SK19512000A3 - 4-benzylpiperidínové alkylsulfoxidové heterocykly a ich použitie ako subtypovo selektívnych antagonistov nmda receptorov - Google Patents

4-benzylpiperidínové alkylsulfoxidové heterocykly a ich použitie ako subtypovo selektívnych antagonistov nmda receptorov Download PDF

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Publication number
SK19512000A3
SK19512000A3 SK1951-2000A SK19512000A SK19512000A3 SK 19512000 A3 SK19512000 A3 SK 19512000A3 SK 19512000 A SK19512000 A SK 19512000A SK 19512000 A3 SK19512000 A3 SK 19512000A3
Authority
SK
Slovakia
Prior art keywords
benzoxazol
piperidin
ethanesulfinyl
disease
fluorobenzyl
Prior art date
Application number
SK1951-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Jonathan L. Wright
Suzanne Ross Kesten
Ravindra B. Upsani
Nancy C. Lan
Original Assignee
Warner-Lambert Company
Cocensys, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company, Cocensys, Inc. filed Critical Warner-Lambert Company
Publication of SK19512000A3 publication Critical patent/SK19512000A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1951-2000A 1998-06-26 1999-06-25 4-benzylpiperidínové alkylsulfoxidové heterocykly a ich použitie ako subtypovo selektívnych antagonistov nmda receptorov SK19512000A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9091498P 1998-06-26 1998-06-26
PCT/US1999/014291 WO2000000197A1 (fr) 1998-06-26 1999-06-25 Heterocycles de 4-benzyl-piperidine alkylsulfoxyde et leur utilisation comme antagonistes selectifs de sous-type du recepteur du nmda

Publications (1)

Publication Number Publication Date
SK19512000A3 true SK19512000A3 (sk) 2001-08-06

Family

ID=22224939

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1951-2000A SK19512000A3 (sk) 1998-06-26 1999-06-25 4-benzylpiperidínové alkylsulfoxidové heterocykly a ich použitie ako subtypovo selektívnych antagonistov nmda receptorov

Country Status (28)

Country Link
US (1) US6284774B1 (fr)
EP (1) EP1089735B1 (fr)
JP (1) JP2002519322A (fr)
KR (1) KR20010053170A (fr)
CN (1) CN1304307A (fr)
AP (1) AP2000001949A0 (fr)
AT (1) ATE297207T1 (fr)
AU (1) AU769650B2 (fr)
BG (1) BG105082A (fr)
BR (1) BR9911575A (fr)
CA (1) CA2327888A1 (fr)
DE (1) DE69925730T2 (fr)
EA (1) EA200100058A1 (fr)
EE (1) EE200000778A (fr)
ES (1) ES2244201T3 (fr)
HU (1) HUP0102471A2 (fr)
ID (1) ID28005A (fr)
IL (1) IL138949A0 (fr)
IS (1) IS5667A (fr)
NO (1) NO20006482L (fr)
NZ (1) NZ508808A (fr)
OA (1) OA11570A (fr)
PE (1) PE20000728A1 (fr)
PL (1) PL345024A1 (fr)
SK (1) SK19512000A3 (fr)
TR (1) TR200003888T2 (fr)
WO (1) WO2000000197A1 (fr)
ZA (1) ZA200005848B (fr)

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US7217716B2 (en) 2001-02-23 2007-05-15 Merck & Co., Inc. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
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WO2002080928A1 (fr) 2001-04-03 2002-10-17 Merck & Co., Inc. Antagonistes de nmda/nr2b nonaryl-heterocyclo amidyle n-substitues
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Also Published As

Publication number Publication date
EP1089735A1 (fr) 2001-04-11
EP1089735A4 (fr) 2002-12-18
US6284774B1 (en) 2001-09-04
PL345024A1 (en) 2001-11-19
IS5667A (is) 2000-10-16
ES2244201T3 (es) 2005-12-01
AU4830399A (en) 2000-01-17
TR200003888T2 (tr) 2001-06-21
BG105082A (en) 2001-09-28
BR9911575A (pt) 2001-03-20
NO20006482D0 (no) 2000-12-19
NZ508808A (en) 2002-12-20
DE69925730T2 (de) 2006-03-23
KR20010053170A (ko) 2001-06-25
WO2000000197A1 (fr) 2000-01-06
ATE297207T1 (de) 2005-06-15
CN1304307A (zh) 2001-07-18
EE200000778A (et) 2002-04-15
EA200100058A1 (ru) 2001-08-27
JP2002519322A (ja) 2002-07-02
OA11570A (en) 2004-07-01
IL138949A0 (en) 2001-11-25
NO20006482L (no) 2000-12-19
CA2327888A1 (fr) 2000-01-06
DE69925730D1 (de) 2005-07-14
ID28005A (id) 2001-05-03
HUP0102471A2 (hu) 2002-05-29
ZA200005848B (en) 2001-12-18
EP1089735B1 (fr) 2005-06-08
AP2000001949A0 (en) 2000-12-31
AU769650B2 (en) 2004-01-29
PE20000728A1 (es) 2000-08-21

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