SK4742001A3 - Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection - Google Patents
Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection Download PDFInfo
- Publication number
- SK4742001A3 SK4742001A3 SK474-2001A SK4742001A SK4742001A3 SK 4742001 A3 SK4742001 A3 SK 4742001A3 SK 4742001 A SK4742001 A SK 4742001A SK 4742001 A3 SK4742001 A3 SK 4742001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- effective amount
- interferon alpha
- represented
- Prior art date
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
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- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical compound OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- XYITYKDGJLHYPW-UHFFFAOYSA-M sodium 2-iodohippurate Chemical compound [Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1I XYITYKDGJLHYPW-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17405998A | 1998-10-16 | 1998-10-16 | |
| US09/348,534 US6277830B1 (en) | 1998-10-16 | 1999-07-07 | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
| PCT/US1999/021448 WO2000023454A1 (en) | 1998-10-16 | 1999-10-14 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK4742001A3 true SK4742001A3 (en) | 2001-11-06 |
Family
ID=26869824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK474-2001A SK4742001A3 (en) | 1998-10-16 | 1999-10-14 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1121369B1 (de) |
| JP (1) | JP2002527522A (de) |
| CN (1) | CN1330658A (de) |
| AT (1) | ATE284408T1 (de) |
| AU (1) | AU762395B2 (de) |
| BR (1) | BR9915546A (de) |
| CA (1) | CA2346447C (de) |
| CZ (1) | CZ20011130A3 (de) |
| DE (1) | DE69922529T2 (de) |
| ES (1) | ES2229820T3 (de) |
| HU (1) | HUP0200447A2 (de) |
| ID (1) | ID29187A (de) |
| IL (1) | IL142423A0 (de) |
| NO (1) | NO20011789L (de) |
| NZ (1) | NZ510811A (de) |
| PL (1) | PL347268A1 (de) |
| RU (1) | RU2001113268A (de) |
| SK (1) | SK4742001A3 (de) |
| TR (1) | TR200101085T2 (de) |
| WO (1) | WO2000023454A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001255495A1 (en) | 2000-04-20 | 2001-11-07 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| WO2004084796A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmasset Ltd. | Compounds for the treatment of flaviviridae infections |
| WO2005016370A1 (en) * | 2003-08-13 | 2005-02-24 | Howard J. Smith & Associates Pty Ltd | Method of treating viral infections |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| CA2606106A1 (en) | 2005-05-02 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| JPWO2009028573A1 (ja) | 2007-08-27 | 2010-12-09 | 国立大学法人名古屋大学 | 血液凝固障害におけるリバビリンの利用 |
| US20110045535A1 (en) | 2007-08-27 | 2011-02-24 | National University Corporation Nagoya University | Activator for Blood Coagulation Factor VII Promoter and Utilization of the Same |
| WO2011151667A1 (en) | 2010-06-02 | 2011-12-08 | Adbula Kurkayev | Antiviral compositions |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CA2811203C (en) | 2011-10-21 | 2015-05-05 | Abbvie Inc. | Methods for treating hcv |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| WO2018035380A1 (en) | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| CN107513055B (zh) * | 2017-08-11 | 2018-06-22 | 广东昊邦医药健康有限责任公司 | 一种利巴韦林衍生化合物及其药物组合物 |
| US20240325419A1 (en) | 2022-05-05 | 2024-10-03 | Abdula Kurkayev | Pharmaceutical composition for restoring physiological processes and cells of organism |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1482736A (en) * | 1974-03-18 | 1977-08-10 | Icn Pharmaceuticals | 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives |
| US4544741A (en) * | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
| US4925930A (en) * | 1988-11-02 | 1990-05-15 | Nucleic Acid Research Institute | Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates |
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| AU735438B2 (en) * | 1996-11-12 | 2001-07-05 | Medivir Ab | Nucleosides |
-
1999
- 1999-10-14 IL IL14242399A patent/IL142423A0/xx unknown
- 1999-10-14 ES ES99970662T patent/ES2229820T3/es not_active Expired - Lifetime
- 1999-10-14 AU AU11975/00A patent/AU762395B2/en not_active Ceased
- 1999-10-14 NZ NZ510811A patent/NZ510811A/xx unknown
- 1999-10-14 SK SK474-2001A patent/SK4742001A3/sk unknown
- 1999-10-14 BR BR9915546-0A patent/BR9915546A/pt not_active IP Right Cessation
- 1999-10-14 ID IDW20010844A patent/ID29187A/id unknown
- 1999-10-14 PL PL99347268A patent/PL347268A1/xx not_active Application Discontinuation
- 1999-10-14 AT AT99970662T patent/ATE284408T1/de not_active IP Right Cessation
- 1999-10-14 CN CN99814344A patent/CN1330658A/zh active Pending
- 1999-10-14 JP JP2000577180A patent/JP2002527522A/ja active Pending
- 1999-10-14 DE DE69922529T patent/DE69922529T2/de not_active Expired - Fee Related
- 1999-10-14 TR TR2001/01085T patent/TR200101085T2/xx unknown
- 1999-10-14 CZ CZ20011130A patent/CZ20011130A3/cs unknown
- 1999-10-14 HU HU0200447A patent/HUP0200447A2/hu unknown
- 1999-10-14 EP EP99970662A patent/EP1121369B1/de not_active Expired - Lifetime
- 1999-10-14 WO PCT/US1999/021448 patent/WO2000023454A1/en not_active Ceased
- 1999-10-14 RU RU2001113268/04A patent/RU2001113268A/ru not_active Application Discontinuation
- 1999-10-14 CA CA002346447A patent/CA2346447C/en not_active Expired - Fee Related
-
2001
- 2001-04-09 NO NO20011789A patent/NO20011789L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2229820T3 (es) | 2005-04-16 |
| JP2002527522A (ja) | 2002-08-27 |
| BR9915546A (pt) | 2001-08-14 |
| AU1197500A (en) | 2000-05-08 |
| IL142423A0 (en) | 2002-03-10 |
| EP1121369A1 (de) | 2001-08-08 |
| RU2001113268A (ru) | 2003-09-27 |
| TR200101085T2 (tr) | 2001-08-21 |
| NZ510811A (en) | 2003-06-30 |
| ID29187A (id) | 2001-08-09 |
| CN1330658A (zh) | 2002-01-09 |
| DE69922529D1 (de) | 2005-01-13 |
| NO20011789L (no) | 2001-06-11 |
| CA2346447C (en) | 2006-01-31 |
| AU762395B2 (en) | 2003-06-26 |
| ATE284408T1 (de) | 2004-12-15 |
| WO2000023454A1 (en) | 2000-04-27 |
| DE69922529T2 (de) | 2005-12-15 |
| CA2346447A1 (en) | 2000-04-27 |
| PL347268A1 (en) | 2002-03-25 |
| HUP0200447A2 (en) | 2002-06-29 |
| CZ20011130A3 (cs) | 2001-08-15 |
| EP1121369B1 (de) | 2004-12-08 |
| NO20011789D0 (no) | 2001-04-09 |
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