SK68694A3 - Peptides phosphinyloxymethylketones as inhibitors of enzyme converting interleukin-1-beta - Google Patents

Peptides phosphinyloxymethylketones as inhibitors of enzyme converting interleukin-1-beta Download PDF

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Publication number
SK68694A3
SK68694A3 SK686-94A SK68694A SK68694A3 SK 68694 A3 SK68694 A3 SK 68694A3 SK 68694 A SK68694 A SK 68694A SK 68694 A3 SK68694 A3 SK 68694A3
Authority
SK
Slovakia
Prior art keywords
mono
group
benzyloxycarbonyl
valyl
ketone
Prior art date
Application number
SK686-94A
Other languages
English (en)
Slovak (sk)
Inventor
Roland E Dolle
Jasbir Singh
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of SK68694A3 publication Critical patent/SK68694A3/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32Esters thereof
    • C07F9/3258Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/48Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
    • C07F9/4866Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof the ester moiety containing a substituent or structure which is considered as characteristic
SK686-94A 1993-06-04 1994-06-06 Peptides phosphinyloxymethylketones as inhibitors of enzyme converting interleukin-1-beta SK68694A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7321993A 1993-06-04 1993-06-04

Publications (1)

Publication Number Publication Date
SK68694A3 true SK68694A3 (en) 1995-02-08

Family

ID=22112457

Family Applications (1)

Application Number Title Priority Date Filing Date
SK686-94A SK68694A3 (en) 1993-06-04 1994-06-06 Peptides phosphinyloxymethylketones as inhibitors of enzyme converting interleukin-1-beta

Country Status (15)

Country Link
EP (1) EP0644197B1 (de)
JP (1) JPH0725887A (de)
KR (1) KR950000717A (de)
AT (1) ATE170868T1 (de)
AU (1) AU685447B2 (de)
CA (1) CA2125080A1 (de)
CZ (1) CZ137994A3 (de)
DE (1) DE69413167T2 (de)
DK (1) DK0644197T3 (de)
ES (1) ES2122145T3 (de)
FI (1) FI942625A (de)
IL (1) IL109901A (de)
NO (1) NO304983B1 (de)
NZ (1) NZ260675A (de)
SK (1) SK68694A3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
AU5122196A (en) * 1995-03-31 1996-10-16 Takeda Chemical Industries Ltd. Cysteine protease inhibitor
AU6458396A (en) * 1995-07-17 1997-02-18 Cephalon, Inc. Phosphorous-containing cysteine and serine protease inhibitors
US5639732A (en) * 1996-07-10 1997-06-17 Cephalon, Inc. Phosphorous-containing cysteine and serine protease inhibitors
EP1389624A1 (de) * 1995-07-17 2004-02-18 Cephalon, Inc. Phosphor enthaltende Hemmer von Cystein- und Serin-Proteasen
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
WO1997046578A1 (en) 1996-06-07 1997-12-11 Zeneca Limited Peptide derivatives
GB9621836D0 (en) * 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
WO1999046248A1 (en) 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
KR100898094B1 (ko) 1998-03-19 2009-05-18 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제
US6919437B1 (en) 1998-06-11 2005-07-19 Isis Pharmaceuticals, Inc. Synthetic methods and intermediates for triester oligonucleotides
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
KR100448008B1 (ko) 2002-07-20 2004-09-08 주식회사 효성 고강도 저수축 폴리에스테르 섬유 및 그 제조방법
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
US7531570B2 (en) 2004-05-27 2009-05-12 Vertex Pharmaceuticals Incorporated Treatment of diseases using ICE inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE257517T1 (de) * 1991-08-30 2004-01-15 Vertex Pharma Interleukin 1-beta protease und ihre inhibitoren
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
EP0644197A1 (de) 1995-03-22
AU685447B2 (en) 1998-01-22
KR950000717A (ko) 1995-01-03
ATE170868T1 (de) 1998-09-15
NO304983B1 (no) 1999-03-15
FI942625A0 (fi) 1994-06-03
JPH0725887A (ja) 1995-01-27
CA2125080A1 (en) 1994-12-05
NO942065L (no) 1994-12-05
ES2122145T3 (es) 1998-12-16
CZ137994A3 (en) 1995-06-14
DE69413167D1 (de) 1998-10-15
IL109901A0 (en) 1994-10-07
NZ260675A (en) 1996-04-26
FI942625A (fi) 1994-12-05
IL109901A (en) 1999-06-20
DK0644197T3 (da) 1999-06-07
AU6451494A (en) 1994-12-08
EP0644197B1 (de) 1998-09-09
NO942065D0 (no) 1994-06-03
DE69413167T2 (de) 1999-05-06

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