SK281861B6 - Spôsob racemizácie opticky čistého substrátu 2-terc-butylkarboxamidpiperazínu alebo substrátu bohatého na 2-terc-butylkarboxamidpiperazín, alebo jeho solí a substrát na racemizáciu - Google Patents

Spôsob racemizácie opticky čistého substrátu 2-terc-butylkarboxamidpiperazínu alebo substrátu bohatého na 2-terc-butylkarboxamidpiperazín, alebo jeho solí a substrát na racemizáciu Download PDF

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Publication number
SK281861B6
SK281861B6 SK1006-96A SK100696A SK281861B6 SK 281861 B6 SK281861 B6 SK 281861B6 SK 100696 A SK100696 A SK 100696A SK 281861 B6 SK281861 B6 SK 281861B6
Authority
SK
Slovakia
Prior art keywords
tert
formula
substrate
salt
potassium
Prior art date
Application number
SK1006-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK100696A3 (en
Inventor
Kai Rossen
David Askin
Paul Reider
Richard J. Varsolona
Ralph P. Volante
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK100696A3 publication Critical patent/SK100696A3/sk
Publication of SK281861B6 publication Critical patent/SK281861B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
SK1006-96A 1994-02-04 1995-01-30 Spôsob racemizácie opticky čistého substrátu 2-terc-butylkarboxamidpiperazínu alebo substrátu bohatého na 2-terc-butylkarboxamidpiperazín, alebo jeho solí a substrát na racemizáciu SK281861B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19291694A 1994-02-04 1994-02-04
PCT/US1995/001232 WO1995021162A1 (en) 1994-02-04 1995-01-30 Process for making hiv protease inhibitors

Publications (2)

Publication Number Publication Date
SK100696A3 SK100696A3 (en) 1997-03-05
SK281861B6 true SK281861B6 (sk) 2001-08-06

Family

ID=22711555

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1006-96A SK281861B6 (sk) 1994-02-04 1995-01-30 Spôsob racemizácie opticky čistého substrátu 2-terc-butylkarboxamidpiperazínu alebo substrátu bohatého na 2-terc-butylkarboxamidpiperazín, alebo jeho solí a substrát na racemizáciu

Country Status (20)

Country Link
US (1) US5663341A (ja)
EP (1) EP0741712B1 (ja)
JP (1) JPH09508628A (ja)
KR (1) KR100337579B1 (ja)
AT (1) ATE206407T1 (ja)
AU (1) AU691878B2 (ja)
BR (1) BR9506727A (ja)
CA (1) CA2180947A1 (ja)
CZ (1) CZ291774B6 (ja)
DE (1) DE69523038T2 (ja)
ES (1) ES2161863T3 (ja)
FI (1) FI112218B (ja)
HU (1) HUT76303A (ja)
NZ (1) NZ279734A (ja)
RO (1) RO118292B1 (ja)
RU (1) RU2135482C1 (ja)
SK (1) SK281861B6 (ja)
TW (1) TW472047B (ja)
UA (1) UA46730C2 (ja)
WO (1) WO1995021162A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
DE69527683T2 (de) * 1994-04-22 2003-04-10 Koei Chemical Co., Ltd. Verfahren zur herstellung von optisch aktivem n-tert-butyl-2-piperazincarboxamidamid
ATE163642T1 (de) * 1994-11-04 1998-03-15 Yamakawa Chemical Ind Verfahren zur herstellung von optisch aktiven piperazinderivaten und zwischenprodukten für ihre herstellung
ATE226945T1 (de) * 1995-01-23 2002-11-15 Lonza Ag Verfahren zur herstellung von 1,4,5,6- tetrahydropyrazin-2-carbonsäureamiden
US5618937A (en) * 1995-03-15 1997-04-08 Merck & Co., Inc. Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide
US5612484A (en) * 1995-05-18 1997-03-18 Merck & Co., Inc. Process for making HIV protease inhibitors
DE19536658C2 (de) * 1995-09-30 1998-02-19 Degussa Verfahren zur kontinuierlichen Herstellung von basischen, cyclischen, optisch aktiven alpha-Aminosäuren
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US8404690B2 (en) 2003-02-14 2013-03-26 Merck Serono Sa Piperazine-2-carboxamide derivatives
GB0314260D0 (en) 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB604185A (en) * 1940-08-08 1948-06-30 Arthur Mandl Improvements in electric rectifier systems used in power or control systems such as for follow-up systems
US3692775A (en) * 1969-03-17 1972-09-19 Allied Chem Racemization of d-or l-{60 -amino-caprolactam in the presence of metal ions
US3852351A (en) * 1972-10-02 1974-12-03 Fmc Corp Chlorination of acetoacetamides
JPH01117869A (ja) * 1987-10-30 1989-05-10 Hokuriku Seiyaku Co Ltd ２−アミノメチルピペラジン誘導体
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.

Also Published As

Publication number Publication date
KR100337579B1 (ko) 2002-11-13
CA2180947A1 (en) 1995-08-10
CZ227296A3 (en) 1997-01-15
RO118292B1 (ro) 2003-04-30
DE69523038T2 (de) 2002-06-06
EP0741712B1 (en) 2001-10-04
BR9506727A (pt) 1997-09-23
UA46730C2 (uk) 2002-06-17
CZ291774B6 (cs) 2003-05-14
NZ279734A (en) 1998-05-27
FI963054A0 (fi) 1996-08-01
ATE206407T1 (de) 2001-10-15
AU691878B2 (en) 1998-05-28
AU1696795A (en) 1995-08-21
EP0741712A1 (en) 1996-11-13
JPH09508628A (ja) 1997-09-02
US5663341A (en) 1997-09-02
FI112218B (fi) 2003-11-14
HU9602143D0 (en) 1996-09-30
HUT76303A (en) 1997-07-28
DE69523038D1 (de) 2001-11-08
TW472047B (en) 2002-01-11
SK100696A3 (en) 1997-03-05
FI963054A (fi) 1996-08-01
RU2135482C1 (ru) 1999-08-27
MX9603218A (es) 1997-07-31
WO1995021162A1 (en) 1995-08-10
ES2161863T3 (es) 2001-12-16

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