SK6132002A3 - Polycyclic dihydrothiazole derivatives, the production thereof and their use as medicaments - Google Patents

Polycyclic dihydrothiazole derivatives, the production thereof and their use as medicaments Download PDF

Info

Publication number
SK6132002A3
SK6132002A3 SK613-2002A SK6132002A SK6132002A3 SK 6132002 A3 SK6132002 A3 SK 6132002A3 SK 6132002 A SK6132002 A SK 6132002A SK 6132002 A3 SK6132002 A3 SK 6132002A3
Authority
SK
Slovakia
Prior art keywords
alkyl
phenyl
group
cycloalkyl
atom
Prior art date
Application number
SK613-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Gerhard Jaehne
Matthias Gossel
Hans-Jochen Lang
Martin Bickel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000113306 external-priority patent/DE10013306A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of SK6132002A3 publication Critical patent/SK6132002A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK613-2002A 1999-11-05 2000-10-21 Polycyclic dihydrothiazole derivatives, the production thereof and their use as medicaments SK6132002A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19953205 1999-11-05
DE2000113306 DE10013306A1 (de) 2000-03-17 2000-03-17 Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2000/010396 WO2001032638A1 (fr) 1999-11-05 2000-10-21 Derives d'indeno-, naphto- et bencyclohepta-dihydrothiazol, leur preparation et leur utilisation comme medicaments anorexigenes

Publications (1)

Publication Number Publication Date
SK6132002A3 true SK6132002A3 (en) 2002-11-06

Family

ID=26004890

Family Applications (1)

Application Number Title Priority Date Filing Date
SK613-2002A SK6132002A3 (en) 1999-11-05 2000-10-21 Polycyclic dihydrothiazole derivatives, the production thereof and their use as medicaments

Country Status (27)

Country Link
US (1) US6387935B1 (fr)
EP (1) EP1230230B1 (fr)
JP (1) JP2003524632A (fr)
KR (1) KR20020047331A (fr)
CN (1) CN1176080C (fr)
AR (1) AR026338A1 (fr)
AT (1) ATE250045T1 (fr)
AU (1) AU777569B2 (fr)
BR (1) BR0015322A (fr)
CA (1) CA2389703A1 (fr)
CZ (1) CZ20021528A3 (fr)
DE (1) DE50003761D1 (fr)
DK (1) DK1230230T3 (fr)
EE (1) EE200200235A (fr)
ES (1) ES2206320T3 (fr)
HK (1) HK1050524A1 (fr)
HR (1) HRP20020379A2 (fr)
HU (1) HUP0203290A3 (fr)
IL (1) IL149400A0 (fr)
MX (1) MXPA02003477A (fr)
NO (1) NO322309B1 (fr)
NZ (1) NZ518751A (fr)
PL (1) PL354533A1 (fr)
PT (1) PT1230230E (fr)
SK (1) SK6132002A3 (fr)
WO (1) WO2001032638A1 (fr)
YU (1) YU29602A (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1734963A4 (fr) 2004-04-02 2008-06-18 Merck & Co Inc Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN105001219A (zh) 2011-02-25 2015-10-28 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
WO2012118972A2 (fr) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Procédé de préparation d'agonistes du guanylate cyclase c
KR20150036245A (ko) 2012-08-02 2015-04-07 머크 샤프 앤드 돔 코포레이션 항당뇨병 트리시클릭 화합물
BR112015019836A2 (pt) 2013-02-22 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
EP2970119B1 (fr) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CZ20021528A3 (cs) 2002-07-17
US6387935B1 (en) 2002-05-14
EP1230230A1 (fr) 2002-08-14
AR026338A1 (es) 2003-02-05
ES2206320T3 (es) 2004-05-16
PL354533A1 (en) 2004-01-26
AU777569B2 (en) 2004-10-21
AU1274601A (en) 2001-05-14
HK1050524A1 (en) 2003-06-27
CN1384827A (zh) 2002-12-11
EP1230230B1 (fr) 2003-09-17
NO20022021D0 (no) 2002-04-29
HUP0203290A2 (hu) 2003-01-28
KR20020047331A (ko) 2002-06-21
YU29602A (sh) 2006-01-16
EE200200235A (et) 2003-06-16
BR0015322A (pt) 2002-07-09
NO20022021L (no) 2002-04-29
DE50003761D1 (de) 2003-10-23
HUP0203290A3 (en) 2004-12-28
ATE250045T1 (de) 2003-10-15
MXPA02003477A (es) 2002-08-20
CA2389703A1 (fr) 2001-05-10
CN1176080C (zh) 2004-11-17
DK1230230T3 (da) 2003-12-15
NZ518751A (en) 2004-06-25
PT1230230E (pt) 2003-12-31
JP2003524632A (ja) 2003-08-19
IL149400A0 (en) 2002-11-10
WO2001032638A1 (fr) 2001-05-10
HRP20020379A2 (en) 2004-02-29
NO322309B1 (no) 2006-09-11

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