HUP9904676A2 - 1-(3-Aminoindazol-5-il)-3-fenilmetil-ciklusos karbamidok és HIV proteáz inhibitorként való alkalmazásuk - Google Patents

1-(3-Aminoindazol-5-il)-3-fenilmetil-ciklusos karbamidok és HIV proteáz inhibitorként való alkalmazásuk

Info

Publication number
HUP9904676A2
HUP9904676A2 HU9904676A HUP9904676A HUP9904676A2 HU P9904676 A2 HUP9904676 A2 HU P9904676A2 HU 9904676 A HU9904676 A HU 9904676A HU P9904676 A HUP9904676 A HU P9904676A HU P9904676 A2 HUP9904676 A2 HU P9904676A2
Authority
HU
Hungary
Prior art keywords
protease inhibitors
hiv protease
aminoindazol
phenylmethyl
cyclic ureas
Prior art date
Application number
HU9904676A
Other languages
English (en)
Inventor
Robert Frank Kaltenbach Iii.
James David Rodgers
Original Assignee
Du Pont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharmaceuticals Company filed Critical Du Pont Pharmaceuticals Company
Publication of HUP9904676A2 publication Critical patent/HUP9904676A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány (I) és (II) képletű vegyületekre vagy ezek gyógyászatilagelfőgadható sóira, ill. prő-drűgjaira vőnatkőzik, amelyekfelhasználhatók HIV-prőteáz-inhibitőrként. A találmány vőnatkőziktővábbá az ezeket tartalmazó gyógyászati készítményekre ésdiagnősztikai készletekre is. ŕ
HU9904676A 1996-11-08 1997-11-04 1-(3-Aminoindazol-5-il)-3-fenilmetil-ciklusos karbamidok és HIV proteáz inhibitorként való alkalmazásuk HUP9904676A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2974596P 1996-11-08 1996-11-08
US74710496A 1996-11-08 1996-11-08
PCT/US1997/020035 WO1998020008A1 (en) 1996-11-08 1997-11-04 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors

Publications (1)

Publication Number Publication Date
HUP9904676A2 true HUP9904676A2 (hu) 2000-06-28

Family

ID=26705293

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904676A HUP9904676A2 (hu) 1996-11-08 1997-11-04 1-(3-Aminoindazol-5-il)-3-fenilmetil-ciklusos karbamidok és HIV proteáz inhibitorként való alkalmazásuk

Country Status (21)

Country Link
EP (1) EP0937067B1 (hu)
JP (1) JP2001503428A (hu)
KR (1) KR20000053122A (hu)
CN (1) CN1235602A (hu)
AT (1) ATE244714T1 (hu)
AU (1) AU5165198A (hu)
BR (1) BR9712910A (hu)
CA (1) CA2270966A1 (hu)
CZ (1) CZ157599A3 (hu)
DE (1) DE69723456T2 (hu)
EA (1) EA199900452A1 (hu)
EE (1) EE9900188A (hu)
ES (1) ES2202645T3 (hu)
HU (1) HUP9904676A2 (hu)
IL (1) IL129727A0 (hu)
LV (1) LV12375B (hu)
NO (1) NO992228L (hu)
PL (1) PL333421A1 (hu)
SI (1) SI20074A (hu)
SK (1) SK59699A3 (hu)
WO (1) WO1998020008A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043969A1 (en) * 1997-03-31 1998-10-08 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
UA94733C2 (ru) 2006-01-31 2011-06-10 Эррей Биофарма Инк. Ингибиторы киназы и способы их использования

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas

Also Published As

Publication number Publication date
EP0937067A1 (en) 1999-08-25
NO992228D0 (no) 1999-05-07
JP2001503428A (ja) 2001-03-13
SK59699A3 (en) 1999-12-10
EP0937067B1 (en) 2003-07-09
LV12375B (en) 2000-04-20
EE9900188A (et) 1999-12-15
LV12375A (lv) 1999-11-20
CA2270966A1 (en) 1998-05-14
WO1998020008A1 (en) 1998-05-14
CN1235602A (zh) 1999-11-17
NO992228L (no) 1999-06-07
PL333421A1 (en) 1999-12-06
BR9712910A (pt) 2000-03-21
CZ157599A3 (cs) 1999-11-17
KR20000053122A (ko) 2000-08-25
DE69723456D1 (de) 2003-08-14
SI20074A (sl) 2000-04-30
ATE244714T1 (de) 2003-07-15
IL129727A0 (en) 2000-02-29
EA199900452A1 (ru) 2000-02-28
AU5165198A (en) 1998-05-29
ES2202645T3 (es) 2004-04-01
DE69723456T2 (de) 2004-05-27

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