SMT201300133B - Nuove forme polimorfe di 6-(1-metil-1H-pirazol-4-IL)-2-[[3-[5-(-morfolin-4-IL-etossi)-pirimidin-2-IL]-benzil]]-2H-piridazin-3-one diidrogenofosfato e procedimenti per la loro produzione - Google Patents

Nuove forme polimorfe di 6-(1-metil-1H-pirazol-4-IL)-2-[[3-[5-(-morfolin-4-IL-etossi)-pirimidin-2-IL]-benzil]]-2H-piridazin-3-one diidrogenofosfato e procedimenti per la loro produzione

Info

Publication number
SMT201300133B
SMT201300133B SM201300133T SM201300133T SMT201300133B SM T201300133 B SMT201300133 B SM T201300133B SM 201300133 T SM201300133 T SM 201300133T SM 201300133 T SM201300133 T SM 201300133T SM T201300133 B SMT201300133 B SM T201300133B
Authority
SM
San Marino
Prior art keywords
morfolin
pyridazin
pyrazol
pyrimidin
ethoxy
Prior art date
Application number
SM201300133T
Other languages
English (en)
Italian (it)
Inventor
Dieter Dorsch
Frank Stieber
Clemens Kuehn
Eva Kriegbaum
Oliver Schadt
Axel Becker
Christoph Saal
Cristina Donini
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41609799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201300133(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SMT201300133B publication Critical patent/SMT201300133B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SM201300133T 2008-12-22 2013-11-13 Nuove forme polimorfe di 6-(1-metil-1H-pirazol-4-IL)-2-[[3-[5-(-morfolin-4-IL-etossi)-pirimidin-2-IL]-benzil]]-2H-piridazin-3-one diidrogenofosfato e procedimenti per la loro produzione SMT201300133B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08022253 2008-12-22
PCT/EP2009/008358 WO2010072295A1 (en) 2008-12-22 2009-11-24 Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof

Publications (1)

Publication Number Publication Date
SMT201300133B true SMT201300133B (it) 2014-03-07

Family

ID=41609799

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201300133T SMT201300133B (it) 2008-12-22 2013-11-13 Nuove forme polimorfe di 6-(1-metil-1H-pirazol-4-IL)-2-[[3-[5-(-morfolin-4-IL-etossi)-pirimidin-2-IL]-benzil]]-2H-piridazin-3-one diidrogenofosfato e procedimenti per la loro produzione

Country Status (32)

Country Link
US (1) US8586599B2 (zh)
EP (1) EP2361250B1 (zh)
JP (2) JP5690741B2 (zh)
KR (1) KR101663335B1 (zh)
CN (1) CN102264729B (zh)
AR (1) AR074686A1 (zh)
AU (1) AU2009331990B2 (zh)
BR (1) BRPI0923480B8 (zh)
CA (1) CA2748218C (zh)
CL (1) CL2011001278A1 (zh)
CO (1) CO6331435A2 (zh)
CY (1) CY1114659T1 (zh)
DK (1) DK2361250T3 (zh)
EA (1) EA019320B1 (zh)
EC (1) ECSP11011219A (zh)
ES (1) ES2434247T3 (zh)
HK (1) HK1164837A1 (zh)
HR (1) HRP20130993T1 (zh)
IL (1) IL213647A (zh)
MX (1) MX2011006682A (zh)
MY (1) MY160526A (zh)
NZ (1) NZ594172A (zh)
PE (1) PE20120016A1 (zh)
PL (1) PL2361250T3 (zh)
PT (1) PT2361250E (zh)
SG (1) SG172128A1 (zh)
SI (1) SI2361250T1 (zh)
SM (1) SMT201300133B (zh)
TW (1) TWI448463B (zh)
UA (1) UA103646C2 (zh)
WO (1) WO2010072295A1 (zh)
ZA (1) ZA201105394B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062826A1 (de) * 2008-12-23 2010-07-01 Merck Patent Gmbh Pyridazinonderivate
KR20180092096A (ko) 2017-02-08 2018-08-17 에이비온 주식회사 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법
CN111465602B (zh) 2017-10-17 2023-05-23 帕劳制药有限公司 4-氨基嘧啶化合物的合成

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604388A1 (de) 1996-02-07 1997-08-14 Merck Patent Gmbh Arylalkyl-diazinone
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
AUPQ462299A0 (en) 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. Pyrazolopyridine compound and pharmaceutical use thereof
US6242461B1 (en) 2000-01-25 2001-06-05 Pfizer Inc. Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases
EP1463509A1 (en) 2001-10-31 2004-10-06 MERCK PATENT GmbH Type 4 phosphodiesterase inhibitors and uses thereof
CA2510298A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
CA2530589A1 (en) 2003-07-02 2005-01-20 Sugen Inc. Arylmethyl triazolo and imidazopyrazines as c-met inhibitors
US7959919B2 (en) 2003-11-19 2011-06-14 Novelmed Therapeutics, Inc. Method of inhibiting factor B-mediated complement activation
TW200612918A (en) 2004-07-29 2006-05-01 Threshold Pharmaceuticals Inc Lonidamine analogs
US20070015771A1 (en) 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
US20070043057A1 (en) 2005-02-09 2007-02-22 Threshold Pharmaceuticals, Inc. Lonidamine analogs
WO2007044796A2 (en) 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
WO2007064797A2 (en) 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
DE102005057924A1 (de) 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
KR101412675B1 (ko) 2005-12-21 2014-07-03 얀센 파마슈티카 엔.브이. 티로신 키나제 모듈레이터로서의 트리아졸로피리다진
WO2007130383A2 (en) 2006-04-28 2007-11-15 Northwestern University Compositions and treatments using pyridazine compounds and secretases
NL2000613C2 (nl) 2006-05-11 2007-11-20 Pfizer Prod Inc Triazoolpyrazinederivaten.
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
AR068876A1 (es) 2007-10-16 2009-12-09 Novartis Ag Heterociclos utiles como modulador de los receptores npy y y2 y composiciones farmaceuticas que los contienen
CN101910158A (zh) 2007-10-25 2010-12-08 阿斯利康(瑞典)有限公司 可用于治疗细胞增殖性病症的吡啶衍生物和吡嗪衍生物
MX2010004705A (es) 2007-10-31 2010-05-27 Nissan Chemical Ind Ltd Derivados de piridazinona y uso de los mismos como inhibidores del receptor p2x7.
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
CL2008003785A1 (es) 2007-12-21 2009-10-09 Du Pont Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada.
PL2235012T3 (pl) 2007-12-21 2013-12-31 Palau Pharma Sa Pochodne 4-amino-pirymidyny jako antagoniści receptora H<sub>4</sub> histaminowego
CL2008003799A1 (es) 2007-12-21 2009-12-18 Synthon Bv Composicion farmaceutica que comprende raloxifeno en forma de tableta de liberacion inmediata; util para el tratamiento y/o prevencion de la osteoporosis.
PE20091339A1 (es) 2007-12-21 2009-09-26 Glaxo Group Ltd Derivados de oxadiazol con actividad sobre receptores s1p1
WO2009080533A1 (en) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as orexin receptor antagonists
US7816540B2 (en) 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
TW200930375A (en) 2007-12-21 2009-07-16 Exelixis Inc Benzofuropyrimidinones
NZ586913A (en) 2007-12-21 2012-06-29 Astrazeneca Ab Bicyclic derivatives for use in the treatment of androgen receptor associated conditions
EP2072506A1 (de) 2007-12-21 2009-06-24 Bayer CropScience AG Thiazolyloxyphenylamidine oder Thiadiazolyloxyphenylamidine und deren Verwendung als Fungizide
GB0725059D0 (en) 2007-12-21 2008-01-30 Syngenta Participations Ag Novel pyridazine derivatives
KR101610607B1 (ko) 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
CN101538245B (zh) 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
EP2328586A2 (en) 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
US20120028988A1 (en) 2009-03-30 2012-02-02 Sumitomo Chemical Company, Limited Use of pyridazinone compound for control of harmful arthropod pests
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton

Also Published As

Publication number Publication date
IL213647A (en) 2013-11-28
SI2361250T1 (sl) 2013-12-31
PL2361250T3 (pl) 2014-01-31
ES2434247T3 (es) 2013-12-16
AU2009331990A1 (en) 2011-08-11
TWI448463B (zh) 2014-08-11
MX2011006682A (es) 2011-07-13
JP5690741B2 (ja) 2015-03-25
WO2010072295A1 (en) 2010-07-01
HK1164837A1 (zh) 2012-09-28
EP2361250B1 (en) 2013-08-07
HRP20130993T1 (hr) 2013-11-22
DK2361250T3 (da) 2013-11-04
CA2748218A1 (en) 2010-07-01
US8586599B2 (en) 2013-11-19
EP2361250A1 (en) 2011-08-31
CL2011001278A1 (es) 2011-09-30
CN102264729B (zh) 2014-03-05
CY1114659T1 (el) 2016-10-05
JP5860125B2 (ja) 2016-02-16
US20110257180A1 (en) 2011-10-20
CO6331435A2 (es) 2011-10-20
ZA201105394B (en) 2012-03-28
AU2009331990B2 (en) 2016-04-14
AR074686A1 (es) 2011-02-02
SG172128A1 (en) 2011-07-28
MY160526A (en) 2017-03-15
BRPI0923480B1 (pt) 2020-10-13
NZ594172A (en) 2013-04-26
BRPI0923480B8 (pt) 2021-05-25
IL213647A0 (en) 2011-07-31
CN102264729A (zh) 2011-11-30
UA103646C2 (ru) 2013-11-11
PE20120016A1 (es) 2012-01-24
JP2015028093A (ja) 2015-02-12
ECSP11011219A (es) 2011-12-30
JP2012513417A (ja) 2012-06-14
KR20110089462A (ko) 2011-08-08
PT2361250E (pt) 2013-11-11
BRPI0923480A2 (pt) 2016-08-09
KR101663335B1 (ko) 2016-10-06
EA201100973A1 (ru) 2012-01-30
CA2748218C (en) 2017-08-29
TW201028409A (en) 2010-08-01
EA019320B1 (ru) 2014-02-28

Similar Documents

Publication Publication Date Title
EP2343522A4 (en) METHOD FOR DETERMINING ROAD SURFACE STATE
IL239277A0 (en) A method for identifying risk factors for diseases
EP2317849A4 (en) PROCESS FOR THE TREATMENT OF LUNG DISEASES WITH RHO KINASE INHIBITOR COMPOUNDS
BRPI0909367A2 (pt) calçado e método de fabricação do mesmo
EP2400969A4 (en) METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITORY COMPOUNDS
EP2064332A4 (en) TOTAL TOTAL GENOMAMPLIFICATION FOR THE IDENTIFICATION OF DISEASES
EP2157074A4 (en) PROCESS FOR THE PRODUCTION OF ACROLEINE
SMT201600131B (it) Procedimento per la produzione di piastrine
SI2321295T1 (sl) Derivati 4-(piridin-4-il)-1H-(1,3,5,)triazin-2-ona kot inhibitorji GSK3-beta za zdravljenje nevrodegenerativnih bolezni
SMT201400161B (it) Nuove forme poliformiche di sale di idrocloruro di3-(1-[[3-[5-1-metil-piperidin-4il metossi)-pirimidin-2-il]-benzil]]-6-osso-1,6-didro-piridazin-3-il-benzonitrile e procedimenti per la sua produzione
EP2330220A4 (en) METHOD FOR QUANTIFYING OR DETERMINING DNA
EP2246446A4 (en) METHOD FOR QUANTIFICATION OF TARGET SUBSTANCE
EP2267143A4 (en) METHODS FOR PRODUCING AMIDE COMPOUNDS
EP2142206A4 (en) METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESSES
EP2130924A4 (en) PROCESS FOR PRODUCING L-AMINO ACID OR NUCLEIC ACID
EP1932910A4 (en) PROCESS FOR THE PREPARATION OF MILKY ACID
SG10201404793VA (en) Method of detaching semi-conductor layers at low temperature
IL193089A0 (en) Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
SMT201300133B (it) Nuove forme polimorfe di 6-(1-metil-1H-pirazol-4-IL)-2-[[3-[5-(-morfolin-4-IL-etossi)-pirimidin-2-IL]-benzil]]-2H-piridazin-3-one diidrogenofosfato e procedimenti per la loro produzione
ZA201001052B (en) Process for the enantioselective enzymatic reduction of intermediates
GB0818921D0 (en) Method of TOC monitoring
HK1156857A1 (zh) 取代的嘧啶衍生物的製備方法
EP2195453A4 (en) METHOD FOR AMPLIFYING NUCLEIC ACID
EP2275407A4 (en) PROCESS FOR THE PREPARATION OF AMID OR LACTAM
EP2310955A4 (en) REGISTERING AN AGENT TO PROCESS MANAGEMENT OBJECTS UPDATES