SK282665B6 - Cyklická aminokyselina a farmaceutický prostriedok na jej báze - Google Patents
Cyklická aminokyselina a farmaceutický prostriedok na jej báze Download PDFInfo
- Publication number
- SK282665B6 SK282665B6 SK1067-98A SK106798A SK282665B6 SK 282665 B6 SK282665 B6 SK 282665B6 SK 106798 A SK106798 A SK 106798A SK 282665 B6 SK282665 B6 SK 282665B6
- Authority
- SK
- Slovakia
- Prior art keywords
- amino acid
- cyclic amino
- group
- alkyl
- branched
- Prior art date
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- 239000005457 ice water Substances 0.000 description 1
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
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- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
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- 230000007510 mood change Effects 0.000 description 1
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- BNZBMEIFAOYZEA-UHFFFAOYSA-N n-cyanoacetamide Chemical compound CC(=O)NC#N BNZBMEIFAOYZEA-UHFFFAOYSA-N 0.000 description 1
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- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
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- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 208000027753 pain disease Diseases 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960005152 pentetrazol Drugs 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 208000033300 perinatal asphyxia Diseases 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 208000019899 phobic disease Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
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- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical group [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 description 1
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- 238000012353 t test Methods 0.000 description 1
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- 108060008037 tachykinin Proteins 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- OVRJVKCZJCNSOW-UHFFFAOYSA-N thian-4-one Chemical compound O=C1CCSCC1 OVRJVKCZJCNSOW-UHFFFAOYSA-N 0.000 description 1
- 239000012485 toluene extract Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- IIHPVYJPDKJYOU-UHFFFAOYSA-N triphenylcarbethoxymethylenephosphorane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC(=O)OCC)C1=CC=CC=C1 IIHPVYJPDKJYOU-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
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- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1127896P | 1996-02-07 | 1996-02-07 | |
| PCT/US1997/000255 WO1997029101A1 (en) | 1996-02-07 | 1997-01-02 | Novel cyclic amino acids as pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK106798A3 SK106798A3 (en) | 1999-07-12 |
| SK282665B6 true SK282665B6 (sk) | 2002-11-06 |
Family
ID=21749660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1067-98A SK282665B6 (sk) | 1996-02-07 | 1997-01-02 | Cyklická aminokyselina a farmaceutický prostriedok na jej báze |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5929088A (cs) |
| EP (1) | EP0888325B1 (cs) |
| JP (1) | JP2000511877A (cs) |
| KR (1) | KR19990082349A (cs) |
| AT (1) | ATE218135T1 (cs) |
| AU (1) | AU720628B2 (cs) |
| BR (1) | BR9707366A (cs) |
| CA (1) | CA2244708A1 (cs) |
| CZ (1) | CZ296052B6 (cs) |
| DE (1) | DE69712877T2 (cs) |
| DK (1) | DK0888325T3 (cs) |
| EA (1) | EA001534B1 (cs) |
| ES (1) | ES2176668T3 (cs) |
| HU (1) | HUP9901074A3 (cs) |
| IL (1) | IL125562A (cs) |
| NO (1) | NO983612L (cs) |
| NZ (1) | NZ326669A (cs) |
| PL (1) | PL328432A1 (cs) |
| PT (1) | PT888325E (cs) |
| SK (1) | SK282665B6 (cs) |
| WO (1) | WO1997029101A1 (cs) |
| ZA (1) | ZA97991B (cs) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU228426B1 (hu) | 1996-07-24 | 2013-03-28 | Warner Lambert Co | Izobutil-gaba és származékai alkalmazása fájdalom kezelésére alkalmas gyógyszer elõállítására |
| ES2197493T3 (es) * | 1997-09-18 | 2004-01-01 | Warner-Lambert Company Llc | Nuevos procedimientos estereoselectivos para la preparacion de analogos de gabapentina. |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| AU759392B2 (en) * | 1997-12-16 | 2003-04-10 | Warner-Lambert Company | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| EP1267896A1 (en) * | 2000-03-28 | 2003-01-02 | Robert J. Delorenzo | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| US6900192B2 (en) | 2000-10-06 | 2005-05-31 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| US6992076B2 (en) | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| MXPA03011566A (es) | 2001-06-11 | 2004-10-28 | Xenoport Inc | Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida. |
| JP2005501013A (ja) | 2001-06-11 | 2005-01-13 | ゼノポート，インコーポレイテッド | Ｇａｂａ類似体の全身濃度が持続するアミノ酸コンジュゲート |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US20040092498A1 (en) * | 2002-08-16 | 2004-05-13 | David Blakemore | Substituted glycine derivatives for use as medicaments |
