SMT201400087B - Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative - Google Patents
Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negativeInfo
- Publication number
- SMT201400087B SMT201400087B SM201400087T SM201400087T SMT201400087B SM T201400087 B SMT201400087 B SM T201400087B SM 201400087 T SM201400087 T SM 201400087T SM 201400087 T SM201400087 T SM 201400087T SM T201400087 B SMT201400087 B SM T201400087B
- Authority
- SM
- San Marino
- Prior art keywords
- histone
- philadelphia
- treatment
- deacetylase inhibitors
- myeloproliferative syndromes
- Prior art date
Links
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 230000002071 myeloproliferative effect Effects 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2008A001720A IT1392908B1 (it) | 2008-09-29 | 2008-09-29 | Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative |
| US19328308P | 2008-11-13 | 2008-11-13 | |
| PCT/EP2009/062214 WO2010034693A1 (en) | 2008-09-29 | 2009-09-21 | Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400087B true SMT201400087B (it) | 2014-09-08 |
Family
ID=40810309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400087T SMT201400087B (it) | 2008-09-29 | 2014-07-07 | Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20110294892A1 (enExample) |
| EP (1) | EP2344253B1 (enExample) |
| JP (1) | JP2012504112A (enExample) |
| KR (3) | KR20160096721A (enExample) |
| CN (1) | CN102164638A (enExample) |
| BR (1) | BRPI0913699A2 (enExample) |
| CA (1) | CA2738081C (enExample) |
| CY (1) | CY1115255T1 (enExample) |
| DK (1) | DK2344253T3 (enExample) |
| ES (1) | ES2478827T3 (enExample) |
| HR (1) | HRP20140499T1 (enExample) |
| IT (1) | IT1392908B1 (enExample) |
| PL (1) | PL2344253T3 (enExample) |
| PT (1) | PT2344253E (enExample) |
| SI (1) | SI2344253T1 (enExample) |
| SM (1) | SMT201400087B (enExample) |
| WO (1) | WO2010034693A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8217079B2 (en) * | 2010-03-26 | 2012-07-10 | Italfarmaco Spa | Method for treating Philadelphia-negative myeloproliferative syndromes |
| WO2015165975A1 (en) * | 2014-04-29 | 2015-11-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating myeloid neoplasias |
| TW201821105A (zh) | 2016-10-20 | 2018-06-16 | 美商弗瑪治療公司 | 使用ｈｄａｃ１１抑制劑之方法 |
| US10865328B2 (en) * | 2017-02-20 | 2020-12-15 | Dow Silicones Corporation | Room-temperature-curable silicone composition and electric/electronic apparatus |
| US11535607B2 (en) | 2018-04-20 | 2022-12-27 | Valo Health, Inc. | Isoindolines as HDAC inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| IT1283637B1 (it) | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| ITMI20030063A1 (it) * | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. |
| ITMI20030064A1 (it) * | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Uso dei derivati dell'acido idrossamico per la preparazione |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| WO2006063294A2 (en) * | 2004-12-09 | 2006-06-15 | Kalypsys, Inc. | Novel inhibitors of histone deacetylase for the treatment of disease |
| TW200730485A (en) * | 2005-07-29 | 2007-08-16 | Kalypsys Inc | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease |
| AU2006321710A1 (en) | 2005-12-09 | 2007-06-14 | Massachusetts Institute Of Technology | Methods for identifying and targeting tumor stem cells based on nuclear morphology |
| US20080242648A1 (en) * | 2006-11-10 | 2008-10-02 | Syndax Pharmaceuticals, Inc., A California Corporation | COMBINATION OF ERa+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER |
| US20110104177A1 (en) * | 2006-12-28 | 2011-05-05 | The Johns Hopkins University | Histone deacetylase inhibitors, combination therapies and methods of use |
-
2008
- 2008-09-29 IT ITMI2008A001720A patent/IT1392908B1/it active
-
2009
- 2009-09-21 ES ES09783251.3T patent/ES2478827T3/es active Active
- 2009-09-21 HR HRP20140499AT patent/HRP20140499T1/hr unknown
- 2009-09-21 KR KR1020167020675A patent/KR20160096721A/ko not_active Ceased
- 2009-09-21 BR BRPI0913699A patent/BRPI0913699A2/pt not_active Application Discontinuation
- 2009-09-21 KR KR1020117008487A patent/KR20110069075A/ko not_active Ceased
- 2009-09-21 CA CA2738081A patent/CA2738081C/en active Active
- 2009-09-21 JP JP2011528301A patent/JP2012504112A/ja active Pending
- 2009-09-21 WO PCT/EP2009/062214 patent/WO2010034693A1/en not_active Ceased
- 2009-09-21 KR KR1020177031565A patent/KR20170124640A/ko not_active Ceased
- 2009-09-21 EP EP09783251.3A patent/EP2344253B1/en active Active
- 2009-09-21 DK DK09783251.3T patent/DK2344253T3/da active
- 2009-09-21 CN CN2009801382462A patent/CN102164638A/zh active Pending
- 2009-09-21 SI SI200930963T patent/SI2344253T1/sl unknown
- 2009-09-21 PT PT97832513T patent/PT2344253E/pt unknown
- 2009-09-21 PL PL09783251T patent/PL2344253T3/pl unknown
-
2011
- 2011-03-25 US US13/064,450 patent/US20110294892A1/en not_active Abandoned
-
2013
- 2013-10-07 US US14/047,391 patent/US9522127B2/en active Active
-
2014
- 2014-07-07 SM SM201400087T patent/SMT201400087B/xx unknown
- 2014-07-09 CY CY20141100514T patent/CY1115255T1/el unknown
-
2016
- 2016-11-09 US US15/346,926 patent/US20170049740A1/en not_active Abandoned
-
2021
- 2021-01-15 US US17/149,794 patent/US20210128512A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20140499T1 (hr) | 2014-07-04 |
| US20110294892A1 (en) | 2011-12-01 |
| IT1392908B1 (it) | 2012-04-02 |
| US20210128512A1 (en) | 2021-05-06 |
| US9522127B2 (en) | 2016-12-20 |
| EP2344253A1 (en) | 2011-07-20 |
| ITMI20081720A1 (it) | 2010-03-30 |
| ES2478827T3 (es) | 2014-07-23 |
| KR20160096721A (ko) | 2016-08-16 |
| KR20110069075A (ko) | 2011-06-22 |
| EP2344253B1 (en) | 2014-04-23 |
| BRPI0913699A2 (pt) | 2017-06-13 |
| CA2738081C (en) | 2017-11-07 |
| US20170049740A1 (en) | 2017-02-23 |
| PT2344253E (pt) | 2014-07-16 |
| US20140039059A1 (en) | 2014-02-06 |
| PL2344253T3 (pl) | 2014-09-30 |
| DK2344253T3 (da) | 2014-06-16 |
| SI2344253T1 (sl) | 2014-08-29 |
| CA2738081A1 (en) | 2010-04-01 |
| WO2010034693A1 (en) | 2010-04-01 |
| CY1115255T1 (el) | 2017-01-04 |
| CN102164638A (zh) | 2011-08-24 |
| KR20170124640A (ko) | 2017-11-10 |
| JP2012504112A (ja) | 2012-02-16 |
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