SK4272000A3 - The use of dolastatin-15 derivative in the treatment and prevention of rheumatoid arthritis - Google Patents

The use of dolastatin-15 derivative in the treatment and prevention of rheumatoid arthritis Download PDF

Info

Publication number
SK4272000A3
SK4272000A3 SK427-2000A SK4272000A SK4272000A3 SK 4272000 A3 SK4272000 A3 SK 4272000A3 SK 4272000 A SK4272000 A SK 4272000A SK 4272000 A3 SK4272000 A3 SK 4272000A3
Authority
SK
Slovakia
Prior art keywords
prolyl
tert
carbonyl
val
formula
Prior art date
Application number
SK427-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Teresa Barlozzari
Subhashis Banerjee
Andreas Haupt
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of SK4272000A3 publication Critical patent/SK4272000A3/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SK427-2000A 1997-10-06 1998-09-24 The use of dolastatin-15 derivative in the treatment and prevention of rheumatoid arthritis SK4272000A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/944,479 US6015790A (en) 1997-10-06 1997-10-06 Methods and compositions for treating rheumatoid arthritis
PCT/US1998/019841 WO1999017792A1 (en) 1997-10-06 1998-09-24 Methods and compositions for treating rheumatoid arthritis

Publications (1)

Publication Number Publication Date
SK4272000A3 true SK4272000A3 (en) 2001-02-12

Family

ID=25481479

Family Applications (1)

Application Number Title Priority Date Filing Date
SK427-2000A SK4272000A3 (en) 1997-10-06 1998-09-24 The use of dolastatin-15 derivative in the treatment and prevention of rheumatoid arthritis

Country Status (24)

Country Link
US (1) US6015790A (da)
EP (1) EP1021200B1 (da)
JP (1) JP2001518515A (da)
KR (1) KR20010081900A (da)
CN (1) CN1278734A (da)
AR (1) AR017298A1 (da)
AT (1) ATE212855T1 (da)
AU (2) AU748465B2 (da)
BG (1) BG104292A (da)
BR (1) BR9812875A (da)
CA (1) CA2305688A1 (da)
DE (1) DE69803792D1 (da)
DK (1) DK1021200T3 (da)
ES (1) ES2173626T3 (da)
HR (1) HRP20000265A2 (da)
HU (1) HUP0101715A3 (da)
IL (1) IL135167A0 (da)
NO (1) NO20001758L (da)
PL (1) PL339731A1 (da)
PT (1) PT1021200E (da)
SK (1) SK4272000A3 (da)
TR (1) TR200000903T2 (da)
WO (2) WO1999017792A1 (da)
ZA (1) ZA989036B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
KR100261114B1 (ko) * 1998-01-24 2000-07-01 박종헌 히스톤을 함유하는 류마티스 관절염 치료제 조성물
EP1214087A1 (en) * 1999-09-14 2002-06-19 Pfizer Products Inc. Combination treatment with il-1ra and compounds that inhibit il-1 processing and release
WO2001041789A1 (fr) * 1999-12-07 2001-06-14 Santen Pharmaceutical Co., Ltd. Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
JP3808772B2 (ja) 1999-12-24 2006-08-16 エフ．ホフマン−ラ ロシュ アーゲー カテプシンｋ阻害剤としてのニトリル誘導体
AU2007343454A1 (en) * 2007-01-09 2008-07-17 Bayer Schering Pharma Aktiengesellschaft Radiolabelling via fluorination of aziridines
WO2010147547A1 (en) * 2009-06-18 2010-12-23 Neobiotics Ab Novel peptide derivatives for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation
EP2944637B1 (en) * 2013-01-11 2020-02-19 FUJIFILM Corporation Nitrogen-containing heterocylic compound or salt thereof
KR102372512B1 (ko) * 2017-11-20 2022-03-10 가톨릭대학교 산학협력단 폴리감마글루탐산 및 메토트렉세이트를 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물
CN115281149A (zh) * 2021-05-12 2022-11-04 四川大学华西医院 一种临床前类风湿关节炎(Pre-RA)小鼠模型

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DK0934950T3 (da) * 1991-08-09 2002-07-29 Teikoku Hormone Mfg Co Ltd Tetrapeptidderivat
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
SG67935A1 (en) * 1992-12-16 1999-10-19 Basf Ag Novel peptides the preparation and use thereof
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5583153A (en) * 1994-10-06 1996-12-10 Regents Of The University Of California Use of taxol in the treatment of rheumatoid arthritis

Also Published As

Publication number Publication date
TR200000903T2 (tr) 2001-07-23
PL339731A1 (en) 2001-01-02
IL135167A0 (en) 2001-05-20
NO20001758D0 (no) 2000-04-05
CA2305688A1 (en) 1999-04-15
ATE212855T1 (de) 2002-02-15
US6015790A (en) 2000-01-18
ES2173626T3 (es) 2002-10-16
AU9502498A (en) 1999-04-27
DK1021200T3 (da) 2002-05-27
EP1021200A1 (en) 2000-07-26
JP2001518515A (ja) 2001-10-16
CN1278734A (zh) 2001-01-03
HUP0101715A2 (hu) 2001-11-28
AR017298A1 (es) 2001-09-05
AU748465B2 (en) 2002-06-06
BR9812875A (pt) 2000-08-08
EP1021200B1 (en) 2002-02-06
ZA989036B (en) 2000-04-05
KR20010081900A (ko) 2001-08-29
WO1999017709A2 (en) 1999-04-15
WO1999017792A1 (en) 1999-04-15
HUP0101715A3 (en) 2001-12-28
PT1021200E (pt) 2002-07-31
HRP20000265A2 (en) 2000-12-31
DE69803792D1 (de) 2002-03-21
BG104292A (en) 2000-12-29
AU9592698A (en) 1999-04-27
NO20001758L (no) 2000-06-05

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