SK282378B6 - Liečivo, ľavotočivý enantiomér derivátu dimetylbenzofuránu alebo dimetylbenzopyránu, spôsob a medziprodukty na jeho výrobu farmaceutický prostriedok - Google Patents

Liečivo, ľavotočivý enantiomér derivátu dimetylbenzofuránu alebo dimetylbenzopyránu, spôsob a medziprodukty na jeho výrobu farmaceutický prostriedok Download PDF

Info

Publication number
SK282378B6
SK282378B6 SK675-95A SK67595A SK282378B6 SK 282378 B6 SK282378 B6 SK 282378B6 SK 67595 A SK67595 A SK 67595A SK 282378 B6 SK282378 B6 SK 282378B6
Authority
SK
Slovakia
Prior art keywords
formula
methoxy
amino
group
cis
Prior art date
Application number
SK675-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK67595A3 (en
Inventor
Daele Georges Henri Paul Van
Jean-Paul Ren� Marie Andr� Bosmans
Laerhoven Willy Joannes Carolus Van
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK67595A3 publication Critical patent/SK67595A3/sk
Publication of SK282378B6 publication Critical patent/SK282378B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SK675-95A 1992-11-20 1993-11-15 Liečivo, ľavotočivý enantiomér derivátu dimetylbenzofuránu alebo dimetylbenzopyránu, spôsob a medziprodukty na jeho výrobu farmaceutický prostriedok SK282378B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97901392A 1992-11-20 1992-11-20
PCT/EP1993/003206 WO1994012494A1 (en) 1992-11-20 1993-11-15 Use of dimethylbenzofurans and dimethylbenzopyrans as 5-ht3 antagonists

Publications (2)

Publication Number Publication Date
SK67595A3 SK67595A3 (en) 1995-11-08
SK282378B6 true SK282378B6 (sk) 2002-01-07

Family

ID=25526607

Family Applications (1)

Application Number Title Priority Date Filing Date
SK675-95A SK282378B6 (sk) 1992-11-20 1993-11-15 Liečivo, ľavotočivý enantiomér derivátu dimetylbenzofuránu alebo dimetylbenzopyránu, spôsob a medziprodukty na jeho výrobu farmaceutický prostriedok

Country Status (31)

Country Link
US (2) US5674868A (enExample)
EP (1) EP0669919B1 (enExample)
JP (1) JP2830952B2 (enExample)
KR (1) KR0166661B1 (enExample)
AT (1) ATE176232T1 (enExample)
AU (1) AU680640B2 (enExample)
BG (1) BG62489B1 (enExample)
BR (1) BR9307477A (enExample)
CA (1) CA2149044C (enExample)
CZ (1) CZ287262B6 (enExample)
DE (1) DE69323322T2 (enExample)
DK (1) DK0669919T3 (enExample)
ES (1) ES2129615T3 (enExample)
FI (1) FI952458L (enExample)
GR (1) GR3029831T3 (enExample)
HU (2) HUT72740A (enExample)
IL (3) IL119273A0 (enExample)
LV (1) LV10956B (enExample)
MX (1) MX9307257A (enExample)
NO (2) NO307690B1 (enExample)
NZ (1) NZ257854A (enExample)
OA (1) OA10158A (enExample)
PL (1) PL176051B1 (enExample)
RO (1) RO115160B1 (enExample)
RU (1) RU2116072C1 (enExample)
SG (1) SG47488A1 (enExample)
SK (1) SK282378B6 (enExample)
TW (1) TW294595B (enExample)
UA (1) UA49792C2 (enExample)
WO (1) WO1994012494A1 (enExample)
ZA (1) ZA938676B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU745361B2 (en) 1997-04-18 2002-03-21 Janssen Pharmaceutica N.V. Use of 5HT3 antagonists for promoting intestinal lavage
HUP0003078A3 (en) * 1997-07-11 2002-02-28 Janssen Pharmaceutica Nv (+)-norcisapride useful for 5-ht3 and 5-ht4 mediated disorders
US6239122B1 (en) * 2000-01-05 2001-05-29 Joy Ann Steele Method of treatment of nausea, vomiting, and other disorders using estrogens
ATE440825T1 (de) * 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
NZ546990A (en) 2003-11-20 2010-03-26 Janssen Pharmaceutica Nv 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors
NZ546991A (en) 2003-11-20 2010-01-29 Janssen Pharmaceutica Nv 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors
CA2568835C (en) * 2004-06-30 2014-05-27 Janssen Pharmaceutica N.V. Quinazolinone derivatives as parp inhibitors
WO2006003147A1 (en) 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
JP5100376B2 (ja) 2004-06-30 2012-12-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
WO2009053373A1 (en) 2007-10-26 2009-04-30 Janssen Pharmaceutica Nv Quinolinone derivatives as parp inhibitors
WO2009118384A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
DK2271626T3 (en) 2008-03-27 2015-02-23 Janssen Pharmaceutica Nv TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
ZW12187A1 (en) * 1986-07-03 1989-02-01 Janssen Pharmaceutica Nv 4-(aroylamino)piperidinebutanamide derivatives
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US4914207A (en) * 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Also Published As

