SK6012002A3 - Imidazole derivative as phosphodiesterase vii inhibitor, use thereof and pharmaceutical composition containing the same - Google Patents
Imidazole derivative as phosphodiesterase vii inhibitor, use thereof and pharmaceutical composition containing the same Download PDFInfo
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- SK6012002A3 SK6012002A3 SK601-2002A SK6012002A SK6012002A3 SK 6012002 A3 SK6012002 A3 SK 6012002A3 SK 6012002 A SK6012002 A SK 6012002A SK 6012002 A3 SK6012002 A3 SK 6012002A3
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- 150000002460 imidazoles Chemical class 0.000 title claims abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 title abstract description 15
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 11
- 239000012453 solvate Substances 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 8
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 8
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 6
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 5
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 5
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 39
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
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- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 claims description 3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954707A DE19954707A1 (de) | 1999-11-13 | 1999-11-13 | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| PCT/EP2000/010765 WO2001036425A2 (de) | 1999-11-13 | 2000-10-31 | Imidazolverbindungen als phosphodiesterase vii-hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK6012002A3 true SK6012002A3 (en) | 2002-09-10 |
Family
ID=7928973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK601-2002A SK6012002A3 (en) | 1999-11-13 | 2000-10-31 | Imidazole derivative as phosphodiesterase vii inhibitor, use thereof and pharmaceutical composition containing the same |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6884800B1 (https=) |
| EP (1) | EP1228073B1 (https=) |
| JP (1) | JP4819272B2 (https=) |
| KR (1) | KR20020049051A (https=) |
| CN (1) | CN1390222A (https=) |
| AR (1) | AR026421A1 (https=) |
| AT (1) | ATE245653T1 (https=) |
| AU (1) | AU775886B2 (https=) |
| BR (1) | BR0015487A (https=) |
| CA (1) | CA2391087A1 (https=) |
| CZ (1) | CZ20021474A3 (https=) |
| DE (2) | DE19954707A1 (https=) |
| DK (1) | DK1228073T3 (https=) |
| ES (1) | ES2200968T3 (https=) |
| HU (1) | HUP0203422A3 (https=) |
| MX (1) | MXPA02004728A (https=) |
| NO (1) | NO20022232L (https=) |
| PL (1) | PL355098A1 (https=) |
| PT (1) | PT1228073E (https=) |
| RU (1) | RU2002113759A (https=) |
| SK (1) | SK6012002A3 (https=) |
| WO (1) | WO2001036425A2 (https=) |
| ZA (1) | ZA200204729B (https=) |
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| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2008119057A2 (en) * | 2007-03-27 | 2008-10-02 | Omeros Corporation | The use of pde7 inhibitors for the treatment of movement disorders |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| DE102007047738A1 (de) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Imidazolderivate |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| NZ628054A (en) | 2010-11-08 | 2016-03-31 | Omeros Corp | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US11685745B2 (en) | 2017-07-12 | 2023-06-27 | Dart Neuroscience, Llc | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors |
| IL318817A (en) | 2022-08-18 | 2025-04-01 | Mitodicure Gmbh | Use of a therapeutic agent with PHOSPHODIESTERASE-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exercise intolerance |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2919271A (en) * | 1957-12-05 | 1959-12-29 | Smith Kline French Lab | 3-amino-1, 2-dihydro-3h-pyrido [3, 2, 1-kl]-phenothiazines |
| CA2051697C (en) * | 1989-06-09 | 1996-10-08 | Malcolm Wilson Moon | Heterocyclic amines having central nervous system activity |
| US5318965A (en) * | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
| ZA9810766B (en) * | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
-
1999
- 1999-11-13 DE DE19954707A patent/DE19954707A1/de not_active Withdrawn
-
2000
- 2000-10-31 PL PL00355098A patent/PL355098A1/xx unknown
- 2000-10-31 DE DE50003036T patent/DE50003036D1/de not_active Expired - Lifetime
- 2000-10-31 WO PCT/EP2000/010765 patent/WO2001036425A2/de not_active Ceased
- 2000-10-31 CN CN00815534A patent/CN1390222A/zh active Pending
- 2000-10-31 EP EP00975978A patent/EP1228073B1/de not_active Expired - Lifetime
- 2000-10-31 SK SK601-2002A patent/SK6012002A3/sk unknown
- 2000-10-31 KR KR1020027006131A patent/KR20020049051A/ko not_active Withdrawn
- 2000-10-31 HU HU0203422A patent/HUP0203422A3/hu unknown
- 2000-10-31 ES ES00975978T patent/ES2200968T3/es not_active Expired - Lifetime
- 2000-10-31 DK DK00975978T patent/DK1228073T3/da active
- 2000-10-31 CA CA002391087A patent/CA2391087A1/en not_active Abandoned
- 2000-10-31 AU AU13907/01A patent/AU775886B2/en not_active Ceased
- 2000-10-31 BR BR0015487-3A patent/BR0015487A/pt not_active Application Discontinuation
- 2000-10-31 US US10/129,629 patent/US6884800B1/en not_active Expired - Fee Related
- 2000-10-31 RU RU2002113759/04A patent/RU2002113759A/ru unknown
- 2000-10-31 MX MXPA02004728A patent/MXPA02004728A/es not_active Application Discontinuation
- 2000-10-31 JP JP2001538914A patent/JP4819272B2/ja not_active Expired - Fee Related
- 2000-10-31 PT PT00975978T patent/PT1228073E/pt unknown
- 2000-10-31 CZ CZ20021474A patent/CZ20021474A3/cs unknown
- 2000-10-31 AT AT00975978T patent/ATE245653T1/de not_active IP Right Cessation
- 2000-11-10 AR ARP000105929A patent/AR026421A1/es unknown
-
2002
- 2002-05-10 NO NO20022232A patent/NO20022232L/no not_active Application Discontinuation
- 2002-06-12 ZA ZA200204729A patent/ZA200204729B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1228073B1 (de) | 2003-07-23 |
| ATE245653T1 (de) | 2003-08-15 |
| AR026421A1 (es) | 2003-02-12 |
| CA2391087A1 (en) | 2001-05-25 |
| JP2003514821A (ja) | 2003-04-22 |
| DK1228073T3 (da) | 2003-11-03 |
| DE50003036D1 (de) | 2003-08-28 |
| WO2001036425A2 (de) | 2001-05-25 |
| MXPA02004728A (es) | 2002-08-30 |
| CZ20021474A3 (cs) | 2002-07-17 |
| JP4819272B2 (ja) | 2011-11-24 |
| KR20020049051A (ko) | 2002-06-24 |
| RU2002113759A (ru) | 2004-01-10 |
| DE19954707A1 (de) | 2001-05-17 |
| HUP0203422A3 (en) | 2004-12-28 |
| ES2200968T3 (es) | 2004-03-16 |
| US6884800B1 (en) | 2005-04-26 |
| NO20022232D0 (no) | 2002-05-10 |
| NO20022232L (no) | 2002-05-10 |
| EP1228073A2 (de) | 2002-08-07 |
| AU775886B2 (en) | 2004-08-19 |
| WO2001036425A3 (de) | 2002-01-10 |
| HUP0203422A2 (hu) | 2003-02-28 |
| PL355098A1 (en) | 2004-04-05 |
| AU1390701A (en) | 2001-05-30 |
| BR0015487A (pt) | 2002-07-02 |
| PT1228073E (pt) | 2003-12-31 |
| CN1390222A (zh) | 2003-01-08 |
| ZA200204729B (en) | 2003-11-26 |
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