SK287828B6 - 5-Halo-tryptamine derivatives used as ligands of 5-HT6 and/or 5-HT7 serotonin receptors - Google Patents
5-Halo-tryptamine derivatives used as ligands of 5-HT6 and/or 5-HT7 serotonin receptors Download PDFInfo
- Publication number
- SK287828B6 SK287828B6 SK38-2004A SK382004A SK287828B6 SK 287828 B6 SK287828 B6 SK 287828B6 SK 382004 A SK382004 A SK 382004A SK 287828 B6 SK287828 B6 SK 287828B6
- Authority
- SK
- Slovakia
- Prior art keywords
- use according
- formula
- disease
- compounds
- useful
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000356A ITRM20010356A1 (it) | 2001-06-21 | 2001-06-21 | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
PCT/IT2002/000398 WO2003000252A1 (en) | 2001-06-21 | 2002-06-17 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
SK382004A3 SK382004A3 (en) | 2004-05-04 |
SK287828B6 true SK287828B6 (sk) | 2011-11-04 |
Family
ID=11455609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK38-2004A SK287828B6 (sk) | 2001-06-21 | 2002-06-17 | 5-Halo-tryptamine derivatives used as ligands of 5-HT6 and/or 5-HT7 serotonin receptors |
Country Status (22)
Country | Link |
---|---|
US (1) | US7098233B2 (xx) |
EP (1) | EP1404317B1 (xx) |
JP (2) | JP4683839B2 (xx) |
KR (1) | KR100885308B1 (xx) |
CN (1) | CN100482223C (xx) |
AT (1) | ATE416767T1 (xx) |
AU (1) | AU2002317482B2 (xx) |
BR (1) | BR0210538A (xx) |
CA (1) | CA2455296C (xx) |
CY (1) | CY1108879T1 (xx) |
CZ (1) | CZ20033314A3 (xx) |
DE (1) | DE60230270D1 (xx) |
DK (1) | DK1404317T3 (xx) |
ES (1) | ES2319107T3 (xx) |
HK (1) | HK1068792A1 (xx) |
HU (1) | HUP0400250A3 (xx) |
IT (1) | ITRM20010356A1 (xx) |
MX (1) | MXPA03011510A (xx) |
PL (1) | PL367618A1 (xx) |
PT (1) | PT1404317E (xx) |
SK (1) | SK287828B6 (xx) |
WO (1) | WO2003000252A1 (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0308696B8 (pt) * | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
WO2005012254A1 (en) | 2003-07-22 | 2005-02-10 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto |
US8086315B2 (en) | 2004-02-12 | 2011-12-27 | Asap Medical, Inc. | Cardiac stimulation apparatus and method for the control of hypertension |
WO2005079845A1 (ja) | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
EP1852129A4 (en) * | 2005-02-08 | 2009-07-15 | Astellas Pharma Inc | REMEDIES FOR IRRITATION SYNDROME |
KR20080044273A (ko) * | 2005-08-08 | 2008-05-20 | 아스텔라스세이야쿠 가부시키가이샤 | 아실구아니딘 유도체 또는 그의 염 |
WO2007046112A1 (en) * | 2005-10-19 | 2007-04-26 | Suven Life Sciences Inc. | Arylthioether tryptamine derivatives as functional 5-ht6 ligands |
WO2007097276A1 (ja) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | ピロール誘導体またはその塩 |
US20100041672A1 (en) * | 2007-03-21 | 2010-02-18 | Glaxo Group Limited | Use of quinoline derivatives in the treatment of pain and irritable bowel syndrome |
WO2009049030A1 (en) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
CA2842455A1 (en) * | 2011-08-05 | 2013-02-14 | Sucampo Ag | Method for treating schizophrenia |
CN102816103B (zh) * | 2012-08-20 | 2014-05-07 | 冉瑞琼 | 硫化天冬氨酸修饰的退黑素衍生物及其应用 |
US9008769B2 (en) | 2012-12-21 | 2015-04-14 | Backbeat Medical, Inc. | Methods and systems for lowering blood pressure through reduction of ventricle filling |