Publication number Publication date
SG47488A1 (en) 1998-04-17
PL176051B1 (pl) 1999-03-31
TW294595B (enExample) 1997-01-01
JP2830952B2 (ja) 1998-12-02
AU680640B2 (en) 1997-08-07
PL309045A1 (en) 1995-09-18
NZ257854A (en) 1997-04-24
IL107654A (en) 1998-01-04
DK0669919T3 (da) 1999-09-13
HU211546A9 (en) 1995-12-28
AU5465994A (en) 1994-06-22
BG62489B1 (bg) 1999-12-30
NO995762L (no) 1995-05-19
ZA938676B (en) 1995-05-19
GR3029831T3 (en) 1999-06-30
LV10956A (lv) 1995-12-20
FI952458A0 (fi) 1995-05-19
CZ287262B6 (en) 2000-10-11
UA49792C2 (uk) 2002-10-15
JPH08505840A (ja) 1996-06-25
BR9307477A (pt) 1999-06-29
FI952458A7 (fi) 1995-05-19
EP0669919B1 (en) 1999-01-27
FI952458L (fi) 1995-05-19
IL119273A (en) 2000-07-16
US5863923A (en) 1999-01-26
DE69323322D1 (de) 1999-03-11
ES2129615T3 (es) 1999-06-16
OA10158A (en) 1996-12-18
IL107654A0 (en) 1994-02-27
RU2116072C1 (ru) 1998-07-27
NO951980D0 (no) 1995-05-19
HUT72740A (en) 1996-05-28
KR0166661B1 (ko) 1999-01-15
IL119273A0 (en) 1996-12-05
MX9307257A (es) 1994-05-31
EP0669919A1 (en) 1995-09-06
DE69323322T2 (de) 1999-09-09
BG99593A (en) 1995-12-29
SK67595A3 (en) 1995-11-08
NO308530B1 (no) 2000-09-25
RU95113434A (ru) 1997-03-10
NO307690B1 (no) 2000-05-15
CA2149044A1 (en) 1994-06-09
WO1994012494A1 (en) 1994-06-09
CZ125895A3 (en) 1995-10-18
CA2149044C (en) 2007-04-03
HU9501476D0 (en) 1995-07-28
NO995762D0 (no) 1999-11-24
LV10956B (en) 1996-10-20
NO951980L (no) 1995-05-19
ATE176232T1 (de) 1999-02-15
RO115160B1 (ro) 1999-11-30
US5674868A (en) 1997-10-07

Similar Documents

Publication Publication Date Title
US5652246A (en) Piperidine compounds
US5077288A (en) 4-fluorobenzoic compounds with 5-HT2 - and α1 -antagonistic activities
US6395742B1 (en) 2,4-diaminopyrimidine derivatives
JPS6289679A (ja) ピペリジン誘導体
JPH01128968A (ja) 置換ｎ−（１−アルキル−３−ヒドロキシ−４−ピペリジニル）ベンズアミド類
KR0166661B1 (ko) 5-ht3 길항제로서 디메틸벤조푸란 및 디메틸벤조피란의 용도
NZ239267A (en) 3-substituted piperidine derivatives and pharmaceutical compositions
EP0589971A1 (en) Compounds
EP0411912A2 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
EP1448566B1 (en) Chemokine receptor antagonists and methods of use thereof
EP2266975A1 (en) 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds
JPS6130588A (ja) ベンゾ〔ｃ〕〔１，８〕ナフチリジン、その製造方法及びその使用、並びにこれらの化合物を含有する調製剤
EP1790646A1 (fr) Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
EP1421086B1 (en) 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
EP1409490B1 (en) 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta a|naphthalenyl derivatives with antipsychotic activity
EP0275962A2 (en) 3-Methylenespiro [benzofuran-piperidines], intermediates and a process for the preparation thereof, and their use as medicaments
JPH09291090A (ja) ピペリジノンおよびホモピペリジノン誘導体
HK1057864A1 (en) Piperazine derivatives, their preparation and their use for treating central nervous system (cns) disorders
HK1057864B (en) Piperazine derivatives, their preparation and their use for treating central nervous system (cns) disorders
HK1001396A1 (en) Pyrimidinylpyrazole derivative
HK1001396B (en) Pyrimidinylpyrazole derivative
HK1063789B (en) Chemokine receptor antagonists and methods of use thereof