SK6992000A3 - Compounds useful as competitive inhibitors of trypsin-like serine proteases, method for the preparation thereof, pharmaceutical compositions containing same and their use - Google Patents
Compounds useful as competitive inhibitors of trypsin-like serine proteases, method for the preparation thereof, pharmaceutical compositions containing same and their use Download PDFInfo
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- SK6992000A3 SK6992000A3 SK699-2000A SK6992000A SK6992000A3 SK 6992000 A3 SK6992000 A3 SK 6992000A3 SK 6992000 A SK6992000 A SK 6992000A SK 6992000 A3 SK6992000 A3 SK 6992000A3
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 152
- 238000000034 method Methods 0.000 title claims description 42
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
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- 108010036927 trypsin-like serine protease Proteins 0.000 title description 5
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- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- QIWRFOJWQSSRJZ-UHFFFAOYSA-N tributyl(ethenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C=C QIWRFOJWQSSRJZ-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704543A SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | New compounds |
| PCT/SE1998/002187 WO1999029664A1 (en) | 1997-12-05 | 1998-12-01 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK6992000A3 true SK6992000A3 (en) | 2001-02-12 |
Family
ID=20409280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK699-2000A SK6992000A3 (en) | 1997-12-05 | 1998-12-01 | Compounds useful as competitive inhibitors of trypsin-like serine proteases, method for the preparation thereof, pharmaceutical compositions containing same and their use |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6337394B2 (pt) |
| EP (1) | EP1036061B1 (pt) |
| JP (1) | JP2001525394A (pt) |
| KR (1) | KR100587434B1 (pt) |
| CN (1) | CN100379722C (pt) |
| AT (1) | ATE250574T1 (pt) |
| AU (1) | AU748834B2 (pt) |
| BR (1) | BR9813410A (pt) |
| CA (1) | CA2312431C (pt) |
| DE (1) | DE69818510T2 (pt) |
| EE (1) | EE200000322A (pt) |
| HU (1) | HUP0102681A3 (pt) |
| ID (1) | ID28008A (pt) |
| IL (1) | IL136295A (pt) |
| IS (1) | IS5511A (pt) |
| NO (1) | NO317096B1 (pt) |
| NZ (1) | NZ504528A (pt) |
| PL (1) | PL341047A1 (pt) |
| SE (1) | SE9704543D0 (pt) |
| SK (1) | SK6992000A3 (pt) |
| TR (1) | TR200001554T2 (pt) |
| WO (1) | WO1999029664A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| WO2002050056A1 (en) | 2000-12-18 | 2002-06-27 | Merck & Co., Inc. | Benzylamine derivatives and their use as thrombin inhibitors |
| US7144899B2 (en) | 2001-02-09 | 2006-12-05 | Merck & Co., Inc. | Thrombin inhibitors |
| SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
| AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| ATE378334T1 (de) * | 2003-05-21 | 2007-11-15 | Boehringer Ingelheim Int | Verbindungen als hepatitis c inhibitoren |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| ATE512971T1 (de) * | 2004-07-20 | 2011-07-15 | Boehringer Ingelheim Int | Peptidanaloga als hepatitis c-hemmer |
| UY29016A1 (es) * | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
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| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| AU600226B2 (en) | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897514B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (pt) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| CA2131367A1 (en) | 1992-03-04 | 1993-09-16 | Sandor Bajusz | New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof |
