SMT201400101B - Derivati deuterati di isoindolina-1,3-dione come inibitori di pde4 e tnf-alfa - Google Patents

Derivati deuterati di isoindolina-1,3-dione come inibitori di pde4 e tnf-alfa

Info

Publication number
SMT201400101B
SMT201400101B SM201400101T SM201400101T SMT201400101B SM T201400101 B SMT201400101 B SM T201400101B SM 201400101 T SM201400101 T SM 201400101T SM 201400101 T SM201400101 T SM 201400101T SM T201400101 B SMT201400101 B SM T201400101B
Authority
SM
San Marino
Prior art keywords
pde4
isoindoline
alfa
dione
tnf
Prior art date
Application number
SM201400101T
Other languages
English (en)
Italian (it)
Inventor
Julie F Liu
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Publication of SMT201400101B publication Critical patent/SMT201400101B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
SM201400101T 2009-06-18 2014-07-29 Derivati deuterati di isoindolina-1,3-dione come inibitori di pde4 e tnf-alfa SMT201400101B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26895309P 2009-06-18 2009-06-18
PCT/US2010/038577 WO2010147922A1 (en) 2009-06-18 2010-06-15 Deuterated i soindoline- i, 3-dione derivatives as pde4 and tnf-alpha inhibitors

Publications (1)

Publication Number Publication Date
SMT201400101B true SMT201400101B (it) 2014-09-08

Family

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SM201400101T SMT201400101B (it) 2009-06-18 2014-07-29 Derivati deuterati di isoindolina-1,3-dione come inibitori di pde4 e tnf-alfa

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US (5) US8124646B2 (xx)
EP (3) EP2690092B1 (xx)
JP (2) JP5852565B2 (xx)
AU (1) AU2010260249B2 (xx)
BR (1) BRPI1012313B1 (xx)
CA (1) CA2765015C (xx)
DK (1) DK2443089T3 (xx)
EA (1) EA021019B1 (xx)
ES (2) ES2568629T3 (xx)
HK (1) HK1169651A1 (xx)
HR (1) HRP20140520T1 (xx)
ME (1) ME01883B (xx)
MX (1) MX2011013880A (xx)
PL (1) PL2443089T3 (xx)
PT (1) PT2443089E (xx)
RS (1) RS53357B (xx)
SI (1) SI2443089T1 (xx)
SM (1) SMT201400101B (xx)
WO (1) WO2010147922A1 (xx)

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EP2690092B1 (en) 2016-03-16
BRPI1012313B1 (pt) 2020-03-24
HK1169651A1 (en) 2013-02-01
EP2443089A1 (en) 2012-04-25
PL2443089T3 (pl) 2014-09-30
AU2010260249B2 (en) 2013-09-05
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