SK59699A3 - 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors - Google Patents
1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors Download PDFInfo
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- SK59699A3 SK59699A3 SK596-99A SK59699A SK59699A3 SK 59699 A3 SK59699 A3 SK 59699A3 SK 59699 A SK59699 A SK 59699A SK 59699 A3 SK59699 A3 SK 59699A3
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- hiv
- compounds
- reverse transcriptase
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2974596P | 1996-11-08 | 1996-11-08 | |
| US74710496A | 1996-11-08 | 1996-11-08 | |
| PCT/US1997/020035 WO1998020008A1 (fr) | 1996-11-08 | 1997-11-04 | Urees 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cycliques utiles en tant qu'inhibiteurs de protease de vih |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK59699A3 true SK59699A3 (en) | 1999-12-10 |
Family
ID=26705293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK596-99A SK59699A3 (en) | 1996-11-08 | 1997-11-04 | 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0937067B1 (fr) |
| JP (1) | JP2001503428A (fr) |
| KR (1) | KR20000053122A (fr) |
| CN (1) | CN1235602A (fr) |
| AT (1) | ATE244714T1 (fr) |
| AU (1) | AU5165198A (fr) |
| BR (1) | BR9712910A (fr) |
| CA (1) | CA2270966A1 (fr) |
| CZ (1) | CZ157599A3 (fr) |
| DE (1) | DE69723456T2 (fr) |
| EA (1) | EA199900452A1 (fr) |
| EE (1) | EE9900188A (fr) |
| ES (1) | ES2202645T3 (fr) |
| HU (1) | HUP9904676A2 (fr) |
| IL (1) | IL129727A0 (fr) |
| LV (1) | LV12375B (fr) |
| NO (1) | NO992228L (fr) |
| PL (1) | PL333421A1 (fr) |
| SI (1) | SI20074A (fr) |
| SK (1) | SK59699A3 (fr) |
| WO (1) | WO1998020008A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6870098A (en) * | 1997-03-31 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| CN101415685B (zh) | 2006-01-31 | 2011-08-24 | 阿雷生物药品公司 | 激酶抑制剂及其使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5532357A (en) * | 1995-06-07 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
-
1997
- 1997-11-04 WO PCT/US1997/020035 patent/WO1998020008A1/fr not_active Application Discontinuation
- 1997-11-04 AU AU51651/98A patent/AU5165198A/en not_active Abandoned
- 1997-11-04 CZ CZ991575A patent/CZ157599A3/cs unknown
- 1997-11-04 EA EA199900452A patent/EA199900452A1/ru unknown
- 1997-11-04 AT AT97946494T patent/ATE244714T1/de not_active IP Right Cessation
- 1997-11-04 IL IL12972797A patent/IL129727A0/xx unknown
- 1997-11-04 SK SK596-99A patent/SK59699A3/sk unknown
- 1997-11-04 ES ES97946494T patent/ES2202645T3/es not_active Expired - Lifetime
- 1997-11-04 EE EEP199900188A patent/EE9900188A/xx unknown
- 1997-11-04 BR BR9712910A patent/BR9712910A/pt not_active Application Discontinuation
- 1997-11-04 CN CN97199419A patent/CN1235602A/zh active Pending
- 1997-11-04 HU HU9904676A patent/HUP9904676A2/hu unknown
- 1997-11-04 SI SI9720072A patent/SI20074A/sl unknown
- 1997-11-04 CA CA002270966A patent/CA2270966A1/fr not_active Abandoned
- 1997-11-04 DE DE69723456T patent/DE69723456T2/de not_active Expired - Fee Related
- 1997-11-04 KR KR1019990704048A patent/KR20000053122A/ko not_active Application Discontinuation
- 1997-11-04 EP EP97946494A patent/EP0937067B1/fr not_active Expired - Lifetime
- 1997-11-04 JP JP52168198A patent/JP2001503428A/ja active Pending
- 1997-11-04 PL PL97333421A patent/PL333421A1/xx unknown
-
1999
- 1999-04-29 LV LVP-99-76A patent/LV12375B/en unknown
- 1999-05-07 NO NO992228A patent/NO992228L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000053122A (ko) | 2000-08-25 |
| EP0937067A1 (fr) | 1999-08-25 |
| EP0937067B1 (fr) | 2003-07-09 |
| DE69723456T2 (de) | 2004-05-27 |
| ATE244714T1 (de) | 2003-07-15 |
| DE69723456D1 (de) | 2003-08-14 |
| EE9900188A (et) | 1999-12-15 |
| BR9712910A (pt) | 2000-03-21 |
| LV12375A (lv) | 1999-11-20 |
| PL333421A1 (en) | 1999-12-06 |
| ES2202645T3 (es) | 2004-04-01 |
| CA2270966A1 (fr) | 1998-05-14 |
| AU5165198A (en) | 1998-05-29 |
| IL129727A0 (en) | 2000-02-29 |
| EA199900452A1 (ru) | 2000-02-28 |
| CZ157599A3 (cs) | 1999-11-17 |
| WO1998020008A1 (fr) | 1998-05-14 |
| NO992228L (no) | 1999-06-07 |
| CN1235602A (zh) | 1999-11-17 |
| NO992228D0 (no) | 1999-05-07 |
| HUP9904676A2 (hu) | 2000-06-28 |
| LV12375B (en) | 2000-04-20 |
| JP2001503428A (ja) | 2001-03-13 |
| SI20074A (sl) | 2000-04-30 |
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