US9370662B2 (en) | 2013-12-19 | 2016-06-21 | Backbeat Medical, Inc. | Methods and systems for controlling blood pressure by controlling atrial pressure |
CN104529865B (zh) * | 2014-12-12 | 2017-02-01 | 广东东阳光药业有限公司 | 苄胺类衍生物及其在药物上的应用 |
MX2017016413A (es) | 2015-06-12 | 2018-08-01 | Axovant Sciences Gmbh | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem. |
MX2018000465A (es) | 2015-07-15 | 2018-09-17 | Axovant Sciences Gmbh | Derivados de diaril y arilheteroaril urea como moduladores del receptor de serotonina 5-ht2a útiles para la profilaxis y el tratamiento de alucinaciones asociadas con una enfermedad neurodegenerativa. |
US10342982B2 (en) | 2015-09-11 | 2019-07-09 | Backbeat Medical, Inc. | Methods and systems for treating cardiac malfunction |
US10485658B2 (en) | 2016-04-22 | 2019-11-26 | Backbeat Medical, Inc. | Methods and systems for controlling blood pressure |
CN108926565A (zh) * | 2017-05-26 | 2018-12-04 | 中国科学院上海生命科学研究院 | 五羟色胺受体亚型6小分子激活剂及拮抗剂在防治阿尔茨海默症中的应用 |
CA3148256A1 (en) * | 2018-06-21 | 2019-12-26 | Robert John Petcavich | Method of inducing dendritic and synaptic genesis in neurodegenerative chronic diseases |
MX2022014605A (es) | 2020-05-19 | 2022-12-16 | Cybin Irl Ltd | Derivados de triptamina deuterada y metodos de uso. |
WO2022061196A1 (en) * | 2020-09-18 | 2022-03-24 | Mydecine Innovations Group Inc. | Novel formulations of psilocybin and psilocin compounds as serotonin agonists in combination with 3,4 methylenedioxymethamphetamine (mdma) |
WO2023018480A1 (en) * | 2021-08-09 | 2023-02-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Selective psychedelic compounds |
CA3238440A1 (en) * | 2021-12-30 | 2023-07-06 | Atai Therapeutics, Inc. | Dimethyltryptamine analogues as nitric oxide delivery drugs |
CN114573578B (zh) * | 2022-02-16 | 2023-11-17 | 烟台宁远药业有限公司 | 一种烷基取代氮杂吲哚的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US2825734A (en) * | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
GB966562A (en) * | 1961-04-06 | 1964-08-12 | Parke Davis & Co | Amine compounds and means of producing the same |
FR2315277A1 (fr) * | 1975-06-25 | 1977-01-21 | Anvar | Nouveaux derives pentacycliques, leur preparation et les compositions qui les contiennent |
US4428877A (en) * | 1978-07-12 | 1984-01-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Cis-10-bromo-E-homoeburnanes |
GB8531612D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
US5300645A (en) * | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
FR2712591B1 (fr) * | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
US5688807A (en) * | 1994-03-11 | 1997-11-18 | Eli Lilly And Company | Method for treating 5HT2B receptor related conditions |
US5504101A (en) * | 1994-05-06 | 1996-04-02 | Allelix Biopharmaceuticals, Inc. | 5-HT-1D receptor ligands |
EP0937715B1 (en) * | 1996-06-28 | 2005-06-01 | Meiji Seika Kaisha Ltd. | Tetrahydrobenzindole compounds |
US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
ATE319683T1 (de) | 1998-12-11 | 2006-03-15 | Univ Virginia Commonwealth | Selektive 5-ht 6-rezeptor-liganden |
US6403808B1 (en) * | 1999-12-10 | 2002-06-11 | Virginia Commonwealth University | Selective 5-HT6 receptor ligands |
