SK16612002A3 - Deriváty hygromycínu A na použitie na liečenie bakteriálnych a protozoálnych infekcií - Google Patents
Deriváty hygromycínu A na použitie na liečenie bakteriálnych a protozoálnych infekcií Download PDFInfo
- Publication number
- SK16612002A3 SK16612002A3 SK1661-2002A SK16612002A SK16612002A3 SK 16612002 A3 SK16612002 A3 SK 16612002A3 SK 16612002 A SK16612002 A SK 16612002A SK 16612002 A3 SK16612002 A3 SK 16612002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- group
- aryl
- dioxol
- yloxy
- Prior art date
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- 208000035143 Bacterial infection Diseases 0.000 title claims abstract description 19
- 208000022362 bacterial infectious disease Diseases 0.000 title claims abstract description 19
- 206010037075 Protozoal infections Diseases 0.000 title claims abstract description 18
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 12
- YQYJSBFKSSDGFO-FWAVGLHBSA-N hygromycin A Chemical class O[C@H]1[C@H](O)[C@H](C(=O)C)O[C@@H]1Oc1ccc(\C=C(/C)C(=O)N[C@@H]2[C@@H]([C@H]3OCO[C@H]3[C@@H](O)[C@@H]2O)O)cc1O YQYJSBFKSSDGFO-FWAVGLHBSA-N 0.000 title description 47
- 238000011282 treatment Methods 0.000 title description 8
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- 238000000034 method Methods 0.000 claims abstract description 49
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- 239000000651 prodrug Substances 0.000 claims abstract description 19
- 229940002612 prodrug Drugs 0.000 claims abstract description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
- 208000035475 disorder Diseases 0.000 claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 239000012453 solvate Substances 0.000 claims abstract description 5
- -1 heteroaromatic radicals Chemical class 0.000 claims description 131
- 239000000460 chlorine Substances 0.000 claims description 41
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 15
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
- 241000251468 Actinopterygii Species 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 6
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- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 6
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 2
- 150000005840 aryl radicals Chemical class 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 60
- 239000000243 solution Substances 0.000 description 51
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 34
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- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 14
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- 230000002829 reductive effect Effects 0.000 description 13
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- 238000002360 preparation method Methods 0.000 description 12
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000005308 thiazepinyl group Chemical group S1N=C(C=CC=C1)* 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 125000005503 thioxanyl group Chemical group 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20902300P | 2000-06-02 | 2000-06-02 | |
| PCT/IB2001/000946 WO2001092280A1 (en) | 2000-06-02 | 2001-05-25 | Hygromycin a derivatives for the treatment of bacterial and protozoal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK16612002A3 true SK16612002A3 (sk) | 2004-04-06 |
Family
ID=22777009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1661-2002A SK16612002A3 (sk) | 2000-06-02 | 2001-05-25 | Deriváty hygromycínu A na použitie na liečenie bakteriálnych a protozoálnych infekcií |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6867230B2 (es) |
| EP (1) | EP1287011A1 (es) |
| JP (1) | JP2003535100A (es) |
| KR (1) | KR20030010655A (es) |
| CN (1) | CN1432019A (es) |
| AP (1) | AP2002002669A0 (es) |
| AR (1) | AR028667A1 (es) |
| AU (1) | AU2001260528A1 (es) |
| BG (1) | BG107265A (es) |
| BR (1) | BR0111242A (es) |
| CA (1) | CA2410643A1 (es) |
| CZ (1) | CZ20023859A3 (es) |
| EA (1) | EA200201167A1 (es) |
| EC (1) | ECSP014093A (es) |
| EE (1) | EE200200671A (es) |
| GT (1) | GT200100099A (es) |
| HU (1) | HUP0302263A2 (es) |
| IL (1) | IL152984A0 (es) |
| IS (1) | IS6618A (es) |
| MA (1) | MA26909A1 (es) |
| MX (1) | MXPA02011966A (es) |
| NO (1) | NO20025704L (es) |
| OA (1) | OA12277A (es) |
| PA (1) | PA8518101A1 (es) |
| PE (1) | PE20020334A1 (es) |
| PL (1) | PL359179A1 (es) |
| SK (1) | SK16612002A3 (es) |
| SV (1) | SV2002000474A (es) |
| TN (1) | TNSN01080A1 (es) |
| UY (1) | UY26741A1 (es) |
