MX9603218A - Procedimiento para hacer inhibidores de proteasa de virus de inmunodeficiencia humana y compuesto intermediario. - Google Patents
Procedimiento para hacer inhibidores de proteasa de virus de inmunodeficiencia humana y compuesto intermediario.Info
- Publication number
- MX9603218A MX9603218A MX9603218A MX9603218A MX9603218A MX 9603218 A MX9603218 A MX 9603218A MX 9603218 A MX9603218 A MX 9603218A MX 9603218 A MX9603218 A MX 9603218A MX 9603218 A MX9603218 A MX 9603218A
- Authority
- MX
- Mexico
- Prior art keywords
- hiv protease
- protease inhibitors
- piperazine
- optically pure
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Catalysts (AREA)
Abstract
Un procedimiento para la racemizacion de piperazin-2-ter-butilcarboxamidaopticamente pura o enriquecida y sus derivados, comprendiendo la reaccion del compuesto de piperazina opticamente puro o enriquecido con un agente de racemizacion seleccionado de una base fuerte, una sal de metal anhidra o un ácido carboxílico, en un solvente, en una escala de temperatura de entre la temperatura ambiente y 250 degree C; los derivados carboxamida de la piperazina son los intermediarios clave en la preparacion de los compuestos inhibidores de la proteasa de HIV; incluyendo el compuesto J.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19291694A | 1994-02-04 | 1994-02-04 | |
| US192916 | 1994-02-04 | ||
| PCT/US1995/001232 WO1995021162A1 (en) | 1994-02-04 | 1995-01-30 | Process for making hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9603218A true MX9603218A (es) | 1997-07-31 |
| MXPA96003218A MXPA96003218A (es) | 1997-12-01 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| RO118292B1 (ro) | 2003-04-30 |
| FI963054A0 (fi) | 1996-08-01 |
| CA2180947A1 (en) | 1995-08-10 |
| SK281861B6 (sk) | 2001-08-06 |
| DE69523038D1 (de) | 2001-11-08 |
| TW472047B (en) | 2002-01-11 |
| WO1995021162A1 (en) | 1995-08-10 |
| EP0741712B1 (en) | 2001-10-04 |
| AU691878B2 (en) | 1998-05-28 |
| ATE206407T1 (de) | 2001-10-15 |
| HUT76303A (en) | 1997-07-28 |
| JPH09508628A (ja) | 1997-09-02 |
| DE69523038T2 (de) | 2002-06-06 |
| KR100337579B1 (ko) | 2002-11-13 |
| BR9506727A (pt) | 1997-09-23 |
| FI963054A (fi) | 1996-08-01 |
| FI112218B (fi) | 2003-11-14 |
| HU9602143D0 (en) | 1996-09-30 |
| CZ291774B6 (cs) | 2003-05-14 |
| UA46730C2 (uk) | 2002-06-17 |
| US5663341A (en) | 1997-09-02 |
| ES2161863T3 (es) | 2001-12-16 |
| SK100696A3 (en) | 1997-03-05 |
| EP0741712A1 (en) | 1996-11-13 |
| AU1696795A (en) | 1995-08-21 |
| RU2135482C1 (ru) | 1999-08-27 |
| CZ227296A3 (en) | 1997-01-15 |
| NZ279734A (en) | 1998-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |