SK285963B6 - Kit obsahujúci estrogénové a progestínové dávkovacie jednotky a použitie estrogénu a antiprogestínu, prípadne progestínu, alebo použitie progestínu aantiprogestínu na prípravu liečiva - Google Patents

Kit obsahujúci estrogénové a progestínové dávkovacie jednotky a použitie estrogénu a antiprogestínu, prípadne progestínu, alebo použitie progestínu aantiprogestínu na prípravu liečiva Download PDF

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Publication number
SK285963B6
SK285963B6 SK1046-94A SK104694A SK285963B6 SK 285963 B6 SK285963 B6 SK 285963B6 SK 104694 A SK104694 A SK 104694A SK 285963 B6 SK285963 B6 SK 285963B6
Authority
SK
Slovakia
Prior art keywords
progestin
antiprogestin
estrogen
dose
effective
Prior art date
Application number
SK1046-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK104694A3 (en
Inventor
Gary D. Hodgen
Krzysztof Chwalisz
Original Assignee
Eastern Virginia Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastern Virginia Medical School filed Critical Eastern Virginia Medical School
Publication of SK104694A3 publication Critical patent/SK104694A3/sk
Publication of SK285963B6 publication Critical patent/SK285963B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
SK1046-94A 1992-03-02 1993-03-02 Kit obsahujúci estrogénové a progestínové dávkovacie jednotky a použitie estrogénu a antiprogestínu, prípadne progestínu, alebo použitie progestínu aantiprogestínu na prípravu liečiva SK285963B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84305892A 1992-03-02 1992-03-02
PCT/US1993/001931 WO1993017686A1 (fr) 1992-03-02 1993-03-02 Procede par ×strogene/progesterone/antiprogesterone, kit pour contraception orale et regulation des regles
CN93102182A CN1090481C (zh) 1992-03-02 1993-03-02 雌激素/孕激素/抗孕激素的应用,其组合物和药盒

Publications (2)

Publication Number Publication Date
SK104694A3 SK104694A3 (en) 1996-01-10
SK285963B6 true SK285963B6 (sk) 2007-12-06

Family

ID=25743002

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1046-94A SK285963B6 (sk) 1992-03-02 1993-03-02 Kit obsahujúci estrogénové a progestínové dávkovacie jednotky a použitie estrogénu a antiprogestínu, prípadne progestínu, alebo použitie progestínu aantiprogestínu na prípravu liečiva

Country Status (16)

Country Link
US (1) US7538099B1 (fr)
EP (1) EP0630246B1 (fr)
JP (1) JP4152431B2 (fr)
CN (1) CN1090481C (fr)
AU (1) AU678150B2 (fr)
BR (1) BR9306005A (fr)
CZ (1) CZ291988B6 (fr)
FI (1) FI110307B (fr)
IL (1) IL104915A (fr)
MX (1) MX9301121A (fr)
NO (1) NO311327B1 (fr)
NZ (1) NZ268304A (fr)
PL (2) PL172790B1 (fr)
SK (1) SK285963B6 (fr)
WO (1) WO1993017686A1 (fr)
ZA (1) ZA931492B (fr)

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MX9301121A (es) 1992-03-02 1993-09-01 Schering Ag Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
US5468736A (en) * 1993-02-25 1995-11-21 The Medical College Of Hampton Road Hormone replacement therapy
DE4335876A1 (de) * 1993-10-17 1995-04-20 Schering Ag Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
DE19531936A1 (de) * 1995-08-17 1997-02-20 Schering Ag Kombinationspräparat zur Kontrazeption, Kits diese enthaltend und eine Methode diese verwendend
US5898032A (en) 1997-06-23 1999-04-27 Medical College Of Hampton Roads Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
KR20010032056A (ko) 1997-11-14 2001-04-16 에프.지.엠. 헤르만스 ; 이.에이치. 리링크 황체 호르몬-항 황체 호르몬 투약법
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
DE60014358D1 (de) * 1999-04-29 2004-11-04 Akzo Nobel Nv Verwendung von org 33245 in der kombinierten intermittierenden hormontherapie und empfängnisverhütung
CO5200773A1 (es) 1999-08-31 2002-09-27 Jenapharm Gmbh And Co Kg Mesoprogestinas (moduladores de receptores para progestero- na) como componente de composiciones utilizadas para la terapia de sustitucion hormonal (trh)
EP1453521B1 (fr) 2001-12-05 2013-09-04 Teva Women's Health, Inc. Contraceptifs oraux pour eviter les grossesses et diminuer la symptomatologie premenstruelle
US7772219B2 (en) 2003-05-02 2010-08-10 Teva Women's Health, Inc. Methods of hormonal treatment utilizing extended cycle contraceptive regimens
AU2004257772B2 (en) 2003-07-16 2009-12-17 Teva Women's Health, Inc. Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
TW200727920A (en) * 2005-06-21 2007-08-01 Organon Nv New regimens for oral monophasic contraceptives
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9603856B2 (en) * 2013-11-03 2017-03-28 Flamina Holding Ag Pharmaceutical composition or group of compositions for inhibiting autocrine HCG production in adult human cells
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
BR112016029338A2 (pt) 2014-07-29 2017-08-22 Therapeuticsmd Inc creme transdérmico
CA2966753A1 (fr) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Compositions a liberation prolongee d'onapristone et methodes associees
JP2018515552A (ja) * 2015-05-18 2018-06-14 アジル・セラピューティクス・インコーポレイテッドＡｇｉｌｅ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 避妊用組成物ならびに有効性改善および副作用調節方法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017053793A1 (fr) 2015-09-25 2017-03-30 Arno Therapeutics, Inc. Procédés de fabrication d'intermédiaires d'onapristone
US10548905B2 (en) 2015-12-15 2020-02-04 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
CA3020153A1 (fr) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Composition pharmaceutique d'hormone steroide
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