| TW223629B (pt) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| US5780631A (en) | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
| EA002767B1 (ru) | 1995-02-10 | 2002-08-29 | Басф Акциенгезельшафт | Ингибиторы тромбина |
| MX9706069A (es) * | 1995-02-17 | 1997-10-31 | Basf Ag | Nuevos inhibidores de la trombina. |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| US5914319A (en) | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| EP0820453A4 (en) | 1995-04-04 | 2001-08-29 | Merck & Co Inc | THROMBIN INHIBITORS |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| TW541316B (en) | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| JPH1095898A (ja) | 1996-09-25 | 1998-04-14 | Sumitomo Bakelite Co Ltd | 難燃性樹脂組成物およびこれを用いた積層板 |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
-
1997
- 1997-12-05 SE SE9704543A patent/SE9704543D0/xx unknown
-
1998
- 1998-12-01 CN CNB988134756A patent/CN100379722C/zh not_active Expired - Fee Related
- 1998-12-01 WO PCT/SE1998/002187 patent/WO1999029664A1/en active IP Right Grant
- 1998-12-01 HU HU0102681A patent/HUP0102681A3/hu unknown
- 1998-12-01 BR BR9813410-8A patent/BR9813410A/pt not_active Application Discontinuation
- 1998-12-01 US US09/214,143 patent/US6337394B2/en not_active Expired - Fee Related
- 1998-12-01 AT AT98962750T patent/ATE250574T1/de not_active IP Right Cessation
- 1998-12-01 DE DE69818510T patent/DE69818510T2/de not_active Expired - Lifetime
- 1998-12-01 CA CA002312431A patent/CA2312431C/en not_active Expired - Fee Related
- 1998-12-01 SK SK699-2000A patent/SK6992000A3/sk unknown
- 1998-12-01 KR KR1020007006078A patent/KR100587434B1/ko not_active IP Right Cessation
- 1998-12-01 AU AU17912/99A patent/AU748834B2/en not_active Ceased
- 1998-12-01 PL PL98341047A patent/PL341047A1/xx not_active Application Discontinuation
- 1998-12-01 JP JP2000524261A patent/JP2001525394A/ja active Pending
- 1998-12-01 TR TR2000/01554T patent/TR200001554T2/xx unknown
- 1998-12-01 ID IDW20001009A patent/ID28008A/id unknown
- 1998-12-01 NZ NZ504528A patent/NZ504528A/en unknown
- 1998-12-01 EE EEP200000322A patent/EE200000322A/xx unknown
- 1998-12-01 EP EP98962750A patent/EP1036061B1/en not_active Expired - Lifetime
-
2000
- 2000-05-22 IL IL136295A patent/IL136295A/en not_active IP Right Cessation
- 2000-05-26 IS IS5511A patent/IS5511A/is unknown
- 2000-06-02 NO NO20002848A patent/NO317096B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20010046981A1 (en) | 2001-11-29 |
| NO20002848D0 (no) | 2000-06-02 |
| NO317096B1 (no) | 2004-08-09 |
| DE69818510D1 (de) | 2003-10-30 |
| SE9704543D0 (sv) | 1997-12-05 |
| NZ504528A (en) | 2002-03-01 |
| ID28008A (id) | 2001-05-03 |
| CA2312431A1 (en) | 1999-06-17 |
| IL136295A (en) | 2009-02-11 |
| EP1036061A1 (en) | 2000-09-20 |
| KR20010024676A (ko) | 2001-03-26 |
| AU748834B2 (en) | 2002-06-13 |
| BR9813410A (pt) | 2000-10-10 |
| EE200000322A (et) | 2001-08-15 |
| CA2312431C (en) | 2008-01-22 |
| TR200001554T2 (tr) | 2001-01-22 |
| ATE250574T1 (de) | 2003-10-15 |
| IS5511A (is) | 2000-05-26 |
| CN100379722C (zh) | 2008-04-09 |
| PL341047A1 (en) | 2001-03-26 |
| EP1036061B1 (en) | 2003-09-24 |
| WO1999029664A1 (en) | 1999-06-17 |
| HUP0102681A3 (en) | 2002-01-28 |
| US6337394B2 (en) | 2002-01-08 |
| JP2001525394A (ja) | 2001-12-11 |
| CN1284063A (zh) | 2001-02-14 |
| KR100587434B1 (ko) | 2006-06-08 |
| HUP0102681A2 (hu) | 2001-12-28 |
| DE69818510T2 (de) | 2004-06-24 |
| AU1791299A (en) | 1999-06-28 |
| NO20002848L (no) | 2000-08-07 |
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