SK283187B6 - Orálna kompozícia obsahujúca levosimendan - Google Patents

Orálna kompozícia obsahujúca levosimendan Download PDF

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Publication number
SK283187B6
SK283187B6 SK384-2000A SK3842000A SK283187B6 SK 283187 B6 SK283187 B6 SK 283187B6 SK 3842000 A SK3842000 A SK 3842000A SK 283187 B6 SK283187 B6 SK 283187B6
Authority
SK
Slovakia
Prior art keywords
levosimendan
active ingredient
composition
polymorphic form
compound
Prior art date
Application number
SK384-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK3842000A3 (en
Inventor
Maarit Harjula
Ilkka Larma
Saila Antila
Lasse Lehtonen
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of SK3842000A3 publication Critical patent/SK3842000A3/sk
Publication of SK283187B6 publication Critical patent/SK283187B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
SK384-2000A 1997-09-26 1998-09-24 Orálna kompozícia obsahujúca levosimendan SK283187B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973804A FI973804A (fi) 1997-09-26 1997-09-26 Levosimendaanin oraalisia koostumuksia
PCT/FI1998/000753 WO1999016443A1 (en) 1997-09-26 1998-09-24 Oral compositions of levosimendan

Publications (2)

Publication Number Publication Date
SK3842000A3 SK3842000A3 (en) 2000-09-12
SK283187B6 true SK283187B6 (sk) 2003-03-04

Family

ID=8549609

Family Applications (1)

Application Number Title Priority Date Filing Date
SK384-2000A SK283187B6 (sk) 1997-09-26 1998-09-24 Orálna kompozícia obsahujúca levosimendan

Country Status (36)

Country Link
US (1) US6355269B1 (fi)
EP (1) EP1014987B1 (fi)
JP (1) JP4493840B2 (fi)
KR (1) KR100762022B1 (fi)
CN (1) CN1149994C (fi)
AR (1) AR013519A1 (fi)
AT (1) ATE260659T1 (fi)
AU (1) AU732489B2 (fi)
BG (1) BG64746B1 (fi)
BR (1) BR9813213A (fi)
CA (1) CA2304702C (fi)
CZ (1) CZ294984B6 (fi)
DE (1) DE69822172T2 (fi)
DK (1) DK1014987T3 (fi)
EA (1) EA001647B1 (fi)
EE (1) EE03854B1 (fi)
ES (1) ES2217580T3 (fi)
FI (1) FI973804A (fi)
GE (1) GEP20032943B (fi)
HK (1) HK1032001A1 (fi)
HR (1) HRP20000171B1 (fi)
HU (1) HUP0003757A3 (fi)
ID (1) ID24486A (fi)
IL (1) IL134802A (fi)
MX (1) MXPA00002956A (fi)
MY (1) MY118156A (fi)
NO (1) NO320047B1 (fi)
NZ (1) NZ503207A (fi)
PL (1) PL190862B1 (fi)
PT (1) PT1014987E (fi)
RS (1) RS49708B (fi)
SI (1) SI1014987T1 (fi)
SK (1) SK283187B6 (fi)
TR (1) TR200000635T2 (fi)
WO (1) WO1999016443A1 (fi)
YU (1) YU17700A (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
DK1347747T3 (da) * 2000-12-22 2006-04-10 Baxter Int Fremgangsmåde til behandling af submikropartikelsuspensioner af farmaceutiske midler
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011465A0 (fi) * 2001-07-04 2001-07-04 Orion Corp Pyridatsinonijohdannaisen uusi käyttö
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
JP5747030B2 (ja) * 2009-07-14 2015-07-08 シプラ・リミテッド レボシメンダンの製造方法及びその方法で用いる中間体
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
EP4076398A4 (en) * 2019-12-16 2024-01-03 Tenax Therapeutics Inc LEVOSIMENDAN TO TREAT PULMONARY HYPERTENSION ACCOMPANIED BY HEART FAILURE BY MEANS OF PRESERVED EJECTION FRACTION (PH-HF-PEF)
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan

Also Published As

Publication number Publication date
NZ503207A (en) 2001-04-27
EE03854B1 (et) 2002-10-15
AU9350698A (en) 1999-04-23
EA200000360A1 (ru) 2000-10-30
NO20001585L (no) 2000-03-27
HRP20000171A2 (en) 2000-12-31
DE69822172D1 (de) 2004-04-08
EP1014987A1 (en) 2000-07-05
CN1271282A (zh) 2000-10-25
EE200000187A (et) 2001-04-16
NO320047B1 (no) 2005-10-17
SI1014987T1 (en) 2004-08-31
ATE260659T1 (de) 2004-03-15
CZ2000919A3 (cs) 2000-09-13
ID24486A (id) 2000-07-20
DE69822172T2 (de) 2005-02-24
GEP20032943B (en) 2003-04-25
BG104250A (en) 2000-12-29
US6355269B1 (en) 2002-03-12
KR100762022B1 (ko) 2007-09-28
NO20001585D0 (no) 2000-03-27
BG64746B1 (bg) 2006-02-28
AU732489B2 (en) 2001-04-26
MY118156A (en) 2004-09-30
SK3842000A3 (en) 2000-09-12
BR9813213A (pt) 2000-08-29
PL339461A1 (en) 2000-12-18
TR200000635T2 (tr) 2000-09-21
ES2217580T3 (es) 2004-11-01
KR20010030679A (ko) 2001-04-16
CA2304702A1 (en) 1999-04-08
IL134802A0 (en) 2001-04-30
AR013519A1 (es) 2000-12-27
EP1014987B1 (en) 2004-03-03
PT1014987E (pt) 2004-06-30
PL190862B1 (pl) 2006-02-28
JP4493840B2 (ja) 2010-06-30
WO1999016443A1 (en) 1999-04-08
CA2304702C (en) 2007-09-04
JP2001517702A (ja) 2001-10-09
MXPA00002956A (es) 2003-05-19
HUP0003757A3 (en) 2001-07-30
EA001647B1 (ru) 2001-06-25
YU17700A (sh) 2002-10-18
RS49708B (sr) 2007-12-31
CN1149994C (zh) 2004-05-19
IL134802A (en) 2004-01-04
FI973804A (fi) 1999-03-27
FI973804A0 (fi) 1997-09-26
HK1032001A1 (en) 2001-07-06
DK1014987T3 (da) 2004-05-24
HUP0003757A2 (hu) 2001-05-28
HRP20000171B1 (en) 2009-06-30
CZ294984B6 (cs) 2005-04-13

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Publication Publication Date Title
SK283187B6 (sk) Orálna kompozícia obsahujúca levosimendan
US5569657A (en) (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
EP2143715B1 (en) Method for obtaining pure enantiomers of a pyridazinone derivative

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110924