| WO (1) | WO2001092280A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ570989A (en) | 2002-05-16 | 2010-01-29 | Sepracor Inc | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof |
| US20210275559A1 (en) * | 2018-08-20 | 2021-09-09 | Kim Lewis | Hygromycin a compounds and methods of treating spirochete diseases |
| CU20180159A7 (es) * | 2018-12-28 | 2020-10-20 | Chengdu Olisynn Biotechnology Co Ltd | Derivados de oligosacáridos sintéticos como vacuna contra la bordetella pertussis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1234567A (en) * | 1915-09-14 | 1917-07-24 | Edward J Quigley | Soft collar. |
| US2004123A (en) * | 1934-02-15 | 1935-06-11 | Jr Robert B Loibl | Pest exterminator |
| AU755806B2 (en) * | 1998-05-04 | 2002-12-19 | Pfizer Products Inc. | Hygromycin A derivatives |
| WO1999057127A1 (en) * | 1998-05-04 | 1999-11-11 | Pfizer Products Inc. | 2'-deoxy hygromycin derivatives |
| KR100418167B1 (ko) * | 1998-12-02 | 2004-02-11 | 화이자 프로덕츠 인크. | 항균제로서의 하이그로마이신 ａ 유도체 |
| IL148577A0 (en) * | 1999-10-29 | 2002-09-12 | Pfizer Prod Inc | Hygromycin derivatives |
| US7654321B2 (en) * | 2006-12-27 | 2010-02-02 | Schlumberger Technology Corporation | Formation fluid sampling apparatus and methods |
-
2001
- 2001-05-25 EE EEP200200671A patent/EE200200671A/xx unknown
- 2001-05-25 BR BR0111242-2A patent/BR0111242A/pt not_active IP Right Cessation
- 2001-05-25 IL IL15298401A patent/IL152984A0/xx unknown
- 2001-05-25 OA OA1200200361A patent/OA12277A/en unknown
- 2001-05-25 WO PCT/IB2001/000946 patent/WO2001092280A1/en not_active Application Discontinuation
- 2001-05-25 PL PL01359179A patent/PL359179A1/xx not_active Application Discontinuation
- 2001-05-25 AU AU2001260528A patent/AU2001260528A1/en not_active Abandoned
- 2001-05-25 CZ CZ20023859A patent/CZ20023859A3/cs unknown
- 2001-05-25 SK SK1661-2002A patent/SK16612002A3/sk unknown
- 2001-05-25 MX MXPA02011966A patent/MXPA02011966A/es not_active Application Discontinuation
- 2001-05-25 EA EA200201167A patent/EA200201167A1/ru unknown
- 2001-05-25 KR KR1020027016396A patent/KR20030010655A/ko not_active Application Discontinuation
- 2001-05-25 EP EP01934231A patent/EP1287011A1/en not_active Withdrawn
- 2001-05-25 CA CA002410643A patent/CA2410643A1/en not_active Abandoned
- 2001-05-25 AP APAP/P/2002/002669A patent/AP2002002669A0/en unknown
- 2001-05-25 CN CN01810623A patent/CN1432019A/zh active Pending
- 2001-05-25 HU HU0302263A patent/HUP0302263A2/hu unknown
- 2001-05-25 JP JP2002500893A patent/JP2003535100A/ja not_active Withdrawn
- 2001-05-30 PA PA20018518101A patent/PA8518101A1/es unknown
- 2001-05-30 GT GT200100099A patent/GT200100099A/es unknown
- 2001-05-31 UY UY26741A patent/UY26741A1/es not_active Application Discontinuation
- 2001-06-01 SV SV2001000474A patent/SV2002000474A/es not_active Application Discontinuation
- 2001-06-01 US US09/872,731 patent/US6867230B2/en not_active Expired - Fee Related
- 2001-06-01 EC EC2001004093A patent/ECSP014093A/es unknown
- 2001-06-01 AR ARP010102642A patent/AR028667A1/es unknown
- 2001-06-01 TN TNTNSN01080A patent/TNSN01080A1/fr unknown
- 2001-06-01 PE PE2001000511A patent/PE20020334A1/es not_active Application Discontinuation
-
2002
- 2002-11-12 BG BG107265A patent/BG107265A/bg unknown
- 2002-11-14 IS IS6618A patent/IS6618A/is unknown
- 2002-11-27 NO NO20025704A patent/NO20025704L/no not_active Application Discontinuation
- 2002-11-29 MA MA26928A patent/MA26909A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1432019A (zh) | 2003-07-23 |
| US20030045528A1 (en) | 2003-03-06 |
| EE200200671A (et) | 2004-08-16 |
| IL152984A0 (en) | 2003-06-24 |
| ECSP014093A (es) | 2002-01-25 |
| US6867230B2 (en) | 2005-03-15 |
| NO20025704D0 (no) | 2002-11-27 |
| UY26741A1 (es) | 2001-12-28 |
| OA12277A (en) | 2006-05-11 |
| KR20030010655A (ko) | 2003-02-05 |
| EA200201167A1 (ru) | 2003-06-26 |
| GT200100099A (es) | 2002-01-31 |
| WO2001092280A1 (en) | 2001-12-06 |
| EP1287011A1 (en) | 2003-03-05 |
| MXPA02011966A (es) | 2003-04-22 |
| AR028667A1 (es) | 2003-05-21 |
| TNSN01080A1 (fr) | 2005-11-10 |
| CZ20023859A3 (cs) | 2004-02-18 |
| AU2001260528A1 (en) | 2001-12-11 |
| IS6618A (is) | 2002-11-14 |
| SV2002000474A (es) | 2002-07-03 |
| NO20025704L (no) | 2002-11-27 |
| BR0111242A (pt) | 2003-06-03 |
| MA26909A1 (fr) | 2004-12-20 |
| PA8518101A1 (es) | 2002-09-17 |
| PE20020334A1 (es) | 2002-04-30 |
| CA2410643A1 (en) | 2001-12-06 |
| HUP0302263A2 (hu) | 2003-10-28 |
| PL359179A1 (en) | 2004-08-23 |
| BG107265A (bg) | 2003-07-31 |
| JP2003535100A (ja) | 2003-11-25 |
| AP2002002669A0 (en) | 2002-12-31 |
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