SK282945B6 - Perorálny prípravok na prevenciu a liečbu infekčných gastroenteritíd prasiat - Google Patents
Perorálny prípravok na prevenciu a liečbu infekčných gastroenteritíd prasiat Download PDFInfo
- Publication number
- SK282945B6 SK282945B6 SK237-99A SK23799A SK282945B6 SK 282945 B6 SK282945 B6 SK 282945B6 SK 23799 A SK23799 A SK 23799A SK 282945 B6 SK282945 B6 SK 282945B6
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- Prior art keywords
- capm
- strains
- porcine
- antibodies
- bacteria
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ1998859A CZ287989B6 (cs) | 1998-03-20 | 1998-03-20 | Perorální přípravek k prevenci a léčbě infekčních gastroenteritid prasat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK23799A3 SK23799A3 (en) | 1999-10-08 |
| SK282945B6 true SK282945B6 (sk) | 2003-01-09 |
Family
ID=5462362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK237-99A SK282945B6 (sk) | 1998-03-20 | 1999-02-24 | Perorálny prípravok na prevenciu a liečbu infekčných gastroenteritíd prasiat |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0955061A1 (cs) |
| CZ (1) | CZ287989B6 (cs) |
| PL (1) | PL191391B1 (cs) |
| SK (1) | SK282945B6 (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100437497B1 (ko) * | 2001-03-07 | 2004-06-25 | 주식회사 프로바이오닉 | 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제 |
| KR100542483B1 (ko) * | 2001-11-30 | 2006-01-16 | 주식회사 에그 바이오택 | 유아설사의 발병원인체인 대장균, 로타바이러스,아스트로바이러스에 대한 복합특수면역단백질을 함유한계란생산방법과 상기 계란에서 분리한복합특수면역단백질을 함유한 난황분말, 조제분유 |
| KR100471116B1 (ko) * | 2001-12-12 | 2005-03-08 | 주식회사 단바이오텍 | 장독성 대장균 감염의 예방 및 치료에 유용한 수용성단백질 및 이를 포함한 알 및 이들의 제조 방법 |
| EP1476184A4 (en) * | 2001-12-28 | 2006-01-04 | Camas Inc | IMMUNOGENOUS LIABILITY AND METHOD FOR ITS MANUFACTURE AND USE |
| KR100585391B1 (ko) * | 2002-01-24 | 2006-06-01 | 주식회사 프로바이오닉 | 돼지 전염성위장염 (TGE) 코로나바이러스 및 유해 미생물 억제 활성을 갖는 신규 락토바실러스 프란타럼 Probio-38 및 이를 함유하는 생균활성제 |
| KR100585392B1 (ko) * | 2002-01-24 | 2006-05-30 | 주식회사 프로바이오닉 | 돼지 전염성위장염 (TGE) 코로나바이러스 및 유해 미생물 억제 활성을 갖는 신규 락토바실러스 살리바리우스 Probio-37 및 이를 함유하는 생균활성제 |
| KR100492492B1 (ko) * | 2002-03-07 | 2005-05-31 | 주식회사 에그 바이오택 | 대장균(k88), 대장균(k99), 유행성설사병바이러스, 전염성위장염바이러스에 대한 복합특수면역단백질을 함유한 계란을 생산하는 방법 및 상기 방법으로 생산한 계란 |
| CA2404356A1 (en) * | 2002-09-18 | 2004-03-18 | Canadian Inovatech Inc. | Gram-positive antibacterial composition and method for use |
| CA2541753A1 (en) * | 2003-07-10 | 2005-01-20 | Michelle Alfa | Combination therapy for gastroenteric diseases caused by microorganisms |
| WO2005007834A1 (en) * | 2003-07-23 | 2005-01-27 | Probionic Corp. | Acid tolerant probiotic lactobacillus plantarum probio-38 that can suppress the growth of pathogenic microorganism and tge coronavirus |
| WO2005016383A1 (en) * | 2003-08-14 | 2005-02-24 | Merial Limited | Compositions and vaccines containing antigen(s) of cryptosporidium parvum and of another pathogen |
| JP2010531149A (ja) * | 2007-06-28 | 2010-09-24 | セーホーエル.ハンセン アクティーゼルスカブ | 細胞懸濁液の処理 |
| WO2011036539A1 (en) * | 2009-09-23 | 2011-03-31 | Borody Thomas J | Therapy for enteric infections |
| GB2484126A (en) | 2010-09-30 | 2012-04-04 | Univ Plymouth | Foodstuff fermented with lactic acid producing bacteria |
| DE102011006781A1 (de) * | 2011-04-05 | 2012-10-11 | Mat-Malta Advanced Technologies Limited | Antikörperprodukt, umfassend n spezifische Antikörper |
| DE102011006809A1 (de) | 2011-04-05 | 2012-10-11 | Freistaat Bayern vertreten durch die Julius-Maximilians-Universität Würzburg | Verwendung eines Mittels aus Antikörpern und/oder Insulin-like growth factor-Antagonisten |
| KR101353084B1 (ko) * | 2011-12-30 | 2014-01-17 | 대한민국 | 가금분변에서 분리한 항생제저항성 포도상구균과 살모넬라를 억제하는 신규유산균 락토바실러스 살리바리우스 |
| AR115757A1 (es) * | 2018-07-13 | 2021-02-24 | Cj Cheiljedang Corp | Composición que comprende la cepa cjlp475 de lactobacillus plantarum y la cepa cjlp17 de lactobacillus plantarum y el uso de la misma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0706400A1 (en) * | 1993-03-15 | 1996-04-17 | Pharma Pacific Pty. Ltd. | Therapeutic formulation and method |
| JPH10298105A (ja) * | 1997-04-23 | 1998-11-10 | Gen Corp:Kk | 腸管出血性大腸菌による感染症の予防剤および治療剤 |
| CZ287956B6 (cs) * | 1997-11-04 | 2001-03-14 | Medipharm Cz, S. R. O. | Perorální přípravek k prevenci a léčbě parvovirózy psů |
-
1998
- 1998-03-20 CZ CZ1998859A patent/CZ287989B6/cs not_active IP Right Cessation
-
1999
- 1999-02-16 EP EP99301120A patent/EP0955061A1/en not_active Ceased
- 1999-02-24 SK SK237-99A patent/SK282945B6/sk not_active IP Right Cessation
- 1999-03-20 PL PL332146A patent/PL191391B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK23799A3 (en) | 1999-10-08 |
| PL332146A1 (en) | 1999-09-27 |
| CZ85998A3 (cs) | 1998-10-14 |
| EP0955061A1 (en) | 1999-11-10 |
| PL191391B1 (pl) | 2006-05-31 |
| CZ287989B6 (cs) | 2001-03-14 |
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| Date | Code | Title | Description |
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
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