SK287901B6 - Use of Ecteinascidin 743 for preparation of medicament for effective antitumor treatment - Google Patents
Use of Ecteinascidin 743 for preparation of medicament for effective antitumor treatment Download PDFInfo
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- SK287901B6 SK287901B6 SK549-2003A SK5492003A SK287901B6 SK 287901 B6 SK287901 B6 SK 287901B6 SK 5492003 A SK5492003 A SK 5492003A SK 287901 B6 SK287901 B6 SK 287901B6
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- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
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- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
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- 238000011275 oncology therapy Methods 0.000 description 1
- 229940127084 other anti-cancer agent Drugs 0.000 description 1
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
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- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
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- NWWZPOKUUAIXIW-UHFFFAOYSA-N thiamethoxam Chemical compound O=N(=O)N=C1N(C)COCN1CC1=CN=C(Cl)S1 NWWZPOKUUAIXIW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24623300P | 2000-11-06 | 2000-11-06 | |
| US24809500P | 2000-11-13 | 2000-11-13 | |
| US34598201P | 2001-10-19 | 2001-10-19 | |
| PCT/GB2001/004902 WO2002036135A2 (fr) | 2000-11-06 | 2001-11-06 | Traitements anti-tumeur efficaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK5492003A3 SK5492003A3 (en) | 2004-03-02 |
| SK287901B6 true SK287901B6 (sk) | 2012-03-02 |
Family
ID=27399908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK549-2003A SK287901B6 (sk) | 2000-11-06 | 2001-11-06 | Use of Ecteinascidin 743 for preparation of medicament for effective antitumor treatment |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20040108086A1 (fr) |
| EP (1) | EP1365808B1 (fr) |
| JP (2) | JP4391083B2 (fr) |
| KR (1) | KR100718946B1 (fr) |
| CN (1) | CN100374162C (fr) |
| AT (1) | ATE495793T1 (fr) |
| AU (2) | AU1249902A (fr) |
| BG (1) | BG107843A (fr) |
| BR (1) | BR0115162A (fr) |
| CA (1) | CA2428160C (fr) |
| CY (1) | CY1112361T1 (fr) |
| CZ (1) | CZ20031327A3 (fr) |
| DE (1) | DE60143911D1 (fr) |
| DK (1) | DK1365808T3 (fr) |
| EA (1) | EA005564B1 (fr) |
| HK (1) | HK1060067A1 (fr) |
| HU (1) | HUP0400648A3 (fr) |
| IL (1) | IL155781A0 (fr) |
| MX (1) | MXPA03003975A (fr) |
| NO (1) | NO329981B1 (fr) |
| NZ (1) | NZ525730A (fr) |
| PL (1) | PL361389A1 (fr) |
| PT (1) | PT1365808E (fr) |
| SK (1) | SK287901B6 (fr) |
| WO (1) | WO2002036135A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US20040108086A1 (en) * | 2000-11-06 | 2004-06-10 | Naoto Takahashi | Effective antitumor treatments |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| EP1435988A4 (fr) * | 2001-10-19 | 2008-01-09 | Pharmamar Sa | Utilisation amelioree de compose anti-tumoral dans le traitement des cancers |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| ES2314470T3 (es) | 2003-11-13 | 2009-03-16 | Pharma Mar, S.A.U. | Combinacion de et-743 con un profarmaco de 5-fluorouracilo para el tratamiento del cancer. |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| US20080255132A1 (en) * | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
| WO2006005602A2 (fr) * | 2004-07-09 | 2006-01-19 | Pharma Mar, S.A. | Marqueurs moleculaires de pronostic |
| CN101068596A (zh) * | 2004-09-29 | 2007-11-07 | 法马马私人股份有限公司 | 艾可特耐思地作抗炎药 |
| EP1827500B1 (fr) * | 2004-10-26 | 2009-05-06 | Pharma Mar S.A., Sociedad Unipersonal | Doxorubicine liposomiale pegylee en combinaison avec l' ecteinescidine 743 |
| PT1658848E (pt) * | 2004-10-29 | 2007-11-05 | Pharma Mar Sa | Formulações contendo ecteinascidina e um dissacarídeo |
| GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| WO2007062413A2 (fr) * | 2005-11-25 | 2007-05-31 | University Of Medicine And Dentistry Of New Jersey | Utilisation d'inhibiteurs du parp-1 |
| AU2008313634A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Prognostic molecular markers for ET-743 treatment |
| KR20170096065A (ko) * | 2010-11-12 | 2017-08-23 | 파르마 마르 에스.에이. | 항종양 알칼로이드를 이용한 병용요법 |
| GB201217439D0 (en) * | 2012-09-28 | 2012-11-14 | Topotarget As | Combination therapy |
| WO2014165818A2 (fr) | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions et méthodes de prévention et de traitement du cancer de la prostate |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| CN109276719A (zh) * | 2018-11-01 | 2019-01-29 | 中山万汉制药有限公司 | 含有奥利司他纳米粒与蛋白激酶抑制剂的组合物 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| DE3635711A1 (de) * | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| JP4562815B2 (ja) * | 1997-05-21 | 2010-10-13 | ジェネンテック， インコーポレイテッド | トロンボポエチンの新規な投与 |
| KR100603219B1 (ko) * | 1998-04-06 | 2006-07-20 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 반합성 엑테이나시딘 |
| BR9910419A (pt) * | 1998-05-11 | 2001-01-09 | Pharma Mar Sa | Etm-305, etm-204, etm-775, substancialmente puros, processos para tratar leucemia de mamìferos, para tratar carcinoma de pulmão de mamìferos, para tratar adenocarcinoma de cólon de mamìferos, e para tratar melanoma maligno de mamìferos, composição farmacêutica, e, processo para testar o metabolismo citocromo humano cyp3a4 de ecteinascidina 743 |
| JP2000081438A (ja) * | 1998-06-25 | 2000-03-21 | Sekisui Chem Co Ltd | 被験者の癌化学療法による免疫機能低下の測定方法 |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| US7247892B2 (en) * | 2000-04-24 | 2007-07-24 | Taylor Geoff W | Imaging array utilizing thyristor-based pixel elements |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| CA2418320A1 (fr) * | 2000-08-11 | 2002-02-21 | City Of Hope | Agent anti neoplasique et-743 inhibant la trans-activation par sxr |
| US20040108086A1 (en) * | 2000-11-06 | 2004-06-10 | Naoto Takahashi | Effective antitumor treatments |
| US6770653B2 (en) * | 2001-03-06 | 2004-08-03 | Bristol-Myers Squibb Company | Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin |
| JP4391038B2 (ja) * | 2001-05-10 | 2009-12-24 | パナソニック株式会社 | 電気炊飯器 |
| EP1435988A4 (fr) * | 2001-10-19 | 2008-01-09 | Pharmamar Sa | Utilisation amelioree de compose anti-tumoral dans le traitement des cancers |
| US20040019027A1 (en) * | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| ES2314470T3 (es) * | 2003-11-13 | 2009-03-16 | Pharma Mar, S.A.U. | Combinacion de et-743 con un profarmaco de 5-fluorouracilo para el tratamiento del cancer. |
| US20080255132A1 (en) * | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| WO2006005602A2 (fr) * | 2004-07-09 | 2006-01-19 | Pharma Mar, S.A. | Marqueurs moleculaires de pronostic |
| CN101068596A (zh) * | 2004-09-29 | 2007-11-07 | 法马马私人股份有限公司 | 艾可特耐思地作抗炎药 |
| EP1827500B1 (fr) * | 2004-10-26 | 2009-05-06 | Pharma Mar S.A., Sociedad Unipersonal | Doxorubicine liposomiale pegylee en combinaison avec l' ecteinescidine 743 |
| PT1658848E (pt) * | 2004-10-29 | 2007-11-05 | Pharma Mar Sa | Formulações contendo ecteinascidina e um dissacarídeo |
| WO2007062413A2 (fr) * | 2005-11-25 | 2007-05-31 | University Of Medicine And Dentistry Of New Jersey | Utilisation d'inhibiteurs du parp-1 |
| JP2009536956A (ja) * | 2006-05-12 | 2009-10-22 | ファルマ・マール・ソシエダード・アノニマ | 抗癌治療法 |
-
2001
- 2001-11-06 US US10/416,086 patent/US20040108086A1/en not_active Abandoned
- 2001-11-06 MX MXPA03003975A patent/MXPA03003975A/es active IP Right Grant
- 2001-11-06 SK SK549-2003A patent/SK287901B6/sk not_active IP Right Cessation
- 2001-11-06 AU AU1249902A patent/AU1249902A/xx active Pending
- 2001-11-06 WO PCT/GB2001/004902 patent/WO2002036135A2/fr active IP Right Grant
- 2001-11-06 AU AU2002212499A patent/AU2002212499B2/en not_active Ceased
- 2001-11-06 DK DK01980710.6T patent/DK1365808T3/da active
- 2001-11-06 KR KR1020037006228A patent/KR100718946B1/ko not_active IP Right Cessation
- 2001-11-06 CA CA002428160A patent/CA2428160C/fr not_active Expired - Fee Related
- 2001-11-06 AT AT01980710T patent/ATE495793T1/de active
- 2001-11-06 EP EP01980710A patent/EP1365808B1/fr not_active Revoked
- 2001-11-06 NZ NZ525730A patent/NZ525730A/xx not_active IP Right Cessation
- 2001-11-06 IL IL15578101A patent/IL155781A0/xx unknown
- 2001-11-06 PL PL01361389A patent/PL361389A1/xx not_active Application Discontinuation
- 2001-11-06 BR BR0115162-2A patent/BR0115162A/pt not_active IP Right Cessation
- 2001-11-06 CN CNB018218032A patent/CN100374162C/zh not_active Expired - Fee Related
- 2001-11-06 JP JP2002538946A patent/JP4391083B2/ja not_active Expired - Fee Related
- 2001-11-06 PT PT01980710T patent/PT1365808E/pt unknown
- 2001-11-06 HU HU0400648A patent/HUP0400648A3/hu unknown
- 2001-11-06 CZ CZ20031327A patent/CZ20031327A3/cs unknown
- 2001-11-06 DE DE60143911T patent/DE60143911D1/de not_active Expired - Lifetime
- 2001-11-06 EA EA200300544A patent/EA005564B1/ru not_active IP Right Cessation
-
2003
- 2003-05-06 NO NO20032027A patent/NO329981B1/no not_active IP Right Cessation
- 2003-05-23 BG BG107843A patent/BG107843A/bg unknown
-
2004
- 2004-05-04 HK HK04103120.3A patent/HK1060067A1/xx not_active IP Right Cessation
-
2009
- 2009-02-27 JP JP2009046557A patent/JP2009114212A/ja active Pending
- 2009-09-02 US US12/552,347 patent/US20090324744A1/en not_active Abandoned
-
2011
- 2011-04-18 CY CY20111100397T patent/CY1112361T1/el unknown
- 2011-12-30 US US13/341,262 patent/US20120107417A1/en not_active Abandoned
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20120112 |