent/TWI552998B/zh active
- 2011-09-29 MY MYPI2013001093A patent/MY161429A/en unknown
- 2011-09-29 CN CN201180055060.8A patent/CN103209966B/zh active Active
- 2011-09-29 US US13/876,998 patent/US20130274472A1/en not_active Abandoned
-
2013
- 2013-09-02 HK HK13110207.3A patent/HK1183015A1/zh unknown
-
2014
- 2014-10-16 US US14/515,673 patent/US9096547B2/en active Active
-
2015
- 2015-06-08 US US14/733,199 patent/US20150266831A1/en not_active Abandoned
- 2015-07-24 PH PH12015501649A patent/PH12015501649B1/en unknown
- 2015-11-24 HR HRP20151263TT patent/HRP20151263T1/hr unknown
- 2015-12-09 CY CY20151101124T patent/CY1117041T1/el unknown
-
2016
- 2016-03-14 SM SM201600072T patent/SMT201600072B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20151263T1 (hr) | 2015-12-18 |
| DK2623498T3 (en) | 2016-02-22 |
| ES2554630T3 (es) | 2015-12-22 |
| PH12015501649A1 (en) | 2015-10-05 |
| EP2623498A1 (en) | 2013-08-07 |
| PL2623498T3 (pl) | 2016-05-31 |
| TWI552998B (zh) | 2016-10-11 |
| EP2623498A4 (en) | 2014-03-26 |
| US9096547B2 (en) | 2015-08-04 |
| WO2012043700A1 (ja) | 2012-04-05 |
| US20150038713A1 (en) | 2015-02-05 |
| PT2623498E (pt) | 2016-02-02 |
| HK1183015A1 (zh) | 2013-12-13 |
| CN103209966A (zh) | 2013-07-17 |
| MY161429A (en) | 2017-04-14 |
| CY1117041T1 (el) | 2017-04-05 |
| SG189161A1 (en) | 2013-05-31 |
| CN103209966B (zh) | 2015-06-10 |
| RS54408B1 (en) | 2016-04-28 |
| SI2623498T1 (sl) | 2016-03-31 |
| EP2623498B1 (en) | 2015-11-18 |
| JPWO2012043700A1 (ja) | 2014-02-24 |
| US20130274472A1 (en) | 2013-10-17 |
| HUE026872T2 (en) | 2016-07-28 |
| US20150266831A1 (en) | 2015-09-24 |
| PH12015501649B1 (en) | 2015-10-05 |
| TW201219375A (en) | 2012-05-16 |
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