SK57793A3 - Benzimidazole derivatives process for their preparation and their pharmaceutical compositions - Google Patents
Benzimidazole derivatives process for their preparation and their pharmaceutical compositions Download PDFInfo
- Publication number
- SK57793A3 SK57793A3 SK577-93A SK57793A SK57793A3 SK 57793 A3 SK57793 A3 SK 57793A3 SK 57793 A SK57793 A SK 57793A SK 57793 A3 SK57793 A3 SK 57793A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- formula
- compound
- oxo
- pyridazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4219409 | 1992-06-13 | ||
| DE4237656A DE4237656A1 (de) | 1992-06-13 | 1992-11-07 | Benzimidazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK57793A3 true SK57793A3 (en) | 1994-05-11 |
Family
ID=25915661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK577-93A SK57793A3 (en) | 1992-06-13 | 1993-06-08 | Benzimidazole derivatives process for their preparation and their pharmaceutical compositions |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5401738A (cs) |
| EP (1) | EP0574787A3 (cs) |
| JP (1) | JPH0665234A (cs) |
| CN (1) | CN1082542A (cs) |
| AU (1) | AU4123793A (cs) |
| CA (1) | CA2098243A1 (cs) |
| CZ (1) | CZ114493A3 (cs) |
| DE (1) | DE4237656A1 (cs) |
| HU (2) | HUT69712A (cs) |
| MX (1) | MX9303469A (cs) |
| NO (1) | NO932146L (cs) |
| PL (1) | PL299284A1 (cs) |
| SK (1) | SK57793A3 (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH082441Y2 (ja) * | 1987-06-01 | 1996-01-29 | トヨタ自動車株式会社 | 圧縮比切換装置 |
| DE4224133A1 (de) * | 1992-07-22 | 1994-01-27 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| WO1998006703A1 (en) | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| EP1123703B1 (en) * | 1998-10-23 | 2004-04-14 | Toray Industries, Inc. | Immunomodulatory drug composition |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| NZ515543A (en) * | 1999-06-22 | 2003-11-28 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| TWI225488B (en) * | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
| EP1537114B8 (en) * | 2002-08-07 | 2007-10-03 | Novartis AG | Organic compounds as agents for the treatment of aldosterone mediated conditions |
| MX2007014114A (es) | 2005-05-10 | 2008-03-14 | Intermune Inc | Derivados de piridona para modular el sistema de proteina cinasa activada por estres. |
| EP2058308A1 (fr) * | 2007-11-12 | 2009-05-13 | Merck Sante | Dérivés de benzimidazoledihydrothiadiazinone comme inhibiteurs de fructose-1,6-biphosphatase et compositions pharmaceutiques les contenant. |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| EP2858983B1 (en) * | 2012-06-11 | 2018-04-18 | UCB Biopharma SPRL | Tnf-alpha modulating benzimidazoles |
| WO2013185284A1 (en) | 2012-06-12 | 2013-12-19 | Abbott Laboratories | Pyridinone and pyridazinone derivatives |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN104370889A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类降低眼压的化合物及其制备方法和用途 |
| JP6525437B2 (ja) | 2014-04-02 | 2019-06-05 | インターミューン， インコーポレイテッド | 抗線維性ピリジノン |
| US10836742B2 (en) | 2015-08-11 | 2020-11-17 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
| KR20180039117A (ko) | 2015-08-11 | 2018-04-17 | 네오메드 인스티튜트 | 아릴-치환된 디히드로퀴놀리논, 그의 제조법 및 제약으로서의 그의 용도 |
| JP6912039B2 (ja) | 2015-08-12 | 2021-07-28 | ネオメド インスティテュートＮｅｏｍｅｄ Ｉｎｓｔｉｔｕｔｅ | 置換ベンゾイミダゾール、それらの調製及び医薬品としてのそれらの使用 |
| WO2017066876A1 (en) | 2015-10-21 | 2017-04-27 | Neomed Institute | Substituted imidazopyridines, their preparation and their use as pharmaceuticals |
| WO2017127930A1 (en) | 2016-01-28 | 2017-08-03 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals |
| CN109071534B (zh) | 2016-04-15 | 2021-11-23 | 艾伯维公司 | 布罗莫结构域抑制剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4699909A (en) * | 1981-07-25 | 1987-10-13 | Dr. Karl Thomae Gmbh | Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones |
| DE3505609A1 (de) * | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| DE3511110A1 (de) * | 1985-03-27 | 1986-10-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3611343A1 (de) * | 1986-04-04 | 1987-10-08 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte benzimidazole, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte |
| DE3728244A1 (de) * | 1987-08-25 | 1989-03-09 | Thomae Gmbh Dr K | Neue (-)-benzimidazole, deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3734083A1 (de) * | 1987-10-08 | 1989-04-20 | Heumann Pharma Gmbh & Co | Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| DE3934436A1 (de) * | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CN1034934C (zh) * | 1990-06-19 | 1997-05-21 | 明治制果株式会社 | 血管紧张素ii拮抗性吡啶衍生物的制备方法 |
| GB9015764D0 (en) * | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| RU1836357C (ru) * | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами |
-
1992
- 1992-11-07 DE DE4237656A patent/DE4237656A1/de not_active Withdrawn
-
1993
- 1993-06-07 EP EP19930109121 patent/EP0574787A3/de not_active Withdrawn
- 1993-06-08 JP JP5137689A patent/JPH0665234A/ja active Pending
- 1993-06-08 SK SK577-93A patent/SK57793A3/sk unknown
- 1993-06-10 MX MX9303469A patent/MX9303469A/es unknown
- 1993-06-11 CZ CZ931144A patent/CZ114493A3/cs unknown
- 1993-06-11 PL PL29928493A patent/PL299284A1/xx unknown
- 1993-06-11 NO NO932146A patent/NO932146L/no unknown
- 1993-06-11 HU HU9301714A patent/HUT69712A/hu unknown
- 1993-06-11 US US08/075,247 patent/US5401738A/en not_active Expired - Fee Related
- 1993-06-11 AU AU41237/93A patent/AU4123793A/en not_active Abandoned
- 1993-06-11 CA CA002098243A patent/CA2098243A1/en not_active Abandoned
- 1993-06-11 HU HU9301713A patent/HU9301713D0/hu unknown
- 1993-06-12 CN CN93107011A patent/CN1082542A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CZ114493A3 (en) | 1994-01-19 |
| CN1082542A (zh) | 1994-02-23 |
| US5401738A (en) | 1995-03-28 |
| EP0574787A2 (de) | 1993-12-22 |
| HUT69712A (en) | 1995-09-28 |
| PL299284A1 (en) | 1994-01-24 |
| DE4237656A1 (de) | 1993-12-16 |
| EP0574787A3 (en) | 1994-06-22 |
| AU4123793A (en) | 1993-12-23 |
| HU9301713D0 (en) | 1993-09-28 |
| MX9303469A (es) | 1994-01-31 |
| CA2098243A1 (en) | 1993-12-14 |
| HU9301714D0 (en) | 1993-09-28 |
| JPH0665234A (ja) | 1994-03-08 |
| NO932146L (no) | 1993-12-14 |
| NO932146D0 (no) | 1993-06-11 |
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