SK4782002A3 - Lipidic vesicles, a method for the manufacture thereof pharmaceutical composition containing the same and use thereof - Google Patents
Lipidic vesicles, a method for the manufacture thereof pharmaceutical composition containing the same and use thereof Download PDFInfo
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- SK4782002A3 SK4782002A3 SK478-2002A SK4782002A SK4782002A3 SK 4782002 A3 SK4782002 A3 SK 4782002A3 SK 4782002 A SK4782002 A SK 4782002A SK 4782002 A3 SK4782002 A3 SK 4782002A3
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- CSONUCOCPOCMJG-UHFFFAOYSA-N n-tert-butyl-n-tetradecyl-3-(tetradecylamino)propanimidamide Chemical compound CCCCCCCCCCCCCCNCCC(=N)N(C(C)(C)C)CCCCCCCCCCCCCC CSONUCOCPOCMJG-UHFFFAOYSA-N 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- LUYQYZLEHLTPBH-UHFFFAOYSA-N perfluorobutanesulfonyl fluoride Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=O LUYQYZLEHLTPBH-UHFFFAOYSA-N 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000010837 receptor-mediated endocytosis Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 1
- 238000000856 sucrose gradient centrifugation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 101150047061 tag-72 gene Proteins 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000008299 viral mechanism Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/414,872 US6210708B1 (en) | 1996-05-08 | 1999-10-08 | Cationic virosomes as transfer system for genetic material |
| PCT/EP2000/009540 WO2001026628A1 (fr) | 1999-10-08 | 2000-09-29 | Virosomes dosper cationiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK4782002A3 true SK4782002A3 (en) | 2002-09-10 |
Family
ID=23643351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK478-2002A SK4782002A3 (en) | 1999-10-08 | 2000-09-29 | Lipidic vesicles, a method for the manufacture thereof pharmaceutical composition containing the same and use thereof |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1217990B1 (fr) |
| JP (1) | JP2003512306A (fr) |
| KR (1) | KR100869195B1 (fr) |
| AT (1) | ATE258428T1 (fr) |
| AU (1) | AU778399B2 (fr) |
| CA (1) | CA2388053A1 (fr) |
| CO (1) | CO5280052A1 (fr) |
| CZ (1) | CZ20021216A3 (fr) |
| DE (1) | DE60008006T2 (fr) |
| DK (1) | DK1217990T3 (fr) |
| ES (1) | ES2215073T3 (fr) |
| HU (1) | HUP0202809A2 (fr) |
| NO (1) | NO20021607L (fr) |
| PE (1) | PE20010703A1 (fr) |
| PL (1) | PL355231A1 (fr) |
| RU (1) | RU2002112224A (fr) |
| SK (1) | SK4782002A3 (fr) |
| TR (1) | TR200200930T2 (fr) |
| WO (1) | WO2001026628A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100488491C (zh) * | 2002-11-21 | 2009-05-20 | 派维翁生物技术有限公司 | 高效融合小泡,其制备方法和含有该小泡的药物组合物 |
| JP4497894B2 (ja) * | 2003-11-07 | 2010-07-07 | 明彦 河合 | 物質導入剤およびその製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL296382A1 (en) * | 1991-02-02 | 1993-11-02 | Nika Health Products Ltd Li Li | Artificial membrane beads containing functionally active peptides responsible for fusion as a drug administering system |
| DE19521412A1 (de) * | 1995-06-14 | 1996-12-19 | Boehringer Mannheim Gmbh | Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung |
| NZ332666A (en) * | 1996-05-08 | 2000-05-26 | Nika Health Products Ltd | Cationic virosomes having a positively charged lipid bilayer membrane with an integrated viral fusogenic peptide as genetic transfer systems for use in gene therapy |
| ATE340259T1 (de) * | 1996-07-16 | 2006-10-15 | Archibald James Mixson | Kationisches vehikel: dns komplexe und ihre verwendung in gentherapie |
-
2000
- 2000-09-29 CZ CZ20021216A patent/CZ20021216A3/cs unknown
- 2000-09-29 WO PCT/EP2000/009540 patent/WO2001026628A1/fr active IP Right Grant
- 2000-09-29 CA CA002388053A patent/CA2388053A1/fr not_active Abandoned
- 2000-09-29 JP JP2001529418A patent/JP2003512306A/ja active Pending
- 2000-09-29 HU HU0202809A patent/HUP0202809A2/hu unknown
- 2000-09-29 TR TR2002/00930T patent/TR200200930T2/xx unknown
- 2000-09-29 RU RU2002112224/15A patent/RU2002112224A/ru unknown
- 2000-09-29 KR KR1020027004325A patent/KR100869195B1/ko not_active IP Right Cessation
- 2000-09-29 EP EP00967824A patent/EP1217990B1/fr not_active Expired - Lifetime
- 2000-09-29 PL PL00355231A patent/PL355231A1/xx not_active IP Right Cessation
- 2000-09-29 DE DE60008006T patent/DE60008006T2/de not_active Expired - Fee Related
- 2000-09-29 ES ES00967824T patent/ES2215073T3/es not_active Expired - Lifetime
- 2000-09-29 AU AU77850/00A patent/AU778399B2/en not_active Ceased
- 2000-09-29 SK SK478-2002A patent/SK4782002A3/sk unknown
- 2000-09-29 AT AT00967824T patent/ATE258428T1/de not_active IP Right Cessation
- 2000-09-29 DK DK00967824T patent/DK1217990T3/da active
- 2000-10-06 PE PE2000001071A patent/PE20010703A1/es not_active Application Discontinuation
- 2000-10-06 CO CO00076243A patent/CO5280052A1/es not_active Application Discontinuation
-
2002
- 2002-04-05 NO NO20021607A patent/NO20021607L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL355231A1 (en) | 2004-04-05 |
| EP1217990B1 (fr) | 2004-01-28 |
| PE20010703A1 (es) | 2001-07-11 |
| DE60008006T2 (de) | 2004-09-09 |
| CZ20021216A3 (cs) | 2002-10-16 |
| WO2001026628A1 (fr) | 2001-04-19 |
| AU778399B2 (en) | 2004-12-02 |
| CA2388053A1 (fr) | 2001-04-19 |
| CO5280052A1 (es) | 2003-05-30 |
| NO20021607D0 (no) | 2002-04-05 |
| DK1217990T3 (da) | 2004-05-24 |
| JP2003512306A (ja) | 2003-04-02 |
| KR20020063872A (ko) | 2002-08-05 |
| TR200200930T2 (tr) | 2002-08-21 |
| EP1217990A1 (fr) | 2002-07-03 |
| NO20021607L (no) | 2002-06-07 |
| RU2002112224A (ru) | 2004-01-10 |
| AU7785000A (en) | 2001-04-23 |
| ES2215073T3 (es) | 2004-10-01 |
| HUP0202809A2 (hu) | 2002-12-28 |
| ATE258428T1 (de) | 2004-02-15 |
| KR100869195B1 (ko) | 2008-11-18 |
| DE60008006D1 (de) | 2004-03-04 |
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