SK37595A3 - N-(hydroxyethyl) butanediamine derivatives as renim inhibitors - Google Patents
N-(hydroxyethyl) butanediamine derivatives as renim inhibitors Download PDFInfo
- Publication number
- SK37595A3 SK37595A3 SK375-95A SK37595A SK37595A3 SK 37595 A3 SK37595 A3 SK 37595A3 SK 37595 A SK37595 A SK 37595A SK 37595 A3 SK37595 A3 SK 37595A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- cyclohexylmethyl
- dihydroxy
- methylhexyl
- butanediamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/19—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95125092A | 1992-09-25 | 1992-09-25 | |
PCT/CA1993/000379 WO1994007845A1 (en) | 1992-09-25 | 1993-09-15 | N-(hydroxyethyl)butanediamide derivatives as renin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SK37595A3 true SK37595A3 (en) | 1995-07-11 |
Family
ID=25491483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK375-95A SK37595A3 (en) | 1992-09-25 | 1993-09-15 | N-(hydroxyethyl) butanediamine derivatives as renim inhibitors |
Country Status (26)
Country | Link |
---|---|
US (3) | US5523315A (zh) |
EP (1) | EP0589446B1 (zh) |
JP (1) | JP3490441B2 (zh) |
KR (1) | KR950703519A (zh) |
CN (1) | CN1087625A (zh) |
AT (1) | ATE157646T1 (zh) |
AU (1) | AU677602B2 (zh) |
BG (1) | BG99541A (zh) |
BR (1) | BR9307111A (zh) |
CA (1) | CA2143301C (zh) |
CZ (1) | CZ74795A3 (zh) |
DE (1) | DE69313572T2 (zh) |
EE (1) | EE03082B1 (zh) |
FI (1) | FI951397A0 (zh) |
HU (2) | HUT70402A (zh) |
IL (1) | IL107093A (zh) |
LT (1) | LT3073B (zh) |
LV (1) | LV10944B (zh) |
MX (1) | MX9305912A (zh) |
NZ (1) | NZ255300A (zh) |
PL (1) | PL174487B1 (zh) |
RU (1) | RU95113446A (zh) |
SK (1) | SK37595A3 (zh) |
TW (1) | TW267153B (zh) |
WO (1) | WO1994007845A1 (zh) |
ZA (1) | ZA937080B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133405A (en) * | 1997-07-10 | 2000-10-17 | Hercules Incorporated | Polyalkanolamide tackifying resins for creping adhesives |
SE0000382D0 (sv) | 2000-02-07 | 2000-02-07 | Astrazeneca Ab | New process |
CN104510481A (zh) * | 2013-09-26 | 2015-04-15 | 温州市高德医疗器械有限公司 | 高血压三项酶抑制剂真空采血管及其制作方法 |
CN104292123B (zh) * | 2014-09-27 | 2015-12-02 | 张远强 | 苯基萘环的丁二酸酰胺衍生物、其制备方法及用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3159538A (en) * | 1962-05-08 | 1964-12-01 | Kuhlmann Ets | Anti-inflammatory therapeutic agent and process |
GB975370A (en) * | 1962-05-09 | 1964-11-18 | Gordon Owen Shipton | A new diamide and pharmaceutical preparations containing it |
US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
EP0278158A3 (en) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
US4877785A (en) * | 1987-10-01 | 1989-10-31 | G. D. Searle & Co. | Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents |
US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
EP0312283A3 (en) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa |
CA1329680C (en) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | N-heterocyclic alcohol derivatives |
US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
IL90822A0 (en) * | 1988-07-01 | 1990-01-18 | Searle & Co | Ethereal n-terminal aminodiol amino acid derivatives and pharmaceutical compositions containing them |
IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
US5374731A (en) * | 1989-09-12 | 1994-12-20 | Hoechst Aktiengesellschaft | Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof |
EP0438311A3 (en) | 1990-01-19 | 1992-07-01 | Merck & Co. Inc. | Di- and tripeptide renin inhibitors |
US5101073A (en) * | 1990-08-27 | 1992-03-31 | Rohm And Haas Company | Production of β-hydroxyalkylamides |
NZ255301A (en) * | 1992-09-25 | 1997-05-26 | Bio Mega Boehringer Ingelheim | N-(2-amino-2-oxoethyl)butanediamide derivatives, preparation and pharmaceutical compositions thereof |
-
1993
- 1993-09-15 BR BR9307111A patent/BR9307111A/pt not_active Application Discontinuation
- 1993-09-15 CA CA002143301A patent/CA2143301C/en not_active Expired - Fee Related
- 1993-09-15 PL PL93308179A patent/PL174487B1/pl unknown
- 1993-09-15 NZ NZ255300A patent/NZ255300A/en unknown
- 1993-09-15 JP JP50854194A patent/JP3490441B2/ja not_active Expired - Fee Related
- 1993-09-15 HU HU9500872A patent/HUT70402A/hu unknown
- 1993-09-15 WO PCT/CA1993/000379 patent/WO1994007845A1/en not_active Application Discontinuation
- 1993-09-15 CZ CZ95747A patent/CZ74795A3/cs unknown
- 1993-09-15 SK SK375-95A patent/SK37595A3/sk unknown
- 1993-09-15 AU AU49402/93A patent/AU677602B2/en not_active Ceased
- 1993-09-15 KR KR1019950701199A patent/KR950703519A/ko not_active Application Discontinuation
- 1993-09-15 RU RU95113446/04A patent/RU95113446A/ru unknown
- 1993-09-20 US US08/123,954 patent/US5523315A/en not_active Expired - Lifetime
- 1993-09-23 DE DE69313572T patent/DE69313572T2/de not_active Expired - Lifetime
- 1993-09-23 EP EP93115327A patent/EP0589446B1/en not_active Expired - Lifetime
- 1993-09-23 LT LTIP1093A patent/LT3073B/lt not_active IP Right Cessation
- 1993-09-23 AT AT93115327T patent/ATE157646T1/de not_active IP Right Cessation
- 1993-09-23 IL IL107093A patent/IL107093A/xx not_active IP Right Cessation
- 1993-09-24 ZA ZA937080A patent/ZA937080B/xx unknown
- 1993-09-24 TW TW082107870A patent/TW267153B/zh active
- 1993-09-24 MX MX9305912A patent/MX9305912A/es not_active IP Right Cessation
- 1993-09-25 CN CN93117984A patent/CN1087625A/zh active Pending
-
1994
- 1994-11-23 EE EE9400395A patent/EE03082B1/xx unknown
-
1995
- 1995-03-24 FI FI951397A patent/FI951397A0/fi not_active Application Discontinuation
- 1995-04-03 BG BG99541A patent/BG99541A/bg unknown
- 1995-04-25 LV LVP-95-108A patent/LV10944B/en unknown
- 1995-05-01 US US08/432,503 patent/US5554634A/en not_active Expired - Lifetime
- 1995-05-01 US US08/432,409 patent/US5565476A/en not_active Expired - Lifetime
- 1995-06-23 HU HU95P/P00426P patent/HU211531A9/hu unknown
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