| US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| JP2006511606A (ja) | 2002-12-13 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 下部尿路症状を治療するα−２−δリガンド |
| CA2537837A1 (en) | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Treating and/or preventing urinary incontinence using prodrugs of gaba analogs |
| JP2007505097A (ja) | 2003-09-12 | 2007-03-08 | ファイザー・インク | アルファ−２−デルタリガンドとセロトニン／ノルアドレナリン再取込み阻害薬を含む組合せ |
| KR101157436B1 (ko) | 2003-09-17 | 2012-07-05 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 하지불안 증후군의치료 또는 예방 |
| AU2004282192B2 (en) | 2003-10-14 | 2011-01-20 | Xenoport, Inc. | Crystalline form of gamma-aminobutyric acid analog |
| EP2343073A3 (en) | 2003-12-11 | 2011-10-12 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| AU2005301970B2 (en) | 2004-11-04 | 2011-06-02 | Arbor Pharmaceuticals, Llc | Gabapentin prodrug sustained release oral dosage forms |
| KR20090092307A (ko) | 2006-12-22 | 2009-08-31 | 레코르다티 아일랜드 리미티드 | 하요도 장애에 대한 α2δ 리간드 및 ＮＳＡＩＤｓ의 복합 치료 |
| EP2190833A1 (en) * | 2007-08-23 | 2010-06-02 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors |
| WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
| WO2009094577A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| WO2009094569A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates |
| US8268887B2 (en) | 2008-10-08 | 2012-09-18 | Feng Xu | Drug conjugates and methods of use thereof |
| WO2010084797A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 含ヘテロ原子化合物 |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
| WO2019219000A1 (en) | 2018-05-14 | 2019-11-21 | Xgene Pharmaceutical Inc. | Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| AU663330B2 (en) * | 1991-07-09 | 1995-10-05 | Nippon Soda Co., Ltd. | Heterocyclic cyclohexanedione derivative, production thereof, and herbicide |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| US5527194A (en) * | 1994-02-02 | 1996-06-18 | Brunswick Corporation | Thrust sensor for marine drives |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US5760006A (en) * | 1997-06-23 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating psoriasis |
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1997
- 1997-01-02 DE DE69712877T patent/DE69712877T2/de not_active Expired - Fee Related
- 1997-01-02 EA EA199800682A patent/EA001534B1/ru not_active IP Right Cessation
- 1997-01-02 AU AU15295/97A patent/AU720628B2/en not_active Ceased
- 1997-01-02 HU HU9901074A patent/HUP9901074A3/hu unknown
- 1997-01-02 IL IL12556297A patent/IL125562A/en not_active IP Right Cessation
- 1997-01-02 CA CA002244708A patent/CA2244708A1/en not_active Abandoned
- 1997-01-02 KR KR1019980706079A patent/KR19990082349A/ko not_active Ceased
- 1997-01-02 JP JP09528505A patent/JP2000511877A/ja not_active Abandoned
- 1997-01-02 PL PL97328432A patent/PL328432A1/xx unknown
- 1997-01-02 NZ NZ326669A patent/NZ326669A/en unknown
- 1997-01-02 AT AT97901385T patent/ATE218135T1/de not_active IP Right Cessation
- 1997-01-02 US US09/077,053 patent/US5929088A/en not_active Expired - Fee Related
- 1997-01-02 BR BR9707366A patent/BR9707366A/pt not_active Application Discontinuation
- 1997-01-02 CZ CZ19982452A patent/CZ296052B6/cs not_active IP Right Cessation
- 1997-01-02 EP EP97901385A patent/EP0888325B1/en not_active Expired - Lifetime
- 1997-01-02 DK DK97901385T patent/DK0888325T3/da active
- 1997-01-02 SK SK1067-98A patent/SK282665B6/sk unknown
- 1997-01-02 ES ES97901385T patent/ES2176668T3/es not_active Expired - Lifetime
- 1997-01-02 WO PCT/US1997/000255 patent/WO1997029101A1/en not_active Ceased
- 1997-01-02 PT PT97901385T patent/PT888325E/pt unknown
- 1997-02-06 ZA ZA9700991A patent/ZA97991B/xx unknown
-
1998
- 1998-08-06 NO NO983612A patent/NO983612L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888325B1 (en) | 2002-05-29 |
| PT888325E (pt) | 2002-10-31 |
| ES2176668T3 (es) | 2002-12-01 |
| ATE218135T1 (de) | 2002-06-15 |
| BR9707366A (pt) | 1999-07-20 |
| NO983612D0 (no) | 1998-08-06 |
| KR19990082349A (ko) | 1999-11-25 |
| CZ296052B6 (cs) | 2005-12-14 |
| AU1529597A (en) | 1997-08-28 |
| US5929088A (en) | 1999-07-27 |
| SK106798A3 (en) | 1999-07-12 |
| IL125562A (en) | 2001-08-08 |
| CZ245298A3 (cs) | 1998-11-11 |
| WO1997029101A1 (en) | 1997-08-14 |
| DE69712877T2 (de) | 2002-11-14 |
| CA2244708A1 (en) | 1997-08-14 |
| AU720628B2 (en) | 2000-06-08 |
| EA199800682A1 (ru) | 1999-02-25 |
| IL125562A0 (en) | 1999-03-12 |
| NZ326669A (en) | 2001-05-25 |
| ZA97991B (en) | 1997-08-15 |
| HUP9901074A2 (hu) | 2001-04-28 |
| EP0888325A1 (en) | 1999-01-07 |
| DK0888325T3 (da) | 2002-09-16 |
| DE69712877D1 (de) | 2002-07-04 |
| NO983612L (no) | 1998-10-06 |
| JP2000511877A (ja) | 2000-09-12 |
| PL328432A1 (en) | 1999-02-01 |
| HUP9901074A3 (en) | 2001-08-28 |
| EA001534B1 (ru) | 2001-04-23 |
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