SK287108B6 - N-Deacetyltiokolchicínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

N-Deacetyltiokolchicínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK287108B6
SK287108B6 SK1310-2002A SK13102002A SK287108B6 SK 287108 B6 SK287108 B6 SK 287108B6 SK 13102002 A SK13102002 A SK 13102002A SK 287108 B6 SK287108 B6 SK 287108B6
Authority
SK
Slovakia
Prior art keywords
deacetylthiocolchicine
compounds
mmol
mol
formula
Prior art date
Application number
SK1310-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK13102002A3 (sk
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena S. P. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S. P. A. filed Critical Indena S. P. A.
Publication of SK13102002A3 publication Critical patent/SK13102002A3/sk
Publication of SK287108B6 publication Critical patent/SK287108B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
SK1310-2002A 2000-03-17 2001-03-12 N-Deacetyltiokolchicínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie SK287108B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000554A IT1318401B1 (it) 2000-03-17 2000-03-17 Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
PCT/EP2001/002739 WO2001068597A1 (en) 2000-03-17 2001-03-12 N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
SK13102002A3 SK13102002A3 (sk) 2002-12-03
SK287108B6 true SK287108B6 (sk) 2009-12-07

Family

ID=11444502

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1310-2002A SK287108B6 (sk) 2000-03-17 2001-03-12 N-Deacetyltiokolchicínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (22)

Country Link
US (1) US6627774B2 (ko)
EP (1) EP1263719B1 (ko)
JP (1) JP4614608B2 (ko)
KR (1) KR100761577B1 (ko)
CN (1) CN1169788C (ko)
AU (2) AU2001248341B2 (ko)
CA (1) CA2403110C (ko)
CZ (1) CZ303386B6 (ko)
DE (1) DE60139306D1 (ko)
DK (1) DK1263719T3 (ko)
ES (1) ES2327386T3 (ko)
HK (1) HK1052168A1 (ko)
HU (1) HU228790B1 (ko)
IL (2) IL151715A0 (ko)
IT (1) IT1318401B1 (ko)
NO (1) NO329428B1 (ko)
PL (1) PL201575B1 (ko)
PT (1) PT1263719E (ko)
RU (1) RU2257379C2 (ko)
SI (1) SI1263719T1 (ko)
SK (1) SK287108B6 (ko)
WO (1) WO2001068597A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20040164A1 (it) 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
KR101914254B1 (ko) * 2005-02-18 2018-11-02 아브락시스 바이오사이언스, 엘엘씨 치료제의 조합 및 투여 방식, 및 조합 요법
EP3345632A1 (en) * 2005-02-18 2018-07-11 Abraxis BioScience, LLC Drugs with improved hydrophobicity for incorporation in medical devices
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
WO2008027055A1 (en) * 2006-08-31 2008-03-06 Abraxis Bioscience, Llc Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
CA2755121A1 (en) * 2009-03-13 2010-09-16 Neil P. Desai Combination therapy with thiocolchicine derivatives
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1359637A (fr) * 1962-10-29 1964-04-30 Roussel Uclaf Dérivés de la cochicine et de la thiocolchicine et procédé de préparation
US4533675A (en) * 1984-04-17 1985-08-06 The United States Of America As Represented By The Department Of Health And Human Services Carbamates of colchicine for treatment of gout
DE68927479T2 (de) * 1988-05-02 1997-04-03 Phanos Tech Inc Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen
US5433675A (en) * 1993-11-29 1995-07-18 Excelermatic Inc. Traction roller transmission
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono
IT1283110B1 (it) * 1996-06-07 1998-04-07 Indena Spa Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Also Published As

Publication number Publication date
CZ303386B6 (cs) 2012-08-29
RU2257379C2 (ru) 2005-07-27
SK13102002A3 (sk) 2002-12-03
PL357375A1 (en) 2004-07-26
ES2327386T3 (es) 2009-10-29
NO20024354L (no) 2002-09-12
CN1418190A (zh) 2003-05-14
HU228790B1 (en) 2013-05-28
US20030055111A1 (en) 2003-03-20
AU2001248341B2 (en) 2005-01-27
AU4834101A (en) 2001-09-24
ITMI20000554A1 (it) 2001-09-17
KR20020091123A (ko) 2002-12-05
HUP0300557A2 (hu) 2003-07-28
DK1263719T3 (da) 2009-11-16
HUP0300557A3 (en) 2004-08-30
KR100761577B1 (ko) 2007-10-04
CA2403110A1 (en) 2001-09-20
PT1263719E (pt) 2009-08-20
JP2003527371A (ja) 2003-09-16
EP1263719B1 (en) 2009-07-22
IT1318401B1 (it) 2003-08-25
NO20024354D0 (no) 2002-09-12
DE60139306D1 (de) 2009-09-03
WO2001068597A1 (en) 2001-09-20
ITMI20000554A0 (it) 2000-03-17
RU2002124524A (ru) 2004-03-20
CN1169788C (zh) 2004-10-06
JP4614608B2 (ja) 2011-01-19
PL201575B1 (pl) 2009-04-30
NO329428B1 (no) 2010-10-18
US6627774B2 (en) 2003-09-30
CA2403110C (en) 2009-12-15
SI1263719T1 (sl) 2009-10-31
IL151715A (en) 2007-12-03
EP1263719A1 (en) 2002-12-11
IL151715A0 (en) 2003-04-10
HK1052168A1 (en) 2003-09-05

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Legal Events

Date Code Title Description
MK4A Expiry of patent

Expiry date: 20210312