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US3890356A (en) 1973-03-26 1975-06-17 Richardson Merrell Inc 7-Alkyl-{66 {hu 3,5{b -steroids
US3928398A (en) 1973-11-01 1975-12-23 Richardson Merrell Inc Derivatives of 7{60 -methylestr-4-en-3{60 ,17{62 -diol
US4018919A (en) * 1975-07-16 1977-04-19 Eli Lilly And Company Sequential contraceptive method using two types of progestational agents
US4416822A (en) 1982-07-09 1983-11-22 The Upjohn Company 17β-Difluoromethyl steroids
IL68222A (en) 1983-03-24 1987-02-27 Yeda Res & Dev Contraceptive compositions comprising a progesterone antagonist and a blocker of progesterone activity
US4780461A (en) 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
ES8502612A1 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
IE61236B1 (en) * 1986-07-15 1994-10-19 American Home Prod Combination dosage form for pre-menopausal women
DE3702383A1 (de) 1987-01-23 1988-08-04 Schering Ag 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US5116818A (en) 1987-03-10 1992-05-26 Medical College Of Hampton Roads Method and kit for contraception with GnRH-antagonist
US5108995A (en) 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
MX9301121A (es) 1992-03-02 1993-09-01 Schering Ag Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
WO1993021926A1 (fr) 1992-05-06 1993-11-11 Medical College Of Hampton Roads Reduction des hemorragies uterines secondaires liees a la prise de progesterone
US5622943A (en) 1992-05-06 1997-04-22 The Medical College Of Hampton Roads Minimizing progestin associated breakthrough bleeding
US5516769A (en) 1993-02-19 1996-05-14 The Medical College Of Hampton Roads Method of inhibiting fertilization
US5468736A (en) 1993-02-25 1995-11-21 The Medical College Of Hampton Road Hormone replacement therapy
DE4344463A1 (de) 1993-12-22 1995-06-29 Schering Ag Kombinationsprodukt zur Kontrazeption

Also Published As

Publication number Publication date
PL172790B1 (pl) 1997-11-28
US7538099B1 (en) 2009-05-26
ZA931492B (en) 1993-12-23
AU3787993A (en) 1993-10-05
PL174785B1 (pl) 1998-09-30
EP0630246A1 (fr) 1994-12-28
JP4152431B2 (ja) 2008-09-17
CN1090481C (zh) 2002-09-11
AU678150B2 (en) 1997-05-22
JPH07509218A (ja) 1995-10-12
NZ268304A (en) 1997-02-24
IL104915A0 (en) 1993-07-08
EP0630246B1 (fr) 2008-07-16
IL104915A (en) 1998-07-15
EP0630246A4 (fr) 2002-07-17
SK104694A3 (en) 1996-01-10
CZ291988B6 (cs) 2003-07-16
NO943234D0 (no) 1994-09-01
MX9301121A (es) 1993-09-01
CZ211194A3 (en) 1995-12-13
FI110307B (fi) 2002-12-31
WO1993017686A1 (fr) 1993-09-16
NO311327B1 (no) 2001-11-19
NO943234L (no) 1994-11-01
BR9306005A (pt) 1998-06-23
CN1079386A (zh) 1993-12-15
FI944022A (fi) 1994-09-01
FI944022A0 (fi) 1994-09-01

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