MXPA01010655A (es) | 1999-04-21 | 2002-11-04 | Allelix Biopharma | Compuestos de piperidin-indol que tienen afinidad por 5-ht6. |
CA2382247C (en) | 1999-08-12 | 2010-09-28 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
WO2004041781A1 (en) * | 2002-11-07 | 2004-05-21 | Suven Life Sciences Limited | Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones |
-
2001
- 2001-06-21 IT IT2001RM000356A patent/ITRM20010356A1/it unknown
-
2002
- 2002-06-17 JP JP2003506898A patent/JP4683839B2/ja not_active Expired - Fee Related
- 2002-06-17 PL PL02367618A patent/PL367618A1/xx not_active IP Right Cessation
- 2002-06-17 ES ES02745793T patent/ES2319107T3/es not_active Expired - Lifetime
- 2002-06-17 MX MXPA03011510A patent/MXPA03011510A/es active IP Right Grant
- 2002-06-17 WO PCT/IT2002/000398 patent/WO2003000252A1/en active Application Filing
- 2002-06-17 BR BR0210538-1A patent/BR0210538A/pt not_active Application Discontinuation
- 2002-06-17 SK SK38-2004A patent/SK287828B6/sk not_active IP Right Cessation
- 2002-06-17 HU HU0400250A patent/HUP0400250A3/hu unknown
- 2002-06-17 US US10/481,433 patent/US7098233B2/en not_active Expired - Fee Related
- 2002-06-17 AU AU2002317482A patent/AU2002317482B2/en not_active Ceased
- 2002-06-17 CA CA2455296A patent/CA2455296C/en not_active Expired - Fee Related
- 2002-06-17 PT PT02745793T patent/PT1404317E/pt unknown
- 2002-06-17 AT AT02745793T patent/ATE416767T1/de active
- 2002-06-17 EP EP02745793A patent/EP1404317B1/en not_active Expired - Lifetime
- 2002-06-17 DK DK02745793T patent/DK1404317T3/da active
- 2002-06-17 DE DE60230270T patent/DE60230270D1/de not_active Expired - Lifetime
- 2002-06-17 CZ CZ20033314A patent/CZ20033314A3/cs unknown
- 2002-06-17 KR KR1020037016564A patent/KR100885308B1/ko not_active IP Right Cessation
- 2002-06-17 CN CNB02814337XA patent/CN100482223C/zh not_active Expired - Fee Related
-
2005
- 2005-02-16 HK HK05101226.9A patent/HK1068792A1/xx not_active IP Right Cessation
-
2009
- 2009-03-06 CY CY20091100260T patent/CY1108879T1/el unknown
-
2010
- 2010-09-13 JP JP2010204733A patent/JP2011016835A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MXPA03011510A (es) | 2004-03-18 |
CN1535146A (zh) | 2004-10-06 |
US20040235899A1 (en) | 2004-11-25 |
JP4683839B2 (ja) | 2011-05-18 |
PL367618A1 (en) | 2005-03-07 |
ES2319107T3 (es) | 2009-05-04 |
HUP0400250A3 (en) | 2008-03-28 |
KR20040032113A (ko) | 2004-04-14 |
CY1108879T1 (el) | 2014-07-02 |
ATE416767T1 (de) | 2008-12-15 |
CA2455296A1 (en) | 2003-01-03 |
ITRM20010356A0 (it) | 2001-06-21 |
CN100482223C (zh) | 2009-04-29 |
DE60230270D1 (de) | 2009-01-22 |
EP1404317A1 (en) | 2004-04-07 |
WO2003000252A1 (en) | 2003-01-03 |
CZ20033314A3 (cs) | 2004-08-18 |
ITRM20010356A1 (it) | 2002-12-23 |
HUP0400250A2 (hu) | 2004-08-30 |
JP2004534816A (ja) | 2004-11-18 |
BR0210538A (pt) | 2004-06-22 |
KR100885308B1 (ko) | 2009-02-24 |
AU2002317482B2 (en) | 2007-08-16 |
CA2455296C (en) | 2010-08-17 |
SK382004A3 (en) | 2004-05-04 |
DK1404317T3 (da) | 2009-02-23 |
JP2011016835A (ja) | 2011-01-27 |
HK1068792A1 (en) | 2005-05-06 |
US7098233B2 (en) | 2006-08-29 |
EP1404317B1 (en) | 2008-12-10 |
PT1404317E (pt) | 2009-02-23 |
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