SK9932002A3 - Novel process for the preparation of alpha-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof - Google Patents

Novel process for the preparation of alpha-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof Download PDF

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Publication number
SK9932002A3
SK9932002A3 SK993-2002A SK9932002A SK9932002A3 SK 9932002 A3 SK9932002 A3 SK 9932002A3 SK 9932002 A SK9932002 A SK 9932002A SK 9932002 A3 SK9932002 A3 SK 9932002A3
Authority
SK
Slovakia
Prior art keywords
tert
disulfophenyl
butylnitrone
disodium salt
reaction
Prior art date
Application number
SK993-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Jorgen Blixt
Henry Kruk
John Mcginley
Sergei Pouhov
John Vajda
Original Assignee
Astrazeneca Ab
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Centaur Pharmaceuticals Inc filed Critical Astrazeneca Ab
Publication of SK9932002A3 publication Critical patent/SK9932002A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK993-2002A 2000-01-10 2001-01-04 Novel process for the preparation of alpha-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof SK9932002A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0000055A SE0000055D0 (sv) 2000-01-10 2000-01-10 Novel process
PCT/SE2001/000007 WO2001051460A1 (en) 2000-01-10 2001-01-04 NOVEL PROCESS FOR THE PREPARATION OF α-(2-4-DISULFOPHENYL)-N-TERT-BUTYLNITRONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Publications (1)

Publication Number Publication Date
SK9932002A3 true SK9932002A3 (en) 2003-03-04

Family

ID=20278055

Family Applications (1)

Application Number Title Priority Date Filing Date
SK993-2002A SK9932002A3 (en) 2000-01-10 2001-01-04 Novel process for the preparation of alpha-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof

Country Status (32)

Country Link
US (1) US6479697B2 (zh)
EP (1) EP1265856B1 (zh)
JP (1) JP3748821B2 (zh)
KR (1) KR100687167B1 (zh)
CN (1) CN1198798C (zh)
AR (1) AR029431A1 (zh)
AT (1) ATE263753T1 (zh)
AU (1) AU783255B2 (zh)
BR (1) BR0107483A (zh)
CA (1) CA2395971A1 (zh)
CO (1) CO5280203A1 (zh)
DE (1) DE60102679T2 (zh)
DK (1) DK1265856T3 (zh)
EE (1) EE200200385A (zh)
ES (1) ES2217114T3 (zh)
HU (1) HU225298B1 (zh)
IL (2) IL150403A0 (zh)
IS (1) IS6456A (zh)
MX (1) MXPA02006674A (zh)
MY (1) MY122830A (zh)
NO (1) NO20023316D0 (zh)
NZ (1) NZ519828A (zh)
PL (1) PL357106A1 (zh)
PT (1) PT1265856E (zh)
RU (1) RU2259996C2 (zh)
SE (1) SE0000055D0 (zh)
SK (1) SK9932002A3 (zh)
TR (1) TR200401307T4 (zh)
TW (1) TW572880B (zh)
UA (1) UA71653C2 (zh)
WO (1) WO2001051460A1 (zh)
ZA (1) ZA200204872B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1821016B1 (en) 2002-02-14 2014-04-09 Videojet Technologies Inc. Solenoid valve
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
EP1829668A1 (en) * 2004-12-01 2007-09-05 Toyo Boseki Kabushiki Kasisha Polyester resin film and process for producing the same
CA2927595C (en) 2004-12-22 2023-01-31 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
CA2715326C (en) 2008-02-12 2017-06-13 Tosk, Incorporated Toxicity-reducing nitrone adjuvants for doxorubicin and use of the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1437188A (fr) * 1964-06-17 1966-04-29 Du Pont Procédé de fabrication d'alpha-phényl-nu-méthyl nitrone
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
SE9802507D0 (sv) * 1998-07-10 1998-07-10 Astra Ab Novel salts

Also Published As

Publication number Publication date
ZA200204872B (en) 2003-10-07
US6479697B2 (en) 2002-11-12
DE60102679D1 (de) 2004-05-13
IL150403A (en) 2007-06-03
UA71653C2 (en) 2004-12-15
KR20020091077A (ko) 2002-12-05
EP1265856B1 (en) 2004-04-07
EE200200385A (et) 2003-12-15
HUP0204111A3 (en) 2005-05-30
HUP0204111A2 (hu) 2003-03-28
NO20023316L (no) 2002-07-09
CN1395559A (zh) 2003-02-05
IL150403A0 (en) 2002-12-01
AR029431A1 (es) 2003-06-25
NO20023316D0 (no) 2002-07-09
PL357106A1 (en) 2004-07-12
ATE263753T1 (de) 2004-04-15
SE0000055D0 (sv) 2000-01-10
KR100687167B1 (ko) 2007-02-27
ES2217114T3 (es) 2004-11-01
TW572880B (en) 2004-01-21
BR0107483A (pt) 2002-09-03
CA2395971A1 (en) 2001-07-19
DK1265856T3 (da) 2004-07-05
CO5280203A1 (es) 2003-05-30
DE60102679T2 (de) 2004-12-09
AU2720301A (en) 2001-07-24
MY122830A (en) 2006-05-31
WO2001051460A1 (en) 2001-07-19
RU2259996C2 (ru) 2005-09-10
HU225298B1 (en) 2006-09-28
MXPA02006674A (es) 2004-09-10
RU2002118320A (ru) 2004-02-27
CN1198798C (zh) 2005-04-27
US20020128318A1 (en) 2002-09-12
AU783255B2 (en) 2005-10-06
EP1265856A1 (en) 2002-12-18
NZ519828A (en) 2004-11-26
JP3748821B2 (ja) 2006-02-22
PT1265856E (pt) 2004-07-30
JP2003519678A (ja) 2003-06-24
TR200401307T4 (tr) 2004-07-21
IS6456A (is) 2002-